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- Volume 14, Issue 2, 2024
Drug Delivery Letters - Volume 14, Issue 2, 2024
Volume 14, Issue 2, 2024
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Hot Melt Extrusion Technique for Developing Pharmaceutical Co-crystals: A Review
Authors: Ritu Rathi, Sanshita and Inderbir SinghBackground: In the era of pharmaceutical research and development, the most challenging aspect is to enhance the physicochemical properties of drugs. Hot Melt Extrusion (HME) is a solvent-free, one-step, continuous, scalable, and industrially feasible method for developing pharmaceutical co-crystals. Co-crystallization, as a technique, has gained significant attention for its potential to modify various physicochemical properties Read More
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Current Drug Delivery Strategies to Design Orally Dissolving Formulations to Target Tuberculosis: A Futuristic Review
All the standard anti-tubercular drugs, well established as standard therapy, are preferentially available in formulations compliant with the young adult population. However, their use in the paediatric and geriatric populations is confronted with issues, such as a high likelihood of incorrect dose administration due to practices like dosage form fracture and splitting. This may lead to drug resistance due to misuse and in-accurate d Read More
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Revolutionizing Nitrofurantoin Delivery: Unraveling Challenges and Pioneering Solutions for Enhanced Efficacy in UTI Treatment
Authors: Gouri P. Nanda, Mrunali Patel and Rashmin B. PatelNitrofurantoin is an antimicrobial drug, highly effective in the treatment of critical or chronic bacterial infections of the urinary tract, and hence, it is the first line choice of drug for the treatment of urinary tract infections (UTI). Although the molecule is legacy in nature, there are many challenges in terms of drug product formulation and efficacy thereof. The authors are mainly focused in this literature review on, but not limited to, Read More
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In-vitro and In-silico Examinations on Baicalein-loaded Solid Lipid Nanoparticles for Neurodegeneration
Authors: Mansi Varshney, Bhavna Kumar, Poorvi Varshney, Diwya Kumar Lal and Neeraj Kumar SethiyaBackground: In the current scenario, most of the population affected by neurogenerative disorders like Alzheimer's, Parkinson's, Huntington's, etc., exist among the 10% population 65 years of age group. Neurodegenerative diseases are characterised as chronic and progressive disorders that occur due to the degeneration of neurons. Baicalein is a flavonoid glycoside derived from the roots of Scutellaria baicalensis. Earlier res Read More
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D-Optimal Mixture Design Enabled Development of Lyophilized Nanoemulsifying Drug Delivery System of Paliperidone
Background: Schizophrenia is a chronic disease with acute psychotic symptoms, which is having frequent recurrence. Paliperidone palmitate (PP) is a second-generation antipsychotic drug to treat schizophrenia. Aims: The aim of the study was to prepare lyophilized nanoemulsifying drug delivery system (NEDDS) of paliperidone (PD). Objectives: The primary objective of the current research work was to develop a lyophilized nanoe Read More
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