Skip to content
2000
image of The Relationship among SARS-CoV-2, Vaccine Spike Protein, Renin-Angiotensin System, and Epilepsy
Preview this fast track article:

There is no abstract available.

Loading

Article metrics loading...

/content/journals/iddt/10.2174/0118715265350339240919053408
2024-09-22
2024-11-26
Loading full text...

Full text loading...

References

  1. World Health Organization Epilepsy. 2024 Available from: https://www.who.int/news-room/fact-sheets/detail/epilepsy
  2. Ooi Q.Y. Qin X. Yuan Y. Zhang X. Yao Y. Hao H. Li L. Alteration of excitation/inhibition imbalance in the hippocampus and amygdala of drug-resistant epilepsy patients treated with acute vagus nerve stimulation. Brain Sci. 2023 13 7 976 10.3390/brainsci13070976 37508908
    [Google Scholar]
  3. Anwar H. Khan Q.U. Nadeem N. Pervaiz I. Ali M. Cheema F.F. Epileptic seizures. Discoveries 2020 8 2 e110 10.15190/d.2020.7 32577498
    [Google Scholar]
  4. Chen Z. Brodie M.J. Ding D. Kwan P. Editorial: Epidemiology of epilepsy and seizures. Frontiers in Epidemiology 2023 3 1273163 10.3389/fepid.2023.1273163 38455942
    [Google Scholar]
  5. Fiest K.M. Sauro K.M. Wiebe S. Patten S.B. Kwon C.S. Dykeman J. Pringsheim T. Lorenzetti D.L. Jetté N. Prevalence and incidence of epilepsy. Neurology 2017 88 3 296 303 10.1212/WNL.0000000000003509 27986877
    [Google Scholar]
  6. Beghi E. Giussani G. Aging and the epidemiology of epilepsy. Neuroepidemiology 2018 51 3-4 216 223 10.1159/000493484 30253417
    [Google Scholar]
  7. International League Against Epilepsy Combined generalized and focal epilepsy. 2024 Available from: https://www.epilepsydiagnosis.org/epilepsy/focal-generalized-epilepsy-groupoverview.html
  8. National Health Service Epilepsy - Symptoms. 2017 Available from: https://www.nhs.uk/conditions/epilepsy/symptoms/
  9. Fajloun Z. Wu Y. Cao Z. Kovacic H. Sabatier J.M. COVID-19 and alzheimer’s disease: The link finally established. Infect. Disord. Drug Targets 2023 23 7 14 16 37254552
    [Google Scholar]
  10. Krasniqi S. Daci A. Role of the angiotensin pathway and its target therapy in epilepsy management. Int. J. Mol. Sci. 2019 20 3 726 10.3390/ijms20030726 30744022
    [Google Scholar]
  11. Fajloun Z. Sabatier J.M. The unsuspected role of the renin-angiotensin system (RAS): Could its dysregulation be at the root of all non-genetic human diseases? Infect. Disord. Drug Targets 2024 24 1 e140923221085 10.2174/1871526524666230914114524 37711109
    [Google Scholar]
  12. Dzau V.J. Bernstein K. Celermajer D. Cohen J. Dahlöf B. Deanfield J. Diez J. Drexler H. Ferrari R. van Gilst W. Hansson L. Hornig B. Husain A. Johnston C. Lazar H. Lonn E. Lüscher T. Mancini J. Mimran A. Pepine C. Rabelink T. Remme W. Ruilope L. Ruzicka M. Schunkert H. Swedberg K. Unger T. Vaughan D. Weber M. Working Group on Tissue Angiotensin-converting enzyme, International Society of Cardiovascular Pharmacotherapy The relevance of tissue angiotensin-converting enzyme: Manifestations in mechanistic and endpoint data. Am. J. Cardiol. 2001 88 9 1 20 10.1016/S0002‑9149(01)01878‑1 11694220
    [Google Scholar]
  13. Kaschina E. Unger T. Angiotensin AT1/AT2 receptors: Regulation, signalling and function. Blood Press. 2003 12 2 70 88 10.1080/08037050310001057 12797627
    [Google Scholar]
  14. Carey R.M. Update on the role of the AT2 receptor. Curr. Opin. Nephrol. Hypertens. 2005 14 1 67 71 10.1097/00041552‑200501000‑00011 15586018
    [Google Scholar]
  15. El-Arif G. Farhat A. Khazaal S. Annweiler C. Kovacic H. Wu Y. Cao Z. Fajloun Z. Khattar Z.A. Sabatier J.M. The renin-angiotensin system: A key role in sars-cov-2-induced covid-19. Molecules 2021 26 22 6945 10.3390/molecules26226945 34834033
    [Google Scholar]
  16. Annweiler C. Cao Z. Wu Y. Faucon E. Mouhat S. Kovacic H. Sabatier J.M. Counter-regulatory ‘renin-angiotensin’ system-based candidate drugs to treat covid-19 diseases in sars-cov-2-infected patients. Infect. Disord. Drug Targets 2020 20 4 407 408 10.2174/22123989MTA2cNzIlw 32418532
    [Google Scholar]
  17. El-Arif G. Khazaal S. Farhat A. Harb J. Annweiler C. Wu Y. Cao Z. Kovacic H. Abi Khattar Z. Fajloun Z. Sabatier J.M. Angiotensin I.I. Type I. Angiotensin II type i receptor (AT1R): The gate towards covid-19-associated diseases. Molecules 2022 27 7 2048 10.3390/molecules27072048 35408447
    [Google Scholar]
  18. Khazaal S. Harb J. Rima M. Annweiler C. Wu Y. Cao Z. Abi Khattar Z. Legros C. Kovacic H. Fajloun Z. Sabatier J.M. The pathophysiology of long covid throughout the renin-angiotensin system. Molecules 2022 27 9 2903 10.3390/molecules27092903 35566253
    [Google Scholar]
  19. Sabatier J-M. Fajloun Z. Legros C. Covid-19 and ehlers-danlos syndrome: The dangers of the spike protein of sars-cov-2. Infect. Disord. Drug Targets 2023 23 3 e040123212375 10.2174/1871526523666230104145108 36600622
    [Google Scholar]
  20. Fajloun Z. Abi Khattar Z. Kovacic H. Legros C. Sabatier J.M. Why do athletes develop very severe or fatal forms of covid after intense exercise following sars-cov-2 infection or anti-covid vaccination? Infect. Disord. Drug Targets 2023 23 4 e110123212563 10.2174/1871526523666230111104355 36631923
    [Google Scholar]
  21. Fajloun Z. Abi Khattar Z. Kovacic H. Legros C. Sabatier J.M. SIBO: The trail of a “new” human pathology associated with multiple severe and disabling covid-19 and long covid symptoms or induced by the anti-covid-19 vaccine. Infect. Disord. Drug Targets 2023 23 4 e100223213593 10.2174/1871526523666230210162334 36762752
    [Google Scholar]
  22. Fajloun Z. Abi Khattar Z. Kovacic H. Legros C. Sabatier J.M. Anti-covid-19 vaccination, covid-19, and female contraception: The exacerbated risks (thromboembolism) of the estrogen-progestin pill. Infect. Disord. Drug Targets 2023 23 4 e240223214000 10.2174/1871526523666230224094439 36823996
    [Google Scholar]
  23. Fajloun Z. Abi Khattar Z. Kovacic H. Legros C. Sabatier J.M. Understanding and relieving of neuropathic disorders in the long covid. Infect. Disord. Drug Targets 2023 23 4 e270223214061 10.2174/1871526523666230227113205 36843369
    [Google Scholar]
  24. Fajloun Z. Abi Khattar Z. Kovacic H. Sabatier J.M. Covid-19 and anti-covid-19 vaccination: potential damages to the thyroid gland. Infect. Disord. Drug Targets 2023 23 6 e090523216698 10.2174/1871526523666230509112038 37165584
    [Google Scholar]
  25. Fajloun Z. Wu Y. Cao Z. Kovacic H. Sabatier J.M. Covid-19 and parkinson’s disease: the link also established! Infect. Disord. Drug Targets 2023 37340743
    [Google Scholar]
  26. Fajloun Z. Khattar Z.A. Sabatier J.M. The intriguing connection between cholestasis and the renin-angiotensin system dysregulation induced by sars-cov-2 and/or the vaccinal spike protein. Infect. Disord. Drug Targets 2024 24 7 e080324227802 10.2174/0118715265304515240220105152 38465438
    [Google Scholar]
  27. Tajer L. Paillart J.C. Dib H. Sabatier J.M. Fajloun Z. Abi Khattar Z. Molecular mechanisms of bacterial resistance to antimicrobial peptides in the modern era: An updated review. Microorganisms 2024 12 7 1259 10.3390/microorganisms12071259 39065030
    [Google Scholar]
  28. Fajloun Z. Abi Khattar Z. Sabatier J.M. SARS-CoV-2 or vaccinal spike protein can induce mast cell activation syndrome (MCAS). Infect. Disord. Drug Targets 2024 24 1 3 38693735
    [Google Scholar]
  29. Fajloun Z. Tajer L. Khattar Z.A. Sabatier J.M. Unveiling the role of SARS-CoV-2 or mRNA vaccine spike protein in macrophage activation syndrome (MAS). Infect. Disord. Drug Targets 2024 24 39041264
    [Google Scholar]
  30. Quarleri J. Delpino M.V. SARS-CoV-2 interacts with renin-angiotensin system: Impact on the central nervous system in elderly patients. Geroscience 2022 44 2 547 565 10.1007/s11357‑022‑00528‑0 35157210
    [Google Scholar]
  31. Soltani Zangbar H. Gorji A. Ghadiri T. A review on the neurological manifestations of covid-19 infection: A mechanistic view. Mol. Neurobiol. 2021 58 2 536 549 10.1007/s12035‑020‑02149‑0 32981023
    [Google Scholar]
  32. Ivanova N. Tchekalarova J. The potential therapeutic capacity of inhibiting the brain renin–angiotensin system in the treatment of co-morbid conditions in epilepsy. CNS Drugs 2019 33 11 1101 1112 10.1007/s40263‑019‑00678‑4 31680223
    [Google Scholar]
  33. Cascella M. Rajnik M. Aleem A. Dulebohn S.C. Di Napoli R. Features, evaluation, and treatment of coronavirus (covid-19). StatPearls. Treasure Island, FL StatPearls Publishing 2024
    [Google Scholar]
  34. Al-Jamal H. Idriss S. Roufayel R. Abi Khattar Z. Fajloun Z. Sabatier J.M. Treating covid-19 with medicinal plants: Is it even conceivable? A comprehensive review. Viruses 2024 16 3 320 10.3390/v16030320 38543686
    [Google Scholar]
  35. Dong X. Fan J. Lin D. Wang X. Kuang H. Gong L. Chen C. Jiang J. Xia N. He D. Shen W. Jiang P. Kuang R. Zeng L. Xie Y. Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis. J. Neuroinflammation 2022 19 1 226 10.1186/s12974‑022‑02587‑8 36104755
    [Google Scholar]
  36. Gomes K.P. Braga P.P.P. de Lima C.Q. Jr Ghazale P.P. Pedrino G.R. Mendes E.P. Pansani A.P. Xavier C.H. Castro C.H. Colugnati D.B. Antiepileptic effects of long-term intracerebroventricular infusion of angiotensin-(1-7) in an animal model of temporal lobe epilepsy. Clin. Sci. 2020 134 17 2263 2277 10.1042/CS20200514 32803259
    [Google Scholar]
  37. Doege C. Luedde M. Kostev K. Association between angiotensin receptor blocker therapy and incidence of epilepsy in patients with hypertension. JAMA Neurol. 2022 79 12 1296 1302 10.1001/jamaneurol.2022.3413 36251288
    [Google Scholar]
/content/journals/iddt/10.2174/0118715265350339240919053408
Loading

  • Article Type:
    Editorial
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test