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Volume 24, Issue 22
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Introduction

Toxoplasmosis is a worldwide distributed zoonosis caused by (), an obligate intracellular protozoan. The infection in immunocompetent hosts usually progresses with mild or no symptoms. However, in immunocompromised individuals, this disease can cause severe or fatal symptoms.

Methods

Sulfadiazine and pyrimethamine are two drugs used as standard therapies for human toxoplasmosis. Although they do not cause chronic infection, they may cause hematological toxicity, hypersensitivity, intolerance, teratogenic effects, gastrointestinal disorders, and bone marrow suppression.

Results

The limited effect, significant toxicity, and emerging resistance to current drugs available to treat infections require investigating other effective, nontoxic, and well-tolerated alternatives. Medicinal plants are, traditionally, the most promising sources used to treat infectious diseases.

Conclusion

This review provides data on new therapeutic and prophylactic methods for infection based on the use of extracts and/or compounds derived from natural products, which have been reported to be useful as alternative treatment options in the last 20 years.

© 2024 Bentham Science Publishers
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2025-05-08

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The Search for Drugs Derived from Natural Products for Toxoplasma gondii Infection Treatment in the Last 20 Years - A Systematic Review
Curr. Top. Med. Chem. 24, 1960 (2024); https://doi.org/10.2174/0115680266299409240606062235
/content/journals/ctmc/10.2174/0115680266299409240606062235
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  • Article Type:     Review Article
Keyword(s): Immunocompetent; Phytotherapy; Plant extract; Toxicity; Toxoplasma gondii; Toxoplasmosis

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