Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Letters in Drug Design & Discovery
  4. Volume 21, Issue 16
  5. Article
Volume 21, Issue 16
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

Migraine is an unusual piercing headache on one side of the head. It is due to the dysregulation of epigenetic factors associated with the brain. Migraine affects about one percent of the general population. Despite the recent implementation of worldwide diagnostic criteria for migraine, this disorder remains relatively unknown and is frequently underdiagnosed. Migrainous conditions are also associated with anxiety and stress. This pathologic condition affects the daily life and productivity of the patients.

Objective

Hence, there is a need to develop proper treatment and management strategies to cope with migraine and associated anxiety. Through approaches, this work elucidates to identify the effective lead compounds for migraine and anxiety.

Methods

Brain-derived neurotrophic factor (BDNF) was identified as a possible target for treating migraine and anxiety using computational analysis. Virtual screening and molecular dynamics simulation were used to find potential agonists with high affinities for BDNF.

Results

Based on the results of computational analysis (glide XP score, number of interactions, glide energy, and pharmacokinetic factors), four top hit molecules (Asinex_35922, Enamine_44630, Maybridge_1999, and SMMDB_17457) were identified and taken for further analysis. The hydrogen bond interactions between the agonists and the BDNF protein were verified by dynamics analysis.

Conclusion

Computational studies support that BDNF agonist molecules could be effective regulating molecules for migraine and anxiety. For further evidence of the effectiveness of lead compounds in treating migraine and related anxiety, more experimental studies are necessary.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/lddd/10.2174/0115701808274096231207042744
2024-02-02
2024-12-23

  • From This Site

    /content/journals/lddd/10.2174/0115701808274096231207042744
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. GoadsbyP.J. LiptonR.B. FerrariM.D. Migraine--current understanding and treatment.N. Engl. J. Med.2002346425727010.1056/NEJMra01091711807151
     [Google Scholar]
  2. VosT. BarberR.M. BellB. Bertozzi-VillaA. BiryukovS. BolligerI. CharlsonF. DavisA. DegenhardtL. DickerD. DuanL. ErskineH. FeiginV.L. FerrariA.J. FitzmauriceC. FlemingT. GraetzN. GuinovartC. HaagsmaJ. HansenG.M. HansonS.W. HeutonK.R. HigashiH. KassebaumN. KyuH. LaurieE. LiangX. LofgrenK. LozanoR. MacIntyreM.F. Moradi-LakehM. NaghaviM. NguyenG. OdellS. OrtbladK. RobertsD.A. RothG.A. SandarL. SerinaP.T. StanawayJ.D. SteinerC. ThomasB. VollsetS.E. WhitefordH. WolockT.M. YeP. ZhouM. ÃvilaM.A. AasvangG.M. AbbafatiC. OzgorenA.A. Abd-AllahF. AzizM.I.A. AberaS.F. AboyansV. AbrahamJ.P. AbrahamB. AbubakarI. Abu-RaddadL.J. Abu-RmeilehN.M.E. AburtoT.C. AchokiT. AckermanI.N. AdelekanA. AdemiZ. AdouA.K. AdsuarJ.C. ArnlovJ. AgardhE.E. Al KhabouriM.J. AlamS.S. AlasfoorD. AlbittarM.I. AlegrettiM.A. AlemanA.V. AlemuZ.A. Alfonso-CristanchoR. AlhabibS. AliR. AllaF. AllebeckP. AllenP.J. AlMazroaM.A.A. AlsharifU. AlvarezE. Alvis-GuzmanN. AmeliO. AminiH. AmmarW. AndersonB.O. AndersonH.R. AntonioC.A.T. AnwariP. ApfelH. ArsenijevicV.S.A. ArtamanA. AsgharR.J. AssadiR. AtkinsL.S. AtkinsonC. BadawiA. BahitM.C. BakfalouniT. BalakrishnanK. BalallaS. BanerjeeA. Barker-ColloS.L. BarqueraS. BarregardL. BarreroL.H. BasuS. BasuA. BaxterA. BeardsleyJ. BediN. BeghiE. BekeleT. BellM.L. BenjetC. BennettD.A. BensenorI.M. BenzianH. BernabeE. BeyeneT.J. BhalaN. BhallaA. BhuttaZ. BienhoffK. BikbovB. AbdulhakA.B. BloreJ.D. BlythF.M. BohenskyM.A. BasaraB.B. BorgesG. BornsteinN.M. BoseD. BoufousS. BourneR.R. BoyersL.N. BraininM. BrauerM. BrayneC.E.G. BrazinovaA. BreitbordeN.J.K. BrennerH. BriggsA.D.M. BrooksP.M. BrownJ. BrughaT.S. BuchbinderR. BuckleG.C. BukhmanG. BullochA.G. BurchM. BurnettR. CardenasR. CabralN.L. NonatoI.R.C. CampuzanoJ.C. CarapetisJ.R. CarpenterD.O. CasoV. Castaneda-OrjuelaC.A. Catala-LopezF. ChadhaV.K. ChangJ-C. ChenH. ChenW. ChiangP.P. Chimed-OchirO. ChowdhuryR. ChristensenH. ChristophiC.A. ChughS.S. CirilloM. CoggeshallM. CohenA. ColistroV. ColquhounS.M. ContrerasA.G. CooperL.T. CooperC. CooperriderK. CoreshJ. CortinovisM. CriquiM.H. CrumpJ.A. Cuevas-NasuL. DandonaR. DandonaL. DansereauE. DantesH.G. DarganP.I. DaveyG. DavitoiuD.V. DayamaA. De la Cruz-GongoraV. de la VegaS.F. De LeoD. del Pozo-CruzB. DellavalleR.P. DeribeK. DerrettS. Des JarlaisD.C. DessalegnM. deVeberG.A. DharmaratneS.D. Diaz-TorneC. DingE.L. DokovaK. DorseyE.R. DriscollT.R. DuberH. DurraniA.M. EdmondK.M. EllenbogenR.G. EndresM. ErmakovS.P. EshratiB. EsteghamatiA. EstepK. FahimiS. FarzadfarF. FayD.F.J. FelsonD.T. FereshtehnejadS-M. FernandesJ.G. FerriC.P. FlaxmanA. FoigtN. ForemanK.J. FowkesF.G.R. FranklinR.C. FurstT. FutranN.D. GabbeB.J. GankpeF.G. Garcia-GuerraF.A. GeleijnseJ.M. GessnerB.D. GibneyK.B. GillumR.F. GinawiI.A. GiroudM. GiussaniG. GoenkaS. GoginashviliK. GonaP. de CosioT.G. GosselinR.A. GotayC.C. GotoA. GoudaH.N. GuerrantR. GugnaniH.C. GunnellD. GuptaR. GuptaR. GutierrezR.A. Hafezi-NejadN. HaganH. HalasaY. HamadehR.R. HamavidH. HammamiM. HankeyG.J. HaoY. HarbH.L. HaroJ.M. HavmoellerR. HayR.J. HayS. HedayatiM.T. PiI.B.H. HeydarpourP. HijarM. HoekH.W. HoffmanH.J. HornbergerJ.C. HosgoodH.D. HossainM. HotezP.J. HoyD.G. HsairiM. HuH. HuG. HuangJ.J. HuangC. HuiartL. HusseiniA. IannaroneM. IburgK.M. InnosK. InoueM. JacobsenK.H. JassalS.K. JeemonP. JensenP.N. JhaV. JiangG. JiangY. JonasJ.B. JosephJ. JuelK. KanH. KarchA. KarimkhaniC. KarthikeyanG. KatzR. KaulA. KawakamiN. KaziD.S. KempA.H. KengneA.P. KhaderY.S. KhalifaS.E.A.H. KhanE.A. KhanG. KhangY-H. KhonelidzeI. KielingC. KimD. KimS. KimokotiR.W. KinfuY. KingeJ.M. KisselaB.M. KivipeltoM. KnibbsL. KnudsenA.K. KokuboY. KosenS. KramerA. KravchenkoM. KrishnamurthiR.V. KrishnaswamiS. DefoB.K. BicerB.K. KuipersE.J. KulkarniV.S. KumarK. KumarG.A. KwanG.F. LaiT. LallooR. LamH. LanQ. LansinghV.C. LarsonH. LarssonA. LawrynowiczA.E.B. LeasherJ.L. LeeJ-T. LeighJ. LeungR. LeviM. LiB. LiY. LiY. liang, J.; Lim, S.; Lin, H-H.; Lind, M.; Lindsay, M.P.; Lipshultz, S.E.; Liu, S.; Lloyd, B.K.; Ohno, S.L.; Logroscino, G.; Looker, K.J.; Lopez, A.D.; Lopez-Olmedo, N.; Lortet-Tieulent, J.; Lotufo, P.A.; Low, N.; Lucas, R.M.; Lunevicius, R.; Lyons, R.A.; Ma, J.; Ma, S.; Mackay, M.T.; Majdan, M.; Malekzadeh, R.; Mapoma, C.C.; Marcenes, W.; March, L.M.; Margono, C.; Marks, G.B.; Marzan, M.B.; Masci, J.R.; Mason-Jones, A.J.; Matzopoulos, R.G.; Mayosi, B.M.; Mazorodze, T.T.; McGill, N.W.; McGrath, J.J.; McKee, M.; McLain, A.; McMahon, B.J.; Meaney, P.A.; Mehndiratta, M.M.; Mejia-Rodriguez, F.; Mekonnen, W.; Melaku, Y.A.; Meltzer, M.; Memish, Z.A.; Mensah, G.; Meretoja, A.; Mhimbira, F.A.; Micha, R.; Miller, T.R.; Mills, E.J.; Mitchell, P.B.; Mock, C.N.; Moffitt, T.E.; Ibrahim, N.M.; Mohammad, K.A.; Mokdad, A.H.; Mola, G.L.; Monasta, L.; Montico, M.; Montine, T.J.; Moore, A.R.; Moran, A.E.; Morawska, L.; Mori, R.; Moschandreas, J.; Moturi, W.N.; Moyer, M.; Mozaffarian, D.; Mueller, U.O.; Mukaigawara, M.; Murdoch, M.E.; Murray, J.; Murthy, K.S.; Naghavi, P.; Nahas, Z.; Naheed, A.; Naidoo, K.S.; Naldi, L.; Nand, D.; Nangia, V.; Narayan, K.M.V.; Nash, D.; Nejjari, C.; Neupane, S.P.; Newman, L.M.; Newton, C.R.; Ng, M.; Ngalesoni, F.N.; Nhung, N.T.; Nisar, M.I.; Nolte, S.; Norheim, O.F.; Norman, R.E.; Norrving, B.; Nyakarahuka, L.; Oh, I.H.; Ohkubo, T.; Omer, S.B.; Opio, J.N.; Ortiz, A.; Pandian, J.D.; Panelo, C.I.A.; Papachristou, C.; Park, E-K.; Parry, C.D.; Caicedo, A.J.P.; Patten, S.B.; Paul, V.K.; Pavlin, B.I.; Pearce, N.; Pedraza, L.S.; Pellegrini, C.A.; Pereira, D.M.; Perez-Ruiz, F.P.; Perico, N.; Pervaiz, A.; Pesudovs, K.; Peterson, C.B.; Petzold, M.; Phillips, M.R.; Phillips, D.; Phillips, B.; Piel, F.B.; Plass, D.; Poenaru, D.; Polanczyk, G.V.; Polinder, S.; Pope, C.A.; Popova, S.; Poulton, R.G.; Pourmalek, F.; Prabhakaran, D.; Prasad, N.M.; Qato, D.; Quistberg, D.A.; Rafay, A.; Rahimi, K.; Rahimi-Movaghar, V.; Rahman, S.; Raju, M.; Rakovac, I.; Rana, S.M.; Razavi, H.; Refaat, A.; Rehm, J.; Remuzzi, G.; Resnikoff, S.; Ribeiro, A.L.; Riccio, P.M.; Richardson, L.; Richardus, J.H.; Riederer, A.M.; Robinson, M.; Roca, A.; Rodriguez, A.; Rojas-Rueda, D.; Ronfani, L.; Rothenbacher, D.; Roy, N.; Ruhago, G.M.; Sabin, N.; Sacco, R.L.; Ksoreide, K.; Saha, S.; Sahathevan, R.; Sahraian, M.A.; Sampson, U.; Sanabria, J.R.; Sanchez-Riera, L.; Santos, I.S.; Satpathy, M.; Saunders, J.E.; Sawhney, M.; Saylan, M.I.; Scarborough, P.; Schoettker, B.; Schneider, I.J.C.; Schwebel, D.C.; Scott, J.G.; Seedat, S.; Sepanlou, S.G.; Serdar, B.; Servan-Mori, E.E.; Shackelford, K.; Shaheen, A.; Shahraz, S.; Levy, T.S.; Shangguan, S.; She, J.; Sheikhbahaei, S.; Shepard, D.S.; Shi, P.; Shibuya, K.; Shinohara, Y.; Shiri, R.; Shishani, K.; Shiue, I.; Shrime, M.G.; Sigfusdottir, I.D.; Silberberg, D.H.; Simard, E.P.; Sindi, S.; Singh, J.A.; Singh, L.; Skirbekk, V.; Sliwa, K.; Soljak, M.; Soneji, S.; Soshnikov, S.S.; Speyer, P.; Sposato, L.A.; Sreeramareddy, C.T.; Stoeckl, H.; Stathopoulou, V.K.; Steckling, N.; Stein, M.B.; Stein, D.J.; Steiner, T.J.; Stewart, A.; Stork, E.; Stovner, L.J.; Stroumpoulis, K.; Sturua, L.; Sunguya, B.F.; Swaroop, M.; Sykes, B.L.; Tabb, K.M.; Takahashi, K.; Tan, F.; Tandon, N.; Tanne, D.; Tanner, M.; Tavakkoli, M.; Taylor, H.R.; Te Ao, B.J.; Temesgen, A.M.; Have, M.T.; Tenkorang, E.Y.; Terkawi, A.S.; Theadom, A.M.; Thomas, E.; Thorne-Lyman, A.L.; Thrift, A.G.; Tleyjeh, I.M.; Tonelli, M.; Topouzis, F.; Towbin, J.A.; Toyoshima, H.; Traebert, J.; Tran, B.X.; Trasande, L.; Trillini, M.; Truelsen, T.; Trujillo, U.; Tsilimbaris, M.; Tuzcu, E.M.; Ukwaja, K.N.; Undurraga, E.A.; Uzun, S.B.; van Brakel, W.H.; van de Vijver, S.; Dingenen, R.V.; van Gool, C.H.; Varakin, Y.Y.; Vasankari, T.J.; Vavilala, M.S.; Veerman, L.J.; Velasquez-Melendez, G.; Venketasubramanian, N.; Vijayakumar, L.; Villalpando, S.; Violante, F.S.; Vlassov, V.V.; Waller, S.; Wallin, M.T.; Wan, X.; Wang, L.; Wang, J.L.; Wang, Y.; Warouw, T.S.; Weichenthal, S.; Weiderpass, E.; Weintraub, R.G.; Werdecker, A.; Wessells, K.R.R.; Westerman, R.; Wilkinson, J.D.; Williams, H.C.; Williams, T.N.; Woldeyohannes, S.M.; Wolfe, C.D.A.; Wong, J.Q.; Wong, H.; Woolf, A.D.; Wright, J.L.; Wurtz, B.; Xu, G.; Yang, G.; Yano, Y.; Yenesew, M.A.; Yentur, G.K.; Yip, P.; Yonemoto, N.; Yoon, S-J.; Younis, M.; Yu, C.; Kim, K.Y.; Zaki, M.E.S.; Zhang, Y.; Zhao, Z.; Zhao, Y.; Zhu, J.; Zonies, D.; Zunt, J.R.; Salomon, J.A.; Murray, C.J.L. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013.Lancet2015386999574380010.1016/S0140‑6736(15)60692‑426063472
     [Google Scholar]
  3. BuseD.C. ManackA. SerranoD. TurkelC. LiptonR.B. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers.J. Neurol. Neurosurg. Psychiatry201081442843210.1136/jnnp.2009.19249220164501
     [Google Scholar]
  4. AmiriP. KazeminasabS. NejadghaderiS.A. MohammadinasabR. PourfathiH. Araj-KhodaeiM. SullmanM.J.M. KolahiA-A. SafiriS. Migraine: A review on its history, global epidemiology, risk factors, and comorbidities.Front. Neurol.20221280060510.3389/fneur.2021.800605
     [Google Scholar]
  5. GiffinN.J. RuggieroL. LiptonR.B. SilbersteinS.D. TvedskovJ.F. OlesenJ. AltmanJ. GoadsbyP.J. MacraeA. Premonitory symptoms in migraine: An electronic diary study.Neurology200360693594010.1212/01.WNL.0000052998.58526.A912654956
     [Google Scholar]
  6. GiffinN.J. LiptonR.B. SilbersteinS.D. OlesenJ. GoadsbyP.J. The migraine postdrome.Neurology201687330931310.1212/WNL.000000000000278927335112
     [Google Scholar]
  7. KelmanL. The postdrome of the acute migraine attack.Cephalalgia200626221422010.1111/j.1468‑2982.2005.01026.x16426278
     [Google Scholar]
  8. RasmussenB.K. OlesenJ. Migraine with aura and migraine without aura: An epidemiological study.Cephalalgia199212422122810.1046/j.1468‑2982.1992.1204221.x1525797
     [Google Scholar]
  9. MarkowitzS. SaitoK. MoskowitzM.A. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain.J. Neurosci.19877124129413610.1523/JNEUROSCI.07‑12‑04129.19873694267
     [Google Scholar]
  10. RadatF. SwendsenJ. Psychiatric comorbidity in migraine: A review.Cephalalgia200525316517810.1111/j.1468‑2982.2004.00839.x15689191
     [Google Scholar]
  11. AntonaciF. NappiG. GalliF. ManzoniG.C. CalabresiP. CostaA. Migraine and psychiatric comorbidity: A review of clinical findings.J. Headache Pain201112211512510.1007/s10194‑010‑0282‑421210177
     [Google Scholar]
  12. DreslerT. CaratozzoloS. GuldolfK. HuhnJ.I. LoiaconoC. Niiberg-PikksöötT. PumaM. SforzaG. TobiaA. OrnelloR. SerafiniG. Understanding the nature of psychiatric comorbidity in migraine: A systematic review focused on interactions and treatment implications.J. Headache Pain20192015110.1186/s10194‑019‑0988‑x31072313
     [Google Scholar]
  13. LamplC. ThomasH. TassorelliC. KatsaravaZ. LaínezJ.M. Lantéri-MinetM. RastenyteD. de la TorreR.E. StovnerL.J. AndréeC. SteinerT.J. Headache, depression and anxiety: Associations in the Eurolight project.J. Headache Pain20161715910.1186/s10194‑016‑0649‑227245683
     [Google Scholar]
  14. KarimiL. CrewtherS.G. WijeratneT. EvansA.E. AfshariL. KhalilH. The prevalence of migraine with anxiety among genders.Front. Neurol.202011125210.3389/fneur.2020.569405
     [Google Scholar]
  15. BlumenfeldA.M. VaronS.F. WilcoxT.K. BuseD.C. KawataA.K. ManackA. GoadsbyP.J. LiptonR.B. Disability, HRQoL and resource use among chronic and episodic migraineurs: Results from the International Burden of Migraine Study (IBMS).Cephalalgia201131330131510.1177/033310241038114520813784
     [Google Scholar]
  16. ZwartJ.A. DybG. HagenK. ØdegårdK.J. DahlA.A. BovimG. StovnerL.J. Depression and anxiety disorders associated with headache frequency. The Nord‐Trøndelag Health Study.Eur. J. Neurol.200310214715210.1046/j.1468‑1331.2003.00551.x12603289
     [Google Scholar]
  17. ZebenholzerK. LechnerA. BroessnerG. LamplC. LuthringshausenG. WuschitzA. ObmannS.M. BerekK. WöberC. Impact of depression and anxiety on burden and management of episodic and chronic headaches – a cross-sectional multicentre study in eight Austrian headache centres.J. Headache Pain20161711510.1186/s10194‑016‑0603‑326920681
     [Google Scholar]
  18. PesaJ. LageM.J. The medical costs of migraine and comorbid anxiety and depression.Headache200444656257010.1111/j.1526‑4610.2004.446004.x15186300
     [Google Scholar]
  19. AlonsoJ. LiuZ. Evans-LackoS. SadikovaE. SampsonN. ChatterjiS. AbdulmalikJ. Aguilar-GaxiolaS. Al-HamzawiA. AndradeL.H. BruffaertsR. CardosoG. CiaA. FlorescuS. de GirolamoG. GurejeO. HaroJ.M. HeY. de JongeP. KaramE.G. KawakamiN. Kovess-MasfetyV. LeeS. LevinsonD. Medina-MoraM.E. Navarro-MateuF. PennellB.E. PiazzaM. Posada-VillaJ. ten HaveM. ZarkovZ. KesslerR.C. ThornicroftG. Treatment gap for anxiety disorders is global: Results of the world mental health surveys in 21 countries.Depress. Anxiety201835319520810.1002/da.2271129356216
     [Google Scholar]
  20. SantomauroD.F. Mantilla HerreraA.M. ShadidJ. ZhengP. AshbaughC. PigottD.M. AbbafatiC. AdolphC. AmlagJ.O. AravkinA.Y. Bang-JensenB.L. BertolacciG.J. BloomS.S. CastellanoR. CastroE. ChakrabartiS. ChattopadhyayJ. CogenR.M. CollinsJ.K. DaiX. DangelW.J. DapperC. DeenA. EricksonM. EwaldS.B. FlaxmanA.D. FrostadJ.J. FullmanN. GilesJ.R. GirefA.Z. GuoG. HeJ. HelakM. HullandE.N. IdrisovB. LindstromA. LinebargerE. LotufoP.A. LozanoR. MagistroB. MaltaD.C. MånssonJ.C. MarinhoF. MokdadA.H. MonastaL. NaikP. NomuraS. O’HalloranJ.K. OstroffS.M. PasovicM. PenberthyL. ReinerR.C.Jr ReinkeG. RibeiroA.L.P. SholokhovA. SorensenR.J.D. VaravikovaE. VoA.T. WalcottR. WatsonS. WiysongeC.S. ZiglerB. HayS.I. VosT. MurrayC.J.L. WhitefordH.A. FerrariA.J. Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic.Lancet2021398103121700171210.1016/S0140‑6736(21)02143‑734634250
     [Google Scholar]
  21. NuttD. ArgyropoulosS. HoodS. PotokarJ. Generalized anxiety disorder: A comorbid disease.Eur Neuropsychopharmacol200616S2S109S118.1610.1016/j.euroneuro.2006.04.003
     [Google Scholar]
  22. BuoliM. CaldiroliA. CalettiE. PaoliR.A. AltamuraA.C. New approaches to the pharmacological management of generalized anxiety disorder.Expert Opin. Pharmacother.201314217518410.1517/14656566.2013.75955923282069
     [Google Scholar]
  23. BandelowB. ZoharJ. HollanderE. KasperS. MöllerH.J. BandelowB. ZoharJ. HollanderE. KasperS. MöllerH-J. AllgulanderC. Ayuso-GutierrezJ. BaldwinD.S. BuenviciusR. CassanoG. FinebergN. GabrielsL. HindmarchI. KaiyaH. KleinD.F. LaderM. LecrubierY. LépineJ.P. LiebowitzM.R. Lopez-IborJ.J. MarazzitiD. MiguelE.C. OhK.S. PreterM. RupprechtR. SatoM. StarcevicV. SteinD.J. van AmeringenM. VegaJ. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision.World J. Biol. Psychiatry20089424831210.1080/1562297080246580718949648
     [Google Scholar]
  24. MöhlerH. GABAA receptor diversity and pharmacology.Cell Tissue Res.2006326250551610.1007/s00441‑006‑0284‑316937111
     [Google Scholar]
  25. Uusi-OukariM. KorpiE.R. Regulation of GABA(A) receptor subunit expression by pharmacological agents.Pharmacol. Rev.20106219713510.1124/pr.109.00206320123953
     [Google Scholar]
  26. MenifL. OueslatiB. MaamriA. MelkiW. ZalilaH. Correlates of benzodiazepine dependence in patients with depression followed up in a psychiatric outpatient unit in Tunisia.J. Ethn. Subst. Abuse202120110411610.1080/15332640.2019.158961130983538
     [Google Scholar]
  27. BaoX. YeT. WangX. HanL. WangT. QiD. WangX. ChengX-R. The molecular mechanisms of suanzaoren prescription for anti-anxiety were investigated based on network pharmacology.Research Square202110.21203/rs.3.rs‑719079/v1
     [Google Scholar]
  28. DolatiS. RikhtegarR. MehdizadehA. YousefiM. The role of magnesium in pathophysiology and migraine treatment.Biol. Trace Elem. Res.2020196237538310.1007/s12011‑019‑01931‑z31691193
     [Google Scholar]
  29. Levi-MontalciniR. HamburgerV. Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo.J. Exp. Zool.1951116232136110.1002/jez.140116020614824426
     [Google Scholar]
  30. BardeY.A. EdgarD. ThoenenH. Purification of a new neurotrophic factor from mammalian brain.EMBO J.19821554955310.1002/j.1460‑2075.1982.tb01207.x7188352
     [Google Scholar]
  31. MaisonpierreP.C. BelluscioL. SquintoS. IpN.Y. FurthM.E. LindsayR.M. YancopoulosG.D. Neurotrophin-3: A neurotrophic factor related to NGF and BDNF.Science199024749491446145110.1126/science.23210062321006
     [Google Scholar]
  32. HallböökF. IbáñezC.F. PerssonH. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary.Neuron19916584585810.1016/0896‑6273(91)90180‑82025430
     [Google Scholar]
  33. IpN.Y. IbáñezC.F. NyeS.H. McClainJ. JonesP.F. GiesD.R. BelluscioL. Le BeauM.M. EspinosaR.III SquintoS.P. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.Proc. Natl. Acad. Sci. USA19928973060306410.1073/pnas.89.7.30601313578
     [Google Scholar]
  34. BinderD.K. ScharfmanH.E. Brain-derived neurotrophic factor.Growth Factors200422312313110.1080/0897719041000172330815518235
     [Google Scholar]
  35. Levi-MontalciniR. The nerve growth factor: Its mode of action on sensory and sympathetic nerve cells.Harvey Lect.196660217259
     [Google Scholar]
  36. HohnA. LeibrockJ. BaileyK. BardeY.A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family.Nature1990344626433934110.1038/344339a02314473
     [Google Scholar]
  37. MetsisM. TimmuskT. ArenasE. PerssonH. Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.Proc. Natl. Acad. Sci.199390198802880610.1073/pnas.90.19.88028415610
     [Google Scholar]
  38. TimmuskT. PalmK. MetsisM. ReintamT. PaalmeV. SaarmaM. PerssonH. Multiple promoters direct tissue-specific expression of the rat BDNF gene.Neuron199310347548910.1016/0896‑6273(93)90335‑O8461137
     [Google Scholar]
  39. TanakaJ. HoriikeY. MatsuzakiM. MiyazakiT. Ellis-DaviesG.C.R. KasaiH. Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.Science200831958701683168710.1126/science.115286418309046
     [Google Scholar]
  40. HorchH.W. KatzL.C. BDNF release from single cells elicits local dendritic growth in nearby neurons.Nat. Neurosci.20025111177118410.1038/nn92712368805
     [Google Scholar]
  41. FigurovA. Pozzo-MillerL.D. OlafssonP. WangT. LuB. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus.Nature1996381658470670910.1038/381706a08649517
     [Google Scholar]
  42. KangH. SchumanE.M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus.Science199526752041658166210.1126/science.78864577886457
     [Google Scholar]
  43. YamadaK. MizunoM. NabeshimaT. Role for brain-derived neurotrophic factor in learning and memory.Life Sci.200270773574410.1016/S0024‑3205(01)01461‑811833737
     [Google Scholar]
  44. EganM.F. KojimaM. CallicottJ.H. GoldbergT.E. KolachanaB.S. BertolinoA. ZaitsevE. GoldB. GoldmanD. DeanM. LuB. WeinbergerD.R. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Cell2003112225726910.1016/S0092‑8674(03)00035‑712553913
     [Google Scholar]
  45. CathomasF. VoglerC. Euler-SigmundJ.C. de QuervainD.J.F. PapassotiropoulosA. Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory.Int. J. Neuropsychopharmacol.201013897598010.1017/S146114571000051920482942
     [Google Scholar]
  46. XuB. GouldingE.H. ZangK. CepoiD. ConeR.D. JonesK.R. TecottL.H. ReichardtL.F. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.Nat. Neurosci.20036773674210.1038/nn107312796784
     [Google Scholar]
  47. CaoL. LinE.J.D. CahillM.C. WangC. LiuX. DuringM.J. Molecular therapy of obesity and diabetes by a physiological autoregulatory approach.Nat. Med.200915444745410.1038/nm.193319270710
     [Google Scholar]
  48. NagaharaA.H. TuszynskiM.H. Potential therapeutic uses of BDNF in neurological and psychiatric disorders.Nat. Rev. Drug Discov.201110320921910.1038/nrd336621358740
     [Google Scholar]
  49. ErnforsP. WetmoreC. OlsonL. PerssonH. Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family.Neuron19905451152610.1016/0896‑6273(90)90090‑32206535
     [Google Scholar]
  50. HoferM. PagliusiS.R. HohnA. LeibrockJ. BardeY.A. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.EMBO J.1990982459246410.1002/j.1460‑2075.1990.tb07423.x2369898
     [Google Scholar]
  51. ConnerJ.M. LauterbornJ.C. YanQ. GallC.M. VaronS. Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: Evidence for anterograde axonal transport.J. Neurosci.19971772295231310.1523/JNEUROSCI.17‑07‑02295.19979065491
     [Google Scholar]
  52. YanQ. RosenfeldR.D. MathesonC.R. HawkinsN. LopezO.T. BennettL. WelcherA.A. Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system.Neuroscience199778243144810.1016/S0306‑4522(96)00613‑69145800
     [Google Scholar]
  53. Katoh-SembaR. TakeuchiI.K. SembaR. KatoK. Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain.J. Neurochem.1997691344210.1046/j.1471‑4159.1997.69010034.x9202291
     [Google Scholar]
  54. GorbaT. KlostermannO. WahleP. Development of neuronal activity and activity-dependent expression of brain-derived neurotrophic factor mRNA in organotypic cultures of rat visual cortex.Cereb. Cortex19999886487710.1093/cercor/9.8.86410601005
     [Google Scholar]
  55. PatzS. WahleP. Developmental changes of neurotrophin mRNA expression in the layers of rat visual cortex.Eur. J. Neurosci.20062492453246010.1111/j.1460‑9568.2006.05126.x17100834
     [Google Scholar]
  56. AdachiN. NumakawaT. RichardsM. NakajimaS. KunugiH. New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases.World J. Biol. Chem.20145440942810.4331/wjbc.v5.i4.40925426265
     [Google Scholar]
  57. AidT. KazantsevaA. PiirsooM. PalmK. TimmuskT. Mouse and rat BDNF gene structure and expression revisited.J. Neurosci. Res.200785352553510.1002/jnr.2113917149751
     [Google Scholar]
  58. PruunsildP. KazantsevaA. AidT. PalmK. TimmuskT. Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters.Genomics200790339740610.1016/j.ygeno.2007.05.00417629449
     [Google Scholar]
  59. BarkerP.A. Whither proBDNF?Nat. Neurosci.200912210510610.1038/nn0209‑10519172162
     [Google Scholar]
  60. AzimovaJ. KondratievaN. CepгeeвA.B. The role of BDNF gene polymorphism in formation of clinical characteristics of migraine.J. Neurol. Stroke20164210.15406/jnsk.2016.04.00123
     [Google Scholar]
  61. FischerM. WilleG. KlienS. ShanibH. HolleD. GaulC. BroessnerG. Brain-derived neurotrophic factor in primary headaches.J. Headache Pain201213646947510.1007/s10194‑012‑0454‑522584531
     [Google Scholar]
  62. CaiX. ShiX. ZhangX. ZhangA. ZhengM. FangY. The association between brain-derived neurotrophic factor gene polymorphism and migraine: A meta-analysis.J. Headache Pain20171811310.1186/s10194‑017‑0725‑228150221
     [Google Scholar]
  63. LuB. PangP.T. WooN.H. The yin and yang of neurotrophin action.Nat. Rev. Neurosci.20056860361410.1038/nrn172616062169
     [Google Scholar]
  64. MinichielloL. TrkB. TrkB signalling pathways in LTP and learning.Nat. Rev. Neurosci.2009101285086010.1038/nrn273819927149
     [Google Scholar]
  65. MatsumotoT. RauskolbS. PolackM. KloseJ. KolbeckR. KorteM. BardeY.A. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.Nat. Neurosci.200811213113310.1038/nn203818204444
     [Google Scholar]
  66. DieniS. MatsumotoT. DekkersM. RauskolbS. IonescuM.S. DeograciasR. GundelfingerE.D. KojimaM. NestelS. FrotscherM. BardeY.A. BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons.J. Cell Biol.2012196677578810.1083/jcb.20120103822412021
     [Google Scholar]
  67. EdelmannE. LeßmannV. BrigadskiT. Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity.Neuropharmacology201476Pt C61062710.1016/j.neuropharm.2013.05.043
     [Google Scholar]
  68. ErnforsP. LeeK.F. JaenischR. Mice lacking brain-derived neurotrophic factor develop with sensory deficits.Nature1994368646714715010.1038/368147a08139657
     [Google Scholar]
  69. LommatzschM. BraunA. MannsfeldtA. BotchkarevV.A. BotchkarevaN.V. PausR. FischerA. LewinG.R. RenzH. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia.Am. J. Pathol.199915541183119310.1016/S0002‑9440(10)65221‑210514401
     [Google Scholar]
  70. FujimuraH. ChenR. NakamuraT. NakahashiT. KambayashiJ. SunB. AltarC. TandonN. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation.Thromb. Haemost.200287472873410.1055/s‑0037‑161307212008958
     [Google Scholar]
  71. JiangH. ChenS. LiC. LuN. YueY. YinY. ZhangY. ZhiX. ZhangD. YuanY. The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment.Transl. Psychiatry201774e1079e107910.1038/tp.2017.4328375203
     [Google Scholar]
  72. BorbaE.M. DuarteJ.A. BristotG. ScottonE. CamozzatoA.L. ChavesM.L.F. Brain-derived neurotrophic factor serum levels and hippocampal volume in mild cognitive impairment and dementia due to alzheimer disease.Dement. Geriatr. Cogn. Disord. Extra20166355956710.1159/00045060128101102
     [Google Scholar]
  73. Galvez-ContrerasA.Y. Campos-OrdonezT. Lopez-VirgenV. Gomez-PlascenciaJ. Ramos-ZunigaR. Gonzalez-PerezO. Growth factors as clinical biomarkers of prognosis and diagnosis in psychiatric disorders.Cytokine Growth Factor Rev.201632859610.1016/j.cytogfr.2016.08.00427618303
     [Google Scholar]
  74. AutryA.E. MonteggiaL.M. Brain-derived neurotrophic factor and neuropsychiatric disorders.Pharmacol. Rev.201264223825810.1124/pr.111.00510822407616
     [Google Scholar]
  75. KaregeF. SchwaldM. CisseM. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets.Neurosci. Lett.2002328326126410.1016/S0304‑3940(02)00529‑312147321
     [Google Scholar]
  76. SartoriusA. HellwegR. LitzkeJ. VogtM. DormannC. VollmayrB. Danker-HopfeH. GassP. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats.Pharmacopsychiatry200942627027610.1055/s‑0029‑122416219924587
     [Google Scholar]
  77. BuseD.C. ReedM.L. FanningK.M. BosticR. DodickD.W. SchwedtT.J. MunjalS. SinghP. LiptonR.B. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: Results of the migraine in America symptoms and treatment (MAST) study.J. Headache Pain20202112310.1186/s10194‑020‑1084‑y32122324
     [Google Scholar]
  78. HolmuratovaB. RashidovaN. KhalimovaK. MatmurodovR. RakhmatullaevaG. The role of BDNF in the clinical course of primary headaches.Cephalalgia Rep.202362515816323119029210.1177/25158163231190292
     [Google Scholar]
  79. DuanS. RenZ. XiaH. WangZ. ZhengT. LiG. LiuL. LiuZ. Associations between anxiety, depression with migraine, and migraine-related burdens.Front. Neurol.202314109087810.3389/fneur.2023.109087837181566
     [Google Scholar]
  80. GorkaS.M. TeppenT. RadomanM. PhanK.L. PandeyS.C. Human plasma BDNF is associated with amygdala-prefrontal cortex functional connectivity and problem drinking behaviors.Int. J. Neuropsychopharmacol.202023111110.1093/ijnp/pyz05731722379
     [Google Scholar]
  81. KleinA.B. WilliamsonR. SantiniM.A. ClemmensenC. EttrupA. RiosM. KnudsenG.M. AznarS. Blood BDNF concentrations reflect brain-tissue BDNF levels across species.Int. J. Neuropsychopharmacol.201114334735310.1017/S146114571000073820604989
     [Google Scholar]
  82. AltamuraC. CorbelliI. de TommasoM. Di LorenzoC. Di LorenzoG. Di RenzoA. FilippiM. JanniniT.B. MessinaR. ParisiP. ParisiV. PierelliF. RaineroI. RaucciU. RubinoE. SarchielliP. LiL. VernieriF. VollonoC. CoppolaG. Pathophysiological bases of comorbidity in migraine.Front. Hum. Neurosci.20211564057410.3389/fnhum.2021.64057433958992
     [Google Scholar]
  83. SudershanA. MahajanK. SinghK. DharM.K. KumarP. The complexities of migraine: A debate among migraine researchers: A review.Clin. Neurol. Neurosurg.202221410713610.1016/j.clineuro.2022.10713635101780
     [Google Scholar]
  84. ZhaoZ. JinH. YinY. HouY. WangJ. TangC. FuJ. Association of migraine with its comorbidities and food specific immunoglobulin g antibodies and inflammatory cytokines: Cross-sectional clinical research.J. Pain Res.2021142359236810.2147/JPR.S31661934385841
     [Google Scholar]
  85. ZarneshanS.N. FakhriS. KhanH. Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach.Pharmacol. Res.202217710609910.1016/j.phrs.2022.10609935092819
     [Google Scholar]
  86. Lima GiacobboB. DoorduinJ. KleinH.C. DierckxR.A.J.O. BrombergE. de VriesE.F.J. Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation.Mol. Neurobiol.20195653295331210.1007/s12035‑018‑1283‑630117106
     [Google Scholar]
  87. SzklarczykD. GableA.L. LyonD. JungeA. WyderS. Huerta-CepasJ. SimonovicM. DonchevaN.T. MorrisJ.H. BorkP. JensenL.J. MeringC. STRING v11: Protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.Nucleic Acids Res.201947D1D607D61310.1093/nar/gky113130476243
     [Google Scholar]
  88. AminF.M. AristeidouS. BaraldiC. Czapinska-CiepielaE.K. AriadniD.D. Di LenolaD. FenechC. KampourisK. KaragiorgisG. BraschinskyM. LindeM. The association between migraine and physical exercise.J. Headache Pain20181918310.1186/s10194‑018‑0902‑y30203180
     [Google Scholar]
  89. NeriL.C.L. FerrarisC. CatalanoG. GuglielmettiM. PascaL. PezzottiE. CarpaniA. TagliabueA. Ketosis and migraine: A systematic review of the literature and meta-analysis.Front. Nutr.202310120470010.3389/fnut.2023.120470037377485
     [Google Scholar]
  90. NourollahimoghadamE. GorjiS. GorjiA. Khaleghi GhadiriM. Therapeutic role of yoga in neuropsychological disorders.World J. Psychiatry2021111075477310.5498/wjp.v11.i10.75434733640
     [Google Scholar]
  91. ZhouC. ZhongJ. ZouB. FangL. ChenJ. DengX. ZhangL. ZhaoX. QuZ. LeiY. LeiT. Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression.PLoS One2017122e017227010.1371/journal.pone.017227028241064
     [Google Scholar]
  92. KangM.J.Y. HawkenE. VazquezG.H. The mechanisms behind rapid antidepressant effects of ketamine: A systematic review with a focus on molecular neuroplasticity.Front. Psychiatry20221386088210.3389/fpsyt.2022.86088235546951
     [Google Scholar]
  93. WeiH.L. WeiC. FengY. YanW. YuY.S. ChenY.C. YinX. LiJ. ZhangH. Predicting the efficacy of non-steroidal anti-inflammatory drugs in migraine using deep learning and three-dimensional T1-weighted images.iScience2023261110810710.1016/j.isci.2023.10810737867961
     [Google Scholar]
  94. KinreichS. McCutcheonV.V. AlievF. MeyersJ.L. KamarajanC. PandeyA.K. ChorlianD.B. ZhangJ. KuangW. PandeyG. ViteriS.S.S. FrancisM.W. ChanG. BourdonJ.L. DickD.M. AnokhinA.P. BauerL. HesselbrockV. SchuckitM.A. NurnbergerJ.I.Jr ForoudT.M. SalvatoreJ.E. BucholzK.K. PorjeszB. Predicting alcohol use disorder remission: A longitudinal multimodal multi-featured machine learning approach.Transl. Psychiatry202111116610.1038/s41398‑021‑01281‑233723218
     [Google Scholar]
  95. PeeleK.A. Potla DurthiC. SrihansaT. KrupanidhiS. AyyagariV.S. BabuD.J. IndiraM. ReddyA.R. VenkateswaruluT.C. Molecular docking and dynamic simulations for antiviral compounds against SARS-CoV-2: A computational study.Informatics in Medicine Unlocked20201910034510.1016/j.imu.2020.10034532395606
     [Google Scholar]
  96. FriesnerR.A. BanksJ.L. MurphyR.B. HalgrenT.A. KlicicJ.J. MainzD.T. RepaskyM.P. KnollE.H. ShelleyM. PerryJ.K. ShawD.E. FrancisP. ShenkinP.S. Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy.J. Med. Chem.20044771739174910.1021/jm030643015027865
     [Google Scholar]
  97. LoganathanL. MuthusamyK. JayarajJ.M. KajamaideenA. BalthasarJ.J. In silico insights on tankyrase protein: A potential target for colorectal cancer.J. Biomol. Struct. Dyn.201937143637364810.1080/07391102.2018.152174830204055
     [Google Scholar]
  98. MuthusamyK. KrishnasamyG. A computational study on role of 6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol in the regulation of blood glucose level.J. Biomol. Struct. Dyn.20161212010.1080/07391102.2015.1124289
     [Google Scholar]
  99. LoganathanL. NatarajanK. MuthusamyK. Computational study on cross-talking cancer signalling mechanism of ring finger protein 146, AXIN and Tankyrase protein complex.J. Biomol. Struct. Dyn.202038175173518510.1080/07391102.2019.169670731760854
     [Google Scholar]
  100. LoganathanL. KuriakoseB.B. MushfiqS. MuthusamyK. Mechanistic insights on nsSNPs on binding site of renin and cytochrome P450 proteins: A computational perceptual study for pharmacogenomics evaluation.J. Cell. Biochem.2021122101460147410.1002/jcb.3006934161641
     [Google Scholar]
  101. JayarajJ.M. KuriakoseB.B. AlhazmiA.H. MuthusamyK. Structural and functional insights on vitamin D receptor and CYP24A1 deleterious single nucleotide polymorphisms: A computational and pharmacogenomics perpetual approach.Cell Biochem. Funct.202139787488510.1002/cbf.365834231237
     [Google Scholar]
  102. GuptaN. ChoudharyS.K. BhagatN. KarthikeyanM. ChaturvediA. In silico prediction, molecular docking and dynamics studies of steroidal alkaloids of holarrhena pubescens wall. ex G. Don to guanylyl cyclase C: Implications in designing of novel antidiarrheal therapeutic strategies.Molecules20212614414710.3390/molecules2614414734299422
     [Google Scholar]
  103. LoganathanL. BrigetK.B. SampayanL.E. MuthusamyK. Targeting renin receptor for the inhibition of renin angiotensin aldosterone system: An alternative approach through in silico drug discovery.Comput. Theor. Chem.2022120811354111354110.1016/j.comptc.2021.113541
     [Google Scholar]
  104. JayarajJ.M. RetetiE. KesavanC. MuthusamyK. Structural insights on vitamin D receptor and screening of new potent agonist molecules: Structure and ligand-based approach.J. Biomol. Struct. Dyn.202139114148415910.1080/07391102.2020.177512232462983
     [Google Scholar]
  105. John MarshalJ. KuriakoseB.B. AlhazmiA.H. MuthusamyK. Mechanistic insights into the role of vitamin D and computational identification of potential lead compounds for Parkinson’s disease.J. Cell. Biochem.2023124343444510.1002/jcb.3037936780350
     [Google Scholar]
  106. KandasamyS. SelvarajM. MuthusamyK. VaradarajuN. KannupalS. SekarA.K. VilwanathanR. Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes.J. Biomol. Struct. Dyn.202211410.1080/07391102.2021.202425434994284
     [Google Scholar]
  107. ChinnasamyS. NagamaniS. MuthusamyK. Zn 2+ ion of the snake venom metalloproteinase (SVMP) plays a critical role in ligand binding: A molecular dynamics simulation study.RSC Advances2015586705667057610.1039/C5RA14693C
     [Google Scholar]
  108. RamakrishnanP. Pandiselvi Pandi; Muralidharan Jothimani; Sakthi Sasikala Sundaravel; Karthikeyan Muthusamy; Narayanan, U.; Mehboobali Pannipara; Al-Sehemi, A.G.; Jayaraman, A. Computational Approach on Moringa Oleifera as an Inhibitor against SARS-CoV-2 Structural Proteins.Indian Journal of Biochemistry and Biophysics (IJBB).2023601294195710.56042/ijbb.v60i12.6278
     [Google Scholar]
/content/journals/lddd/10.2174/0115701808274096231207042744
Loading
Computational Insights on Migraine and Anxiety in Association with BDNF
Letters in Drug Design & Discovery 21, 3389 (2024); https://doi.org/10.2174/0115701808274096231207042744
/content/journals/lddd/10.2174/0115701808274096231207042744
/content/journals/lddd/10.2174/0115701808274096231207042744
Loading

Data & Media loading...

Supplements

Supplementary material is available on the publisher's website along with the published article.

file format download Download

  • Article Type:     Research Article
Keyword(s): ADME/T predictions; anxiety; DFT analysis; Migraine; molecular dynamics simulations; structure-based virtual screening

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test