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Volume 24, Issue 15
  • ISSN: 1871-5303
  • E-ISSN: 2212-3873

Abstract

Although the Mediterranean Diet (MedDiet) may appear simple and locally inspired based on the provided definitions, mounting evidence reveals that adopting a dietary pattern aligned with MedDiet principles can yield numerous health benefits. Also, the MedDiet stands as the gold standard in preventive medicine, so it is not a simplistic diet centered around specific ingredients or cooking methods; instead, it emerges from a distinctive way of life (lifestyle) inherent to the Mediterranean region. This lifestyle encapsulates essential components of a balanced diet and life, including frugality and moderation in food consumption, the utilization of seasonal and traditional products, a focus on locally sourced, eco-friendly, and biodiverse items, personal engagement in culinary preparation, the emphasis on conviviality and social activities during meal consumption, regular engagement in physical activity, adequate hydration, and sufficient rest. In this review, we will establish the interconnections and links between the various aspects of the Mediterranean diet, how these pillars reflect the Mediterranean region's distinctive lifestyle, and how each element is a necessary part of the others. Finally, the seamless integration of social involvement, sufficient rest, regular physical exercise, and diet will be explored to provide a holistic view of the Mediterranean lifestyle and its inherent harmony.

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2024-11-16

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References

  1. UNESCOMediterranean diet,Available from: https://ich.unesco.org/en/RL/mediterranean-diet-00884 2013
  2. FerréG.M. WillettW.C. The mediterranean diet and health: A comprehensive overview.J. Intern. Med.2021290354956610.1111/joim.13333 34423871
     [Google Scholar]
  3. GalbeteC. SchwingshacklL. SchwedhelmC. BoeingH. SchulzeM.B. Evaluating mediterranean diet and risk of chronic disease in cohort studies: An umbrella review of meta-analyses.Eur. J. Epidemiol.2018331090993110.1007/s10654‑018‑0427‑3 30030684
     [Google Scholar]
  4. SofiF. MacchiC. AbbateR. GensiniG.F. CasiniA. Mediterranean diet and health status: An updated meta-analysis and a proposal for a literature-based adherence score.Public Health Nutr.201417122769278210.1017/S1368980013003169 24476641
     [Google Scholar]
  5. GrossoG. MarventanoS. YangJ. MicekA. PajakA. ScalfiL. GalvanoF. KalesS.N. A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: Are individual components equal?Crit. Rev. Food Sci. Nutr.201757153218323210.1080/10408398.2015.1107021 26528631
     [Google Scholar]
  6. FungT.T. RexrodeK.M. MantzorosC.S. MansonJ.E. WillettW.C. HuF.B. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women.Circulation200911981093110010.1161/CIRCULATIONAHA.108.816736 19221219
     [Google Scholar]
  7. SalvadóS.J. BullóM. EstruchR. RosE. CovasM.I. JuradoI.N. CorellaD. ArósF. GraciaG.E. GutiérrezR.V. RomagueraD. LapetraJ. RaventósL.R.M. MajemS.L. PintóX. BasoraJ. MuñozM.A. SorlíJ.V. GonzálezM.M.A. Prevention of diabetes with Mediterranean diets: A subgroup analysis of a randomized trial.Ann. Intern. Med.2014160111010.7326/M13‑1725 24573661
     [Google Scholar]
  8. KastoriniC.M. MilionisH.J. EspositoK. GiuglianoD. GoudevenosJ.A. PanagiotakosD.B. The effect of mediterranean diet on metabolic syndrome and its components: A meta-analysis of 50 studies and 534,906 individuals.J. Am. Coll. Cardiol.201157111299131310.1016/j.jacc.2010.09.073 21392646
     [Google Scholar]
  9. PanagiotakosD.B. PitsavosC. ChrysohoouC. StefanadisC. The epidemiology of type 2 diabetes mellitus in Greek adults: The ATTICA study.Diabet. Med.200522111581158810.1111/j.1464‑5491.2005.01731.x 16241925
     [Google Scholar]
  10. ListaD.J. DiazA.J.F. PeñaT.J.D. NavarroQ.G.M. FuentesF. RiosG.A. MoralesO.A.M. RequeroG.A.I. CaballeroP.A.I. SerranoY.E.M. ZuñigaR.O.A. CamargoA. CantalejoR.F. SeguraL.F. BadimonL. OrdovasJ.M. JimenezP.F. MartinezP.P. MirandaL.J. DiazA.J.F. PeñaA.Y. ArandaE. de LarrivaA.A.P. BadimonL. BadimonJ.J. MolinaB.A. RojoB.R. MuñozB.J. VillarrasoC.J. CamargoA. ChicaJ. CorinaA. GarciaC.J. TenoC.C. CodinaD.A. de TeresaG.E. CasadoD.N. ListaD.J. EstruchR. FernandezJ.M. GandaraF.C. JimenezF.F. PachecoF.G.C.S. RiosG.A. DelgadoG.F. GarduñoG.A. LunaG.P. LunaG.M.J. GuardiaG.L. RequeroG.A.I. MariscalG.F.M. MariscalH.C.M. LucenaJ.R. MoralesJ.A.I. AcuñaL.A. MirandaL.J. SeguraL.F. HinojosaM.C. AlvarezM.M.E. LunaM.D. GarridoM.M.N. CarvajalM.I. Navarro-MartosV. OchoaJ.J. OrdovasJ.M. MinuesaO.J.A. MoralesO.A.M. PanM. OrihuelaP.P. CaballeroP.A.I. CorralP.I. JimenezP.F. MartinezP.P. SunyerP.F.X. NavarroQ.G.M. LaraR.I. ZuñigaR.O.A. ArtalejoR.F. CantalejoR.F. RomeroM.A. RamosR.I. RuizR.J.A. de CastroviejoR.J. VillegasS.P. de LezoS.J. de LezoS.J. PeñaT.J.D. DelgadoV.C. ValverdeR. VisioliF. SerranoY.E.M. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): A randomised controlled trial.Lancet2022399103381876188510.1016/S0140‑6736(22)00122‑2 35525255
     [Google Scholar]
  11. ToledoE. SalvadóS.J. VargasD.C. CosialesB.P. EstruchR. RosE. CorellaD. FitóM. HuF.B. ArósF. GraciaG.E. RomagueraD. CalvoO.M. MajemS.L. PintóX. SchröderH. BasoraJ. SorlíJ.V. BullóM. MirS.M. GonzálezM.M.A. Mediterranean diet and invasive breast cancer risk among women at high cardiovascular risk in the PREDIMED trial: A randomized clinical trial.JAMA Intern. Med.2015175111752176010.1001/jamainternmed.2015.4838 26365989
     [Google Scholar]
  12. TuratiF. CarioliG. BraviF. FerraroniM. SerrainoD. MontellaM. GiacosaA. ToffoluttiF. NegriE. LeviF. La VecchiaC. Mediterranean diet and breast cancer risk.Nutrients201810332610.3390/nu10030326 29518016
     [Google Scholar]
  13. SinghB. ParsaikA.K. MielkeM.M. ErwinP.J. KnopmanD.S. PetersenR.C. RobertsR.O. Association of mediterranean diet with mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis.J. Alzheimers Dis.201439227128210.3233/JAD‑130830 24164735
     [Google Scholar]
  14. WuL. SunD. Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies.Sci. Rep.2017714131710.1038/srep41317 28112268
     [Google Scholar]
  15. ChenX. MaguireB. BrodatyH. O’LearyF. Dietary patterns and cognitive health in older adults: A systematic review.J. Alzheimers Dis.201967258361910.3233/JAD‑180468 30689586
     [Google Scholar]
  16. NavarroE. FuntikovaA.N. FítoM. SchröderH. Can metabolically healthy obesity be explained by diet, genetics, and inflammation?Mol. Nutr. Food Res.2015591759310.1002/mnfr.201400521 25418549
     [Google Scholar]
  17. SerinoA. SalazarG. Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease.Nutrients20181115310.3390/nu11010053 30597847
     [Google Scholar]
  18. RimbauT.A. RimmE.B. RemónM.A. GonzálezM.A. de la TorreR. CorellaD. SalvadóS.J. GraciaG.E. LapetraJ. ArósF. FiolM. RosE. MajemS.L. PintóX. SaezG.T. BasoraJ. SorlíJ.V. MartínezJ.A. VinyolesE. GutiérrezR.V. EstruchR. RaventósL.R.M. Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study.Nutr. Metab. Cardiovasc. Dis.201424663964710.1016/j.numecd.2013.12.014 24552647
     [Google Scholar]
  19. BarqueroC.S. RaventósL.R. DoménechM. EstruchR. Relationship between Mediterranean dietary polyphenol intake and obesity.Nutrients20181010152310.3390/nu10101523 30336572
     [Google Scholar]
  20. ZelichaH. KlotingN. KaplanA. MeirY.A. RinottE. TsabanG. ChassidimY. BluherM. CeglarekU. IsermannB. StumvollM. QuaysonR.N. von BergenM. EngelmannB. Rolle-KampczykU.E. HaangeS.B. TuohyK.M. DiotalleviC. ShelefI. HuF.B. StampferM.J. ShaiI. The effect of high-polyphenol mediterranean diet on visceral adiposity: The DIRECT PLUS randomized controlled trial.BMC Med.202220132710.1186/s12916‑022‑02525‑8 36175997
     [Google Scholar]
  21. NaniA. MurtazaB. KhanS.A. KhanN.A. HichamiA. Antioxidant and anti-inflammatory potential of polyphenols contained in Mediterranean diet in obesity: Molecular mechanisms.Molecules202126498510.3390/molecules26040985 33673390
     [Google Scholar]
  22. MarranzanoM. RayS. GodosJ. GalvanoF. Association between dietary flavonoids intake and obesity in a cohort of adults living in the Mediterranean area.Int. J. Food Sci. Nutr.20186981020102910.1080/09637486.2018.1452900 29575952
     [Google Scholar]
  23. ChuangC.C. ShenW. ChenH. XieG. JiaW. ChungS. McIntoshM.K. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice.J. Agric. Food Chem.20126051124581246810.1021/jf3028107 23210691
     [Google Scholar]
  24. MartinoH.S.D. DiasM.M.S. NorattoG. TalcottS. TalcottM.S.U. Anti-lipidaemic and anti-inflammatory effect of açai (Euterpe oleracea Martius) polyphenols on 3T3-L1 adipocytes.J. Funct. Foods20162343244310.1016/j.jff.2016.02.037
     [Google Scholar]
  25. Kawser HossainM. Abdal DayemA. HanJ. YinY. KimK. SahaK.S. YangG.M. ChoiH. ChoS.G. Molecular mechanisms of the anti-obesity and anti-diabetic properties of flavonoids.Int. J. Mol. Sci.201617456910.3390/ijms17040569 27092490
     [Google Scholar]
  26. SongD. ChengL. ZhangX. WuZ. ZhengX. The modulatory effect and the mechanism of flavonoids on obesity.J. Food Biochem.2019438e1295410.1111/jfbc.12954 31368555
     [Google Scholar]
  27. ParkD.W. BaekK. KimJ.R. LeeJ.J. RyuS.H. ChinB.R. BaekS.H. Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1.Exp. Mol. Med.200941317117910.3858/emm.2009.41.3.020 19293636
     [Google Scholar]
  28. SebaiH. SaniM. YacoubiM.T. AouaniE. BoughanmiG.N. AttiaB.M. Resveratrol, a red wine polyphenol, attenuates lipopolysaccharide-induced oxidative stress in rat liver.Ecotoxicol. Environ. Saf.20107351078108310.1016/j.ecoenv.2009.12.031 20089305
     [Google Scholar]
  29. De GrooteD. Van BelleghemK. DevièreJ. Van BrusselW. MukanezaA. AmininejadL. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects.Ann. Nutr. Metab.2012611152410.1159/000338634 22776850
     [Google Scholar]
  30. BukhariS.N.A. Dietary polyphenols as therapeutic intervention for Alzheimer’s disease: A mechanistic insight.Antioxidants202211355410.3390/antiox11030554 35326204
     [Google Scholar]
  31. FrancoG.A. InterdonatoL. CordaroM. CuzzocreaS. Di PaolaR. Bioactive compounds of the mediterranean diet as nutritional support to fight neurodegenerative disease.Int. J. Mol. Sci.2023248731810.3390/ijms24087318 37108480
     [Google Scholar]
  32. KobyłeckaG.I. SzpakowskiP. KrólA. WiniarekK.D. KobyłeckiA. GłąbińskiA. NowakD. Polyphenols and their impact on the prevention of neurodegenerative diseases and development.Nutrients20231515345410.3390/nu15153454 37571391
     [Google Scholar]
  33. KulkarniS.K. BhutaniM.K. BishnoiM. Antidepressant activity of curcumin: involvement of serotonin and dopamine system.Psychopharmacology2008201343544210.1007/s00213‑008‑1300‑y 18766332
     [Google Scholar]
  34. GonzalezM.M.A. CalvoM.N. Mediterranean diet and life expectancy; beyond olive oil, fruits, and vegetables.Curr. Opin. Clin. Nutr. Metab. Care201619640140710.1097/MCO.0000000000000316 27552476
     [Google Scholar]
  35. MoralesJ.M. BlascoM.M. Presence and strategic use of the Mediterranean Diet in food marketing: Analysis and association of nutritional values and advertising claims from 2011 to 2020.NFS J.2021241610.1016/j.nfs.2021.04.003
     [Google Scholar]
  36. TartibianB. Relationship between the level of physical activity and nutritional status with fatigue in elderly residents of rest homes in Tehran.NAEP201912155168
     [Google Scholar]
  37. KushkestaniM. ParvaniM. MoghadassiM. Malnutrition is associated with cognitive function, tiredness and sleep quality in elderly living nursing home.J. Aging Sci.20208318
     [Google Scholar]
  38. KushkestaniM. ParvaniM. GhafariM. AvazpoorZ. The role of exercise and physical activity on aging-related diseases and geriatric syndromes. SPORT TK -Euro-Amer.J. Sports Sci.2022116610.6018/sportk.464401
     [Google Scholar]
  39. KushkestaniM. The relationship between the level of physical activity and dementia in elderly residents of nursing homes in Tehran.Biomed. J. Sci. Tech. Res.20202932910.26717/BJSTR.2020.29.004800
     [Google Scholar]
  40. KushkestaniM. ParvaniM. BaradaranR. RezaeiA. PourhamzehH. Impact of exercise on fall and its consequences among elderly people.Elder. Health J.202391445410.18502/ehj.v9i1.13109
     [Google Scholar]
  41. KushkestaniM. ParvaniM. NosraniS.E. RezaeiS. The physical activity and fall risk among Iranian older male adults.Open Nurs. J.202014115916710.2174/1874434602014010159
     [Google Scholar]
  42. KushkestanM. The physical activity and fall risk among Iranian older male adults.Open J. Nurs.20201411610.37897/LMRR.2023.1.6
     [Google Scholar]
  43. KushkestaniM. MoghadassiM. ParvaniM. NosraniS.E. RezaeiS. Physical activity as a preventive factor to aging-related physical dysfunction in iranian community-dwelling elderly.J. Aging Sci.20208236
     [Google Scholar]
  44. PadilhaC.S. KushkestaniM. BaptistaL.P. KrügerK. LiraF.S. Autophagy of naïve CD4 + T cells in aging – the role of body adiposity and physical fitness.Expert Rev. Mol. Med.202325e910.1017/erm.2023.2 36655333
     [Google Scholar]
  45. KushkestaniM. Investigation of life expectancy in community-dwelling elderly men in iran and its related factors.J. Aging Sci.202084110
     [Google Scholar]
  46. MajemS.L. RastrolloB.M. ViñasR.B. PfrimerK. VillegasS.A. GonzálezM.M.A. Dietary patterns and nutritional adequacy in a Mediterranean country.Br. J. Nutr.2009101S2212810.1017/S0007114509990559 19594961
     [Google Scholar]
  47. Bach-FaigA. BerryE.M. LaironD. ReguantJ. TrichopoulouA. DerniniS. MedinaF.X. BattinoM. BelahsenR. MirandaG. MajemS.L. Mediterranean diet pyramid today. Science and cultural updates.Public Health Nutr.20111412A2274228410.1017/S1368980011002515 22166184
     [Google Scholar]
  48. SizerF. WhitneyE. PichéL. Nutrition concepts and controversiesAvailable from: https://www.amazon.com/Nutrition-Concepts-Controversies-Frances-Sizer/dp/1337906379 2000
  49. Healthful and sustainable food.Available from: https://sustainable.harvard.edu/our-plan/how-we-operate/food/ 2019
  50. De GarineI. De GarineV. Anthropology of food: between nature and culture. Food and CultureMinutes of the International Congress1998
     [Google Scholar]
  51. GussowJ.D. Mediterranean diets: Are they environmentally responsible?Am. J. Clin. Nutr.19956161383S1389S10.1093/ajcn/61.6.1383S 7754992
     [Google Scholar]
  52. JohnsT. SthapitB.R. Biocultural diversity in the sustainability of developing-country food systems.Food Nutr. Bull.200425214315510.1177/156482650402500207 15214260
     [Google Scholar]
  53. van der HorstK. FerrageA. RytzA. Involving children in meal preparation. Effects on food intake.Appetite201479182410.1016/j.appet.2014.03.030 24709485
     [Google Scholar]
  54. WolfsonJ.A. BleichS.N. SmithK.C. FrattaroliS. What does cooking mean to you?: Perceptions of cooking and factors related to cooking behavior.Appetite20169714615410.1016/j.appet.2015.11.030 26654888
     [Google Scholar]
  55. DiolintziA. PanagiotakosD.B. SidossisL.S. From Mediterranean diet to Mediterranean lifestyle: A narrative review.Public Health Nutr.201922142703271310.1017/S1368980019000612 31156076
     [Google Scholar]
  56. MedinaF.X. Food, diet and eating behaviors in the Mediterranean context. Mediterranean food: history, culture, nutrition.Icaria1996
     [Google Scholar]
  57. BlundellS. Women in ancient Greece.Harvard University Press1995
     [Google Scholar]
  58. CassonL. Everyday life in ancient Rome.Baltimore, MarylandJHU Press1998
     [Google Scholar]
  59. ErmanA. Life in ancient Egypt.Courier Corporation1971
     [Google Scholar]
  60. GlotzG. Ancient Greece at Work: An Economic History of Greece from the Homeric Period to the Roman Conquest.Literary Licensing, LLC1926
     [Google Scholar]
  61. GarlandR. Daily Life in Ancient Greece.Westport2009
     [Google Scholar]
  62. NissinL. Roman sleep: Sleeping areas and sleeping arrangements in the Roman house.,University of Helsinki Open Repository2016
     [Google Scholar]
  63. Graves-BrownC. Dancing for Hathor: women in ancient Egypt.A&C Black2010
     [Google Scholar]
  64. HarveyB.K. Daily life in ancient Rome: A sourcebook.Hackett Publishing2016
     [Google Scholar]
  65. CarcopinoJ. Daily life in Ancient Rome: the people and the city at the height of the Empire.Ringwood, Victoria, AustraliaPenguin Books1956
     [Google Scholar]
  66. PesG.M. DoreM.P. ErrigoA. PoulainM. Analysis of physical activity among free–living nonagenarians from a Sardinian longevous population.J. Aging Phys. Act.201826225425810.1123/japa.2017‑0088 28714795
     [Google Scholar]
  67. PesG.M. ToluF. PoulainM. ErrigoA. MasalaS. PietrobelliA. BattistiniN.C. MaioliM. Lifestyle and nutrition related to male longevity in Sardinia: An ecological study.Nutr. Metab. Cardiovasc. Dis.201323321221910.1016/j.numecd.2011.05.004 21958760
     [Google Scholar]
  68. Montero-SandiegoE. CascalesF.R. RobledilloR.N. LópezC.B. BrunoA.C. BlázquezA.N. Assessment strategies to evaluate the mediterranean lifestyle: A systematic review.Nutrients20221419417910.3390/nu14194179 36235832
     [Google Scholar]
  69. ThuillierJ.P. Athletic exercises in ancient Rome. When Julius Caesar went swimming.Eur. Rev.200412341542610.1017/S1062798704000353
     [Google Scholar]
  70. MurrayS.C. Sport and education in ancient Greece and Rome. A Companion to Ancient Education.Wiley201510.1002/9781119023913.ch29
     [Google Scholar]
  71. DeckerW. Sports and games of ancient Egypt.Yale University Press199210.2307/j.ctt211qv81
     [Google Scholar]
  72. LattimerR.B. Greek athletic sports and festivals - greek athletic sports and festivals. By E. Norman Gardiner, I vol. 8″ × 5″. Pp. xxiv + 533. Illustrations, 190 in text. London: Macmillan and Co., 1910. 10s. 6d.Classical Rev.1911252596010.1017/S0009840X00046278
     [Google Scholar]
  73. HargreavesJ. Sport, power and culture. A social and historical analysis of popular sports in Britain.Blackwell, OxfordPolity Press1986
     [Google Scholar]
  74. LegrandR. NuemiG. PoulainM. ManckoundiaP. Description of lifestyle, including social life, diet and physical activity, of people≥ 90 years living in Ikaria, a longevity blue zone.Int. J. Environ. Res. Public Health20211812660210.3390/ijerph18126602 34205297
     [Google Scholar]
  75. HerbertC. HouseM. DietzmanR. ClimsteinM. FurnessJ. Kemp-SmithK. Blue Zones: Centenarian modes of physical activity: A scoping review.J. Popul. Ageing202213710.1007/s12062‑022‑09396‑0
     [Google Scholar]
  76. AsaadT. Sleep in ancient Egypt. A Companion to Ancient Education.John Wiley & Sons, Inc.201510.1007/978‑1‑4939‑2089‑1_2
     [Google Scholar]
  77. PanagiotakosD.B. Sociodemographic and lifestyle statistics of oldest old people (>80 years) living in ikaria island: The ikaria study.Cardiol. Res. Pract.20112011679187
     [Google Scholar]
  78. GeorgousopoulouE.N. MellorD.D. NaumovskiN. PolychronopoulosE. TyrovolasS. PiscopoS. ValacchiG. AnastasiouF. ZeimbekisA. BountzioukaV. GotsisE. MetallinosG. TyrovolaD. FoscolouA. TurJ.A. MatalasA.L. LionisC. SidossisL. PanagiotakosD. Mediterranean lifestyle and cardiovascular disease prevention.Cardiovasc. Diagn. Ther.2017671394710.21037/cdt.2017.03.11 28529921
     [Google Scholar]
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  • Article Type:     Review Article
Keyword(s): diet; exercise; lifestyle; longevity; Mediterranean; sleep; socialization

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