Drug Delivery Letters - Volume 13, Issue 3, 2023

This review aims to provide historical, present, and future drug deliveries for treating inner ear disorders. Systemic delivery, such as antibiotics and steroids for the inner ear, was the basis on which current drug delivery systems and devices have been researched and developed. Researchers and clinicians had to develop and deliver drugs locally due to adverse effects caused by drugs systemically. Intratympanic method of ant Read More

Background: This study aims to assess the suitability of in vitro drug release methods, dialysis and paddle methods for predicting in vivo behaviour of Aceclofenac (ACE) proniosomes. Methods: ACE proniosomes are prepared using different carriers: glucose, maltodextrin and mannitol by the slurry method. The release studies of ACE proniosomes formulations were performed using the paddle, and dialysis methods while in viv Read More

Background: Dexamethasone (DEX) is a glucocorticosteroid used in the treatment of steroid-responsive inflammatory conditions of the eye. The currently marketed formulations pose several issues, like poor drug residence time, resulting in frequent administration of the formulation, making them less effective. Objective: The present study aims to provide comprehensive data encompassing the designing, optimization, develo Read More

Background: Cinacalcet hydrochloride (CINH) is a BCS class IV drug. It is mainly used for the treatment of chronic renal disease and parathyroid cancer. It exhibits poor oral bioavailability of less than 25%. Objectives: The main objective is to improve the bioavailability of CINH by formulating the nanostructure lipid carrier (NLC). Methods: In this research, glyceryl monostearate (GMS), labrasol, and tween 20 were the main exc Read More

Aim: The goal of this research was to formulate and optimize a cost-effective selfemulsifying drug delivery system (SEDDS) of cilnidipine to increase its dissolution rate. Cilnidipine is a BCS class II active pharmaceutical ingredient, which limits its use. Methods: Cilnidipine's solubility in various oils, surfactants, and cosurfactants, has been investigated. To determine if there is any interaction between cilnidipine and certain excipients, Read More

Background: Anti-sclerostin antibodies are among the most efficient drugs for the treatment of osteoporosis, and have been also expected for the treatment of local bone disorders. We have previously developed porous microparticles of hydroxyapatite and chondroitin sulfate loading anti-sclerostin antibodies formulated with zinc cations. However, the biological behavior and concentration dependence of anti-sclerostin anti Read More