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Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders) - Online First
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Tanshinone IIA Regulates NRF2/NLRP3 Signal Pathway to Restrain Oxidative Stress and Inflammation in Uric Acid-Induced HK-2 Fibrotic Models
Authors: Weiliang Zhang, Jiashu Feng, Ruiqi Liu, Ting Xiang and Xinlin WuAvailable online: 28 October 2024More LessIntroduction This study aims to investigate the function and potential mechanism of Tanshinone IIA in uric acid-induced HK-2 fibrosis models. Materials and Methods An in vitro model of fibrosis was constructed using uric acid stimulation. RT-qPCR and Western blot were used to evaluate the levels of inflammatory cytokines. The detection of ROS and ELISA assay were used to analyze the changes in oxidative stress. Result Read More
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Ketogenic Diet and Endocrine and Metabolic Diseases: A Bibliometric Study and Visualization Analysis
Authors: Xinwei Zhang, Yanfei Jiang, Tiantian Cai, Zhaowei Huang, Yuqing Wu and Jinan ZhangAvailable online: 28 October 2024More LessBackground The ketogenic diet, known for its high-fat, low-carbohydrate composition, has been extensively studied in endocrine and metabolic diseases. This study carried out bibliometric analysis to examine the research trends in this field over the past 20 years, aiming to provide insights for future studies. Methods We searched the Web of Science Core Collection for all relevant papers. VOSviewer was used for network vis Read More
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Safety Profile of Statins for Post-Marketing Adverse Cardiovascular Events: A Real-World Pharmacovigilance Analysis
Authors: Jing Li, Junjie Gong, Ziyu Liu, Yuheng Liu, Anqi He and Zengguang WangAvailable online: 28 October 2024More LessAims and objectives The purpose of this study was to comprehensively evaluate the association of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) with neurological adverse events using the US Food and Drug Administration Adverse Event Reporting System (FAERS) database, with the aim of guiding the rational use of statins. Methods The number and clinical characteristics of adverse events Read More
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Effects of ethanol extract from senna leaf (EESL) on inflammation and oxidative stress in mice: A non-targeted metabolomic study
Authors: Xiaoli Huang, Wen Sun, Chang Sun, Jiajun Tan, Liang Wu and Fumeng YangAvailable online: 24 October 2024More LessBackground Senna leaf is a commonly used medication for treating constipation, and long-term use can cause damage to the intestinal mucosa and lead to drug dependence. But the exact mechanism remains unclear. Objective Using non-targeted metabolomics technology to study the mechanism of senna leaf ethanol extract (EESL) inducing inflammation and oxidative stress in mice and causing side effects. Methods E Read More
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Bulky Isolated Adrenal Metastasis as First Presentation of Occult Hepatocellular Carcinoma (HCC) in a Patient with a Synchronous Squamous Carcinoma of the Tongue
Authors: Marco Lodin, Alberto Ragni, Valerio Renzelli, Maura Rossi, Elena Silvia Traverso and Marco GalloAvailable online: 10 October 2024More LessBackground The diagnostic workup of an adrenal mass should always rule out the possibility of an adrenal metastasis, especially in a patient followed-up for a known primitive cancer. Sometimes, however, the incidental finding of a bulky lesion in a cancer patient can lead to the unexpected diagnosis of metastasis from a second occult cancer. Here, we report the case of a voluminous, isolated left adrenal metast Read More
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Correlation Analysis of Traditional Chinese Medicine Constitution and Metabolic Indexes in General Physical Examination People
Authors: Xue Qu, Hua-zhong Xiong, Dong-qi Qu, Hang Liu, Xiao-xuan Xu, Rui Sun and Yang-yang LiuAvailable online: 03 October 2024More LessObjective Analysis of Traditional Chinese Medicine (TCM) constitution type general medical patients and the relationship between the metabolic index. Methods A cohort of 1,029 general individuals who underwent a physical examination at the Affiliated Hospital of Changchun University of Chinese Medicine for identification of their TCM constitution between January 2021 and April 2023 were included in this study. Their data Read More
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Exploration of the Relationship between Polycystic Ovary Syndrome and Recurrent Pregnancy Loss Based on Bioinformatics
Authors: Yuanyuan Wu, Linyu Qin, Guozhen He, Zhijuan Luo and Songping LuoAvailable online: 03 October 2024More LessBackground Recurrent Pregnancy Loss (RPL) and Polycystic Ovary Syndrome (PCOS) are both common diseases involving women of childbearing age, and their pathogenesis is still not sufficiently known. Objective This study aimed to explore the relationship between RPL and PCOS in bioinformatics. Methods Two expression chips, GSE86241 (obtained from 8 PCOS patients and 9 healthy controls) and GSE73025 (obtain Read More
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