Drug Delivery Letters - Volume 10, Issue 2, 2020

Objective: Drug delivery through the nasal route is emerging as a promising approach due to its capability to transport the drug to the systemic circulation and the central nervous system for therapeutic benefits. Methods: In-situ gelling formulations comprising polymeric substances are emerging as preferential nasal drug delivery systems. When exposed to biological stimuli, they have the ability to undergo a solgel conv Read More

Background: It has been observed that several diseases either acute or chronic have a specific symptom that is emesis. Emesis leads to depletion and removal of several salts and biological essentials required in the body. Domperidone is a D2 receptor antagonist, which triggers the chemoreceptor trigger zone (CTZ) and hence used in the management of nausea and vomiting. Objective: The objective of this project Read More

Background: Paroxetine hydrochloride hemihydrate (PHH) is a serotonin reuptake inhibitor useful for the treatment of diverse psychiatric problems. Existing marketed formulations with frequent administration lead to gastrointestinal (GI) reactions and abrupt fluctuations in plasma level with poor patient compliance. These prerequisites are sufficed by controlled release push-pull osmotic pump tablets (PPOP). Objective: Objective o Read More

Background: The oral administration route is still the most preferred by patients for drug treatment, but is unfortunately not suitable for all drug compounds. For example, protein and peptide drugs (e.g. insulin) are typically administered via injection seeing as they are unstable in the gastrointestinal luminal environment and have poor membrane permeation properties. To overcome this problem, functional excipients Read More

Background: Cancer is one of the leading causes of death. New tactics targeting the survival pathways that provide effective drugs are being developed. Objective: Super paramagnetic nanoparticle serves as drug carrier for drug delivery system. Herein, Iron oxide-CMC-TA and Iron oxide-CMC-GA nanoparticles are synthesized for this target. Methods: Iron oxide (Fe2O3) nanoparticles are synthesized, bound to carboxymet Read More

Aims: The study was aimed to develop mucoadhesive buccal tablets using Aster ericoides leaves mucilage. Background: Mucilages are naturally occurring high-molecular-weight polyuronides, which have been extensively studied for their application in different pharmaceutical dosage forms. Objective: The objective of the present research was to establish the mucilage isolated from the leaves of Aster ericoides as an excipien Read More

Objective: Atorvastatin (ATV) is effective in reducing total cholesterol and low-density lipoprotein levels. Furthermore, it produces pleiotropic effects in neurodegenerative conditions such as Parkinson's, Alzheimer's, and epilepsy. However, due to the effective defense system of the central nervous system (CNS), the development of new medicines for clinical conditions has proven difficult. In this context, nanotechnology wa Read More

Background and Objective: Bacopa monnieri, Evolvulus alsinoides, and Tinospora cordifolia are well known herbal Ayurvedic medicinal plants with a memory enhancing property. The aim of this study was HPTLC analysis for evaluating the effect of ethanolic extract of Bacopa monnieri (BME), Evolvulus alsinoides (EAE) and Tinospora cordifolia (TCE) alone and in combination of equal proportion (CEPs) against scopolamine-induc Read More