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- Volume 16, Issue 5, 2016
Current Topics in Medicinal Chemistry - Volume 16, Issue 5, 2016
Volume 16, Issue 5, 2016
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Formaldehyde as a trigger for protein aggregation and potential target for mitigation of age-related, progressive cognitive impairment
Authors: Tao Su, Woodrow C. Monte, Xintian Hu, Yingge He and Rongqiao HeRecently, formaldehyde (FA), existing in a number of different cells including neural cells, was found to affect age-related cognitive impairment. Oral administration of methanol (the metabolic precursor of FA) triggers formation of senile plaques (SPs) and Tau hyperphosphorylation in the brains of monkeys with memory decline. Intraperitoneal injection of FA leads to hyperphosphorylation of Tau in wild-type mouse brains a Read More
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Targeting Insulin Signaling for the Treatment of Alzheimer's Disease
Authors: Yanxing Chen, Jianfang Zhang, Baorong Zhang and Cheng-Xin GongSporadic Alzheimer's disease (AD) is caused by multiple etiological factors, among which impaired brain insulin signaling and decreased brain glucose metabolism are important metabolic factors. Contrary to previous belief that insulin would not act in the brain, studies in the last three decades have proven important roles of insulin and insulin signaling in various biological functions in the brain. Impaired brain insulin sig Read More
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Energy Metabolism, Adult Neurogenesis and their Possible Roles in Alzheimer’s Disease: A Brief Overview
Authors: Ping Sun, Qian Hua and Angelika G. SchmittAlzheimer’s disease (AD) is the most prevalent human neurodegenerative disease. Disturbances of brain glucose uptake, glucose tolerance, glucose utilization and of the insulin/insulin receptor signaling cascade are thought to be key features of the pathophysiology of AD. Changes in energy homeostasis in the brain and in the periphery dramatically influence the proliferation of adult neural stem cells and neurogenesi Read More
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The Essential Mechanisms of Aging: What Have We Learnt in Ten Years?
By Dazhong YinCarbonylation due to oxidation and glycation is an important biochemical cause of degenerative diseases and aging. While the enigma of aging is understood as a result of molecular dysfunction due to the failure of maintenance systems, a brief history of the interpretation of aging mechanisms and the exact biochemistry connecting entropy and biological aging is addressed. Lipofuscin formation mechanisms resulti Read More
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Ginkgo Biloba for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Guoyan Yang, Yuyi Wang, Jin Sun, Kang Zhang and Jianping LiuBackground: Ginkgo biloba is a natural medicine used for cognitive impairment and Alzheimer’s disease. The objective of this review is to explore the effectiveness and safety of Ginkgo biloba in treating mild cognitive impairment and Alzheimer’s disease. Methods: Electronic search was conducted from PubMed, Cochrane Library, and four major Chinese databases from their inception up to 1st December, 2014 for rando Read More
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Ginseng for Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Yuyi Wang, Guoyan Yang, Juan Gong, Fang Lu, Qingchun Diao, Jin Sun, Kang Zhang, Jinzhou Tian and Jianping LiuBackground: There is no curative treatment for Alzheimer’s disease (AD). Ginseng is widely used in the treatment of AD in Asian countries. Objective: To evaluate the effectiveness and safety of ginseng for AD. Methods: We searched seven main databases for randomized clinical trials (RCTs) on ginseng for AD from their inception to December 2014. The Cochrane risk of bias tool was used to assess the methodological Read More
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Multi-Target Strategy and Experimental Studies of Traditional Chinese Medicine for Alzheimer’s Disease Therapy
Authors: Lin Li, Lan Zhang and Cui-cui YangAlzheimer’s disease (AD) is a multifactorial complex disease. The pathogenesis of AD is very complicated, and involves the β-amyloid (Aβ) cascade, tau hyperphosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, reduced levels of neurotrophic factors, and damage and loss of synapses as well as cholinergic neurons. The multi-target characteristics of traditional Chinese medicine (TCM) may be advantag Read More
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Anti-Alzheimer Therapeutic Drugs Targeting γ-Secretase
Authors: Yan Tan, Qi Zhang, Steven G. Wong and Qian Huaγ-secretase is a membrane-embedded aspartyl protease carrying out cleavage of more than 100 single transmembrane-spanning proteins, including APP, Notch, N-cadherin, etc. Its subunit, presenilin (PS) is the catalytic component, of which mutations are a major cause of early onset familial Alzheimer disease (FAD). These mutations lead to an increase in the production of the highly amyloidogenic Aβ42 isoform. Drugs Read More
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Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an Aβ23-35-Induced Alzheimer’s Disease Rat Model
Authors: Mei-Hua Qu, Xiaoyun Yang, Yuming Wang, Qingjuan Tang, Hailin Han, Jia Wang, Guo- Du Wang, Changhu Xue and Zhiqin GaoBoth Docosahexaenoic acid (DHA) and Phosphatidylcholine (PC) have been shown to halt the pathogenesis of Alzheimer disease (AD) and vascular dementia. This study aimed to investigate the role of DHA-containing PC (DHA-PC) in the improvement of Aβ25-35-induced cognitive deficits in rats. Aβ25-35-induced AD rats were treated for 30 days with DHA-PC, which was extracted from Sthenoteuthis oualaniensis spawns. Cognitive Read More
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Levetiracetam might act as an efficacious drug to attenuate cognitive deficits of Alzheimer’s disease
By Rong XiaoLevetiracetam is a homologue of piracetam with an a-ethyl side-chain substitution and it is a Food and Drug Administration (FDA) approved antiepileptic drug. Recently, several studies have found that levetiracetam was able to reduce seizure frequency in epileptic seizures patients without affecting their cognitive functions. In the present review, the effects of levetiracetam on cognitive improvement were summariz Read More
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Mechanisms of Acupuncture Effect on Alzheimer’s Disease in Animal- Based Researches
Authors: Yan Cao, Li-Wen Zhang, Jian Wang, Si-Qi Du, Ling-Yong Xiao, Jian-Feng Tu and Cun-Zhi LiuAlzheimer’s disease is the most common type of dementia in the aging population worldwide. The etiology and treatment of Alzheimer’s disease are still not very clear. Finding a new treatment is urgent due to the increasing population aging. Acupuncture has been practicing in China for more than 3000 years and reported to be beneficial in treating cognitive impairment of Alzheimer’s disease. This paper reviews the recent de Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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