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Volume 25, Issue 6
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873

Abstract

Background

Obesity is becoming a global pandemic with pandemic proportions. According to the WHO estimates, there were over 1.9 billion overweight individuals and over 650 million obese adults in the globe in 2016. In recent years, scientists have encountered difficulties in choosing acceptable animal models, leading to a multitude of contradicting aspects and incorrect outcomes. This review comprehensively evaluates different screening models of obesity and obesity-associated comorbidities to reveal the advantages and disadvantages/limitations of each model while also mentioning the time duration each model requires to induce obesity.

Methods

For this review, the authors have gone through a vast number of article sources from different scientific databases, such as Google Scholar, Web of Science, Medline, and PubMed.

Results

models used to represent a variety of obesity-inducing processes, such as diet-induced, drug-induced, surgical, chemical, stress-induced, and genetic models, are discussed. Animal cell models are examined with an emphasis on their use in understanding the molecular causes of obesity, for which we discussed in depth the important cell lines, including 3T3-L1, OP9, 3T3-F442A, and C3H10T1/2. Screening models of obesity-associated co-morbidities like diabetes, asthma, cardiovascular disorders, cancer, and polycystic ovarian syndrome (PCOS) were discussed, which provided light on the complex interactions between obesity and numerous health problems.

Conclusion

Mimicking obesity in an animal model reflects multifactorial aspects is a matter of challenge. Future studies could address the ethical issues surrounding the use of animals in obesity research as well as investigate newly developed models, such as non-mammalian models. In conclusion, improving our knowledge and management of obesity and related health problems will require ongoing assessment and improvement of study models.

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/content/journals/emiddt/10.2174/0118715303312932240801073903
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A Review on In-vivo and In-vitro Models of Obesity and Obesity-Associated Co-Morbidities
Endocr Metab Immune Disord Drug Targets 25, 458 (2025); https://doi.org/10.2174/0118715303312932240801073903
/content/journals/emiddt/10.2174/0118715303312932240801073903
/content/journals/emiddt/10.2174/0118715303312932240801073903
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  • Article Type:     Review Article
Keyword(s): animal model; cell line; health problems; HFD model; Obesity; screening models

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