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Volume 25, Issue 2
  • ISSN: 1871-5265
  • E-ISSN: 2212-3989

Abstract

Aims

The present study aimed to assess the antibacterial effect of co-loaded rutin and curcumin in mesoporous silica nanoparticles (Cur-Rut-MSNs).

Background

Rutin is a nontoxic phytochemical that is present expansively in vegetables and fruits. Curcumin is an active ingredient of . Curcumin and rutin have a variety of therapeutic effects, essentially antimicrobial, anti-inflammatory, and antioxidant actions.

Objective

Low aqueous solubility and poor bioavailability of rutin and curcumin limit their application in therapeutic goals. One of the advantageous routes to improve their bioavailability and solubility is nanoformulation. Co-delivery of therapeutic agents has been reported to have better therapeutic effects than monotherapy.

Methods

The present study has evaluated the antibacterial properties of Cur-Rut-MSNs. The Minimum Inhibitory Concentration (MIC) of Cur-Rut-MSNs has been assessed against different bacteria.

Results

Cur-Rut-MSNs exerted significantly higher antibacterial effect than curcumin-loaded MSNs (Cur-MSNs) and rutin-loaded MSNs (Rut-MSNs) against , and (<0.05).

Conclusion

The antibacterial effect was enhanced by the co-loading of rutin and curcumin in MSNs. According to the findings of this study, Cur-Rut-MSNs exhibit an antibacterial effect and can be a favorable nanoformulation against planktonic bacteria.

© 2025 Bentham Science Publishers
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2024-09-20
2025-04-02

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References

  1. BehlT. KumarK. BriscC. Exploring the multifocal role of phytochemicals as immunomodulators.Biomed. Pharmacother.202113311095910.1016/j.biopha.2020.110959 33197758
     [Google Scholar]
  2. NwozoO.S. EffiongE.M. AjaP.M. AwuchiC.G. Antioxidant, phytochemical, and therapeutic properties of medicinal plants: A review.Int. J. Food Prop.202326135938810.1080/10942912.2022.2157425
     [Google Scholar]
  3. ZhangY.J. GanR.Y. LiS. Antioxidant phytochemicals for the prevention and treatment of chronic diseases.Molecules20152012211382115610.3390/molecules201219753 26633317
     [Google Scholar]
  4. NarasagoudrS.S. HegdeV.G. ChougaleR.B. MastiS.P. VootlaS. MalabadiR.B. Physico-chemical and functional properties of rutin induced chitosan/poly (vinyl alcohol) bioactive films for food packaging applications.Food Hydrocoll.202010910609610.1016/j.foodhyd.2020.106096
     [Google Scholar]
  5. GullónB. Lú-ChauT.A. MoreiraM.T. LemaJ.M. EibesG. Rutin: A review on extraction, identification and purification methods, biological activities and approaches to enhance its bioavailability.Trends Food Sci. Technol.20176722023510.1016/j.tifs.2017.07.008
     [Google Scholar]
  6. SharifiS. MoghaddamF.A. AbediA. Phytochemicals impact on osteogenic differentiation of mesenchymal stem cells.Biofactors202046687489310.1002/biof.1682 33037744
     [Google Scholar]
  7. SharmaS. AliA. AliJ. SahniJ.K. BabootaS. Rutin: Therapeutic potential and recent advances in drug delivery.Expert Opin. Investig. Drugs20132281063107910.1517/13543784.2013.805744 23795677
     [Google Scholar]
  8. KurienB.T. SinghA. MatsumotoH. ScofieldR.H. Improving the solubility and pharmacological efficacy of curcumin by heat treatment.Assay Drug Dev. Technol.20075456757610.1089/adt.2007.064 17767425
     [Google Scholar]
  9. KhalifaT.I. MuhtadiF.J. HassanM.M. Rutin, Analytical profiles of drug substances.AmsterdamElsevier198362368110.1016/S0099‑5428(08)60177‑X
     [Google Scholar]
  10. GaneshpurkarA. SalujaA.K. The pharmacological potential of rutin.Saudi Pharm. J.201725214916410.1016/j.jsps.2016.04.025 28344465
     [Google Scholar]
  11. NegahdariR. GhavimiM.A. BarzegarA. Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study.Clin. Exp. Dent. Res.20217216316910.1002/cre2.348 33210463
     [Google Scholar]
  12. SamieiM. AbediA. SharifiS. Maleki DizajS. Early osteogenic differentiation stimulation of dental pulp stem cells by calcitriol and curcumin.Stem Cells Int.202120211710.1155/2021/9980137 34122559
     [Google Scholar]
  13. SharifiS. Zaheri KhosroshahiA. Maleki DizajS. RezaeiY. Preparation, physicochemical assessment and the antimicrobial action of hydroxyapatite–gelatin/curcumin nanofibrous composites as a dental biomaterial.Biomimetics (Basel)202171410.3390/biomimetics7010004 35076470
     [Google Scholar]
  14. KangJ. LuX. ZengH. LiuH. LuB. Investigation on the electrochemistry of rutin and its analytical application.Anal. Lett.200235467768610.1081/AL‑120003169
     [Google Scholar]
  15. HooresfandZ. GhanbarzadehS. HamishehkarH. Preparation and characterization of rutin-loaded nanophytosomes.Pharm. Sci.201521314515110.15171/PS.2015.29
     [Google Scholar]
  16. Hamidi-AslE. RaoofJ.B. HejaziM.S. A genosensor for point mutation detection of P53 gene PCR product using magnetic particles.Electroanalysis20152761378138610.1002/elan.201400660
     [Google Scholar]
  17. AhireS.A. BachhavA.A. PawarT.B. JagdaleB.S. PatilA.V. KoliP.B. The augmentation of nanotechnology era: A concise review on fundamental concepts of nanotechnology and applications in material science and technology.Results Chem20222022100633
     [Google Scholar]
  18. Maleki DizajS. SharifiS. AhmadianE. EftekhariA. AdibkiaK. LotfipourF. An update on calcium carbonate nanoparticles as cancer drug/gene delivery system.Expert Opin. Drug Deliv.201916433134510.1080/17425247.2019.1587408 30807242
     [Google Scholar]
  19. HamidiA. SharifiS. DavaranS. GhasemiS. OmidiY. RashidiM-R. Novel aldehyde-terminated dendrimers; synthesis and cytotoxicity assay.Bioimpacts20122297103 23678447
     [Google Scholar]
  20. JoyeI.J. Davidov-PardoG. McClementsD.J. Nanotechnology for increased micronutrient bioavailability.Trends Food Sci. Technol.201440216818210.1016/j.tifs.2014.08.006
     [Google Scholar]
  21. KirtaneA.R. VermaM. KarandikarP. FurinJ. LangerR. TraversoG. Nanotechnology approaches for global infectious diseases.Nat. Nanotechnol.202116436938410.1038/s41565‑021‑00866‑8 33753915
     [Google Scholar]
  22. SahuT. RatreY.K. ChauhanS. BhaskarL.V.K.S. NairM.P. VermaH.K. Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science.J. Drug Deliv. Sci. Technol.20216310248710.1016/j.jddst.2021.102487
     [Google Scholar]
  23. LiJ. DingZ. LiY. Reactive oxygen species-sensitive thioketal-linked mesoporous silica nanoparticles as drug carrier for effective antibacterial activity.Mater. Des.202019510902110.1016/j.matdes.2020.109021
     [Google Scholar]
  24. ParkS.S. JungM.H. LeeY.S. BaeJ.H. KimS.H. HaC.S. Functionalised mesoporous silica nanoparticles with excellent cytotoxicity against various cancer cells for pH-responsive and controlled drug delivery.Mater. Des.201918410818710.1016/j.matdes.2019.108187
     [Google Scholar]
  25. RazaA. SimeF.B. CabotP.J. MaqboolF. RobertsJ.A. FalconerJ.R. Solid nanoparticles for oral antimicrobial drug delivery: A review.Drug Discov. Today201924385886610.1016/j.drudis.2019.01.004 30654055
     [Google Scholar]
  26. HuangY. ZouL. WangJ. JinQ. JiJ. Stimuli‐responsive nanoplatforms for antibacterial applications.Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol.2022143e177510.1002/wnan.1775 35142071
     [Google Scholar]
  27. DingX. WangA. TongW. XuF.J. Biodegradable antibacterial polymeric nanosystems: A new hope to cope with multidrug‐resistant bacteria.Small20191520190099910.1002/smll.201900999 30957927
     [Google Scholar]
  28. DizajS.M. KouhsoltaniM. PourrezaK. SharifiS. AbdolahiniaE.D. Preparation, characterization, and evaluation of the anticancer effect of mesoporous silica nanoparticles containing rutin and curcumin.Pharm. Nanotechnol.2024123269275
     [Google Scholar]
  29. MemarM.Y. Dalir AbdolahiniaE. YekaniM. KouhsoltaniM. SharifiS. Maleki DizajS. Preparation of rutin-loaded mesoporous silica nanoparticles and evaluation of its physicochemical, anticancer, and antibacterial properties.Mol. Biol. Rep.202350120321310.1007/s11033‑022‑07953‑6 36319783
     [Google Scholar]
  30. ShirmohammadiA. Maleki DizajS. SharifiS. Promising Antimicrobial Action of Sustained Released Curcumin-Loaded Silica Nanoparticles against Clinically Isolated Porphyromonas gingivalis.Diseases20231114810.3390/diseases11010048 36975597
     [Google Scholar]
  31. SharifiS. Dalir AbdolahiniaE. GhavimiM.A. Effect of curcumin-loaded mesoporous silica nanoparticles on the head and neck cancer cell line, HN5.Curr. Issues Mol. Biol.202244115247525910.3390/cimb44110357 36354669
     [Google Scholar]
  32. Clinical and Laboratory Standards Institute.Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically.2018Available From: https://clsi.org/media/1928/m07ed11_sample.pdf
    [Google Scholar]
  33. SamieiM. FarjamiA. DizajS.M. LotfipourF. Nanoparticles for antimicrobial purposes in Endodontics: A systematic review of in vitro studies.Mater. Sci. Eng. C2016581269127810.1016/j.msec.2015.08.070 26478430
     [Google Scholar]
  34. MemarM.Y. YekaniM. SharifiS. DizajS.M. Antibacterial and biofilm inhibitory effects of rutin nanocrystals.Biointerface Res. Appl. Chem.202213213210.33263/BRIAC132.132
     [Google Scholar]
  35. GounaniZ. AsadollahiM.A. PedersenJ.N. Mesoporous silica nanoparticles carrying multiple antibiotics provide enhanced synergistic effect and improved biocompatibility.Colloids Surf. B Biointerfaces201917549850810.1016/j.colsurfb.2018.12.035 30572158
     [Google Scholar]
  36. ChengY. ZhangY. DengW. HuJ. Antibacterial and anticancer activities of asymmetric lollipop-like mesoporous silica nanoparticles loaded with curcumin and gentamicin sulfate.Colloids Surf. B Biointerfaces202018611074410.1016/j.colsurfb.2019.110744 31874345
     [Google Scholar]
/content/journals/iddt/10.2174/0118715265304913240826065228
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Antibacterial Effect of Co-Loaded Curcumin and Rutin in Mesoporous Silica Nanoparticles Compared to their Loading Alone
Infect. Disord. Drug Targets 25, E18715265304913 (2025); https://doi.org/10.2174/0118715265304913240826065228
/content/journals/iddt/10.2174/0118715265304913240826065228
/content/journals/iddt/10.2174/0118715265304913240826065228
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  • Article Type:     Research Article
Keyword(s): antibacterial; antimicrobial activity; curcumin; mesoporous silica nanoparticles; ROS; Rutin

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