Current Topics in Medicinal Chemistry - Volume 16, Issue 26, 2016

Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an important place in medicinal chemistry. It is an essential core scaffold present in many natural (Vitamin B1- Thiamine) and synthetic medicinally important compounds. The versatility of thiazole nucleus demonstrated by the fact that it is an essential part of penicillin nucleus and some of its derivatives which have shown antimicrobial (sulf Read More

Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a five membered heterocyclic azole ring is found in naturally occuring ibetonic acid along with some of the marketed drugs such as valdecoxib, flucloxacillin, cloxacillin, dicloxacillin, and danazol. It is also significant for showing antipsychotic acti Read More

The three heteroatoms containing five membered heterocycles such as thiadiazoles have been extensively studied due to their important pharmacological activities. The thiadiazole nucleus is an important class of compounds for new drug development. The chemical and biological behavior and synthesis of thiadiazole derivatives have gained much importance in last few decades. This review article provides up to d Read More

The global tuberculosis epidemic and emergence of drug resistance call for intensive research on new antimycobacterial agents. Recent development is focused mainly on heterocyclic molecules. In many cases, introduction of sulphur has improved antimicrobial activity; many drugs feature a sulphur heterocycle. Thiophene derivatives and thiadiazoles including derived ortho-condensed heterocycles have been found Read More

Benzimidazole is a heterocyclic aromatic organic compound which has been an important pharmacophore and privileged structure in medicinal chemistry. Substituted benzimidazoles have considerable interest as compounds with a wide spectrum of biological activity and low toxicity. Benzimidazole derivatives are structurally related to purine nucleoside bases, which allow them to interact easily with the biopolymers o Read More

The imidazo[1,2-a]pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The pr Read More

The fascinating chemical properties of N-heterocyclic carbene (NHC) complexes showed them to be a suitable class of complexes to be investigated for their applications as drugs in the treatment of the infectious disease or cancer. In particular, the great structural versatility provided a library of compounds with a low cytotoxic profile, suitable candidates as new anticancer agents. Most of these complexes ha Read More