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- Volume 20, Issue 1, 2020
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders) - Volume 20, Issue 1, 2020
Volume 20, Issue 1, 2020
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Sofosbuvir: Really Meets the Unmet Needs for Hepatitis C Treatment?
Authors: Deepti Chopra and Bharti BhandariChronic hepatitis C remains a major public health concern with a prevalence of more than 1% worldwide. Of late, with the discovery of newer drugs, chronic HCV treatment has touched new dimensions. The treatment has progressed from Interferons to Pegylated interferon (Peg IFN) based therapy, with or without ribavirin to treatment with orally active Direct Acting Antivirals (DAA) with Peg IFN and ribavirin and event Read More
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A Review on Free Radicals and Antioxidants
More LessFree radicals are generated in our body by several systems. A balance among free radicals and antioxidants is an important matter for appropriate physiological function. If free radicals become greater than the ability of the body to control them, a case known as oxidative stress appears, as a result of that, a number of human diseases spread in the body. Antioxidants can contribute to facingthis oxidative stress. The present re Read More
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Review on the Characteristic, Properties and Analytical Methods of Cefquinomesulphate: ß-lactam Veterinary Drug
More LessBackground: Chemotherapy as a science began within the 1st decade of the twentieth century with understanding of the principles of selective toxicity, the particular chemical relationships between microorganism pathogens and medicines, the event of drug resistance, and also the role of combined medical aid. Objectives: This review aims to highlight the characteristics, specifically the pharmacokinetic parameters and the Read More
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Pharmaco-Audiology Vigilance in the Treatment of Adult Patients with HIV/Aids: Ototoxicity Monitoring Protocol Recommendation
More LessSouth Africa is considered the epicenter of HIV/AIDS with a high rate of TB infection as well. Links have been established between treatments of these conditions to ototoxicity. However, no standardized and systematic ototoxicity monitoring exists within the clinical sites where these conditions are treated, with very minimal and adhoc involvement of audiologists as part of the treatment team. With 3.4 million HIV-infe Read More
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Real Life Egyptian Experience of Daclatasvir Plus Sofosbuvir with Ribavirin in Naïve Difficult to Treat HCV Patients
Authors: Engy A. Wahsh, Amal K. Hussein, Ahmed A. Gomaa, Mohamed A. Baraka and Mohie Al-deen AbeadBackground: Chronic infection with Hepatitis C virus (HCV) is considered as a major cause for developing liver cirrhosis and hepatocellular carcinoma. A new era in HCV treatment is ongoing using Direct Acting Antiviral activity (DAA). The first approved DAA drug was Sofosbuvir which has a high tolerability and preferable pharmacokinetic profile. Another recently developed drug is Daclatasvir a first-in-class HCV NS5A r Read More
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Plasmid-Mediated Quinolone Resistance in Pseudomonas aeruginosa Isolated from Burn Patients in Tehran, Iran
Introduction: Plasmid-induced quinolone resistance has raised a great concern in the treatment of serious infections worldwide. The aims of this study were to determine the antibiotic susceptibility, the frequency of qepA, aac(6')-Ib and qnr genes by PCR and sequencing, and typing of the resistant isolates using repetitive extragenic palindromic sequence-based PCR (REPPCR) in Pseudomonas aeruginosa isolated from burn Read More
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Phenotypic and Molecular Survey of Metallo-beta-lactamase-producing Pseudomonas aeruginosa Isolated from Patients with Nosocomial and Non-Nosocomial Infections
Authors: Samaneh Rouhi and Rashid RamazanzadehBackground: Resistance to antimicrobial agents in Pseudomonas aeruginosa (P. aeruginosa) including carbapenems is a prominent problem in patients. The aim of this study is surveying Metallo-beta-lactamase (MBL)-producing P. aeruginosa isolated from patient specimens with nosocomial and non-nosocomial infections in Kurdistan province, Iran. Methods: In total, 146 Pseudomonas spp. were collected (December 2015 to Read More
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Evaluation of Salivary Lipid Peroxidation End Product Level in Dental Caries
Authors: Fatemeh Ahmadi-Motamayel, Seyede S. Hendi and Mohammad Taghi GoodarziBackground: Tissue destruction can be measured by the level of lipid peroxidation (LP) end products. Since free radicals are very reactive with low survival time, the level of free radicals and oxidative stress activity are measured indirectly by tissue damage end product assessment, i.e. Malondialdehyde (MDA) that is a final end product of LP. Objective: The aim of this study was to evaluate salivary MDA level as an indicat Read More
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Novel Compound from Flowers of Moringa oleifera Active Against Multi-Drug Resistant Gram-negative Bacilli
Background: The need for suitable antibacterial agents effective against Multi-drug resistant Gram-negative bacteria is acknowledged globally. The present study was designed to evaluate the possible antibacterial potential of an extracted compound from edible flowers of Moringa oleifera. Methods: Five different solvents were used for preparing dried flower extracts. The most effective extract was subjected to fractionation Read More
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Application of SRMS 154 as Sustained Release Matrix for the Delivery of Stavudine: In vitro and in vivo Evaluation and Effect of Poloxamer 188 on the Properties of the Tablets
Authors: S.A. Chime, A.A. Attama and G.C. OnunkwoBackground: Stavudine is an antiretroviral therapy with so many side effects and has a short half-life of 1.5 h. It degrades to thymine under hydrolytic, oxidative and photolytic conditions hence has major formulation challenges. Objectives: To formulate sustained release lipid based stavudine and to study the properties of the formulations by in vitro and in vivo methods. Methods: Stavudine tablets were formulated b Read More
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Symptoms of Toxicity and Plasma Cytochrome c Levels in Human Immunodeficiency Virus-infected Patients Receiving Anti-retroviral Therapy in Ghana: A Cross-sectional Study
Authors: Eric A. Mensah, Bismark Sarfo, Evelyn Y. Bonney, Prince K. Parbie and Augustine OclooBackground: Side effects and toxicity have posed a threat to the positive contribution of Antiretroviral Therapy (ART) in the management of human immunodeficiency virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS). Symptoms of mitochondrial toxicity including myopathy, pancreatitis, hyperlipidaemia and lactic acidosis are found among HIVinfected patients on ART. To date, there is not a reliable biomarker Read More
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Trichomonas Vaginalis Infection Among Women Attending Laboratory Centers in Ilam, Iran
Authors: Sasan Nikpay, Masoumeh Otaghi, Milad Azami, Marzieh Karimi and Jahangir AbdiBackground: Trichomoniasis is known as a common venereal disease. It is estimated that 180 million people in the world are infected with this disease. The present study was conducted to estimate the prevalence of (Trichomonas vaginalis) T. vaginalis among women who were referred to the central laboratory in Ilam. Methods: In this cross-sectional study, 481 women with suspicious symptoms of trichomoniasis were selec Read More
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Multiple Myeloma or Brucellosis: A Case Report
Background: Brucellosis, a major health problem in developing countries, is a multisystem infection with a broad spectrum of clinical manifestations. Hematological complications, ranging from an intravascular coagulopathy to mild homeostasis disorders (such as gammopathy), have been reported in brucella infection. These signs and symptoms may lead to misdiagnosis of brucellosis with other hematological di Read More
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Burkholderia Cepacia Complex Causing Pneumonia in an Immunocompetent Non-Cystic Fibrosis Patient: Case Report and Review of Literature
Authors: Priya Datta, Menal Gupta, Mani B. Kumar, Varsha Gupta and Jagdish ChanderBackground: Burkholderia cepacia complex is widespread in the environment and has been recognized as a cause of opportunistic pulmonary infections, particularly in patients with Cystic Fibrosis (CF). The natural ecology of the bacteria as part of plant growth-promoting rhizosphere provides stark contrast to its infectious potential. Its preponderance as a nosocomial pathogen may be due to its ability to survive in anti Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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