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Volume 21, Issue 15
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background

Consumption of a high-fat diet (HFD) is one of the main causes of non-alcoholic fatty liver disease (NAFLD), which is increasing due to lifestyle changes and is still an important global health issue. Despite the efforts, there is still no common treatment for this disease. Studies have shown that the root of Janisch has a hypolipidemic effect and a significant antioxidant effect on liver tissue in diabetic rats. However, no experimental study has been performed on the hepatoprotective effects of this herb on HFD-induced NAFLD have been proven.

Objective

This study aimed to evaluate the effect of Janisch extract (RTE) on HFD-induced NAFLD in BALB/c mice.

Materials and Methods

The study was performed with two models of prevention and therapeutic effect of RTE. Serum biochemical markers, histopathology, oxidative stress indicators, and qRT-PCR were measured to evaluate the effects of RTE on lipid metabolism disorders in mice feeding with HFD.

Results

In the prevention model, compared to the HFD group, RTE treatment decreased the levels of glucose, triglyceride, and cholesterol and improved liver profile markers, oxidative stress, and expression of genes involved in lipid metabolism.

Conclusion

The results of this study suggest that RTE has hepatoprotective effects against HFD-induced liver damage by reducing oxidative stress, lipogenesis, and increasing beta-oxidation of free fatty acids.

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2025-07-14

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/content/journals/lddd/10.2174/0115701808248646231102075104
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Hepatoprotective Effects of Rheum turkestanicum Janisch on High-fat Diet-induced Non-alcoholic Fatty Liver Disease in Mice
Letters in Drug Design & Discovery 21, 3134 (2024); https://doi.org/10.2174/0115701808248646231102075104
/content/journals/lddd/10.2174/0115701808248646231102075104
/content/journals/lddd/10.2174/0115701808248646231102075104
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  • Article Type:     Research Article
Keyword(s): beta-oxidation; High-fat diet; lipogenesis; non-alcoholic fatty liver disease; oxidative stress; Rheum turkestanicum janisch

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