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The gut microbiota has been linked to the pathogenesis of stress-related illnesses in a growing number of research. Chronic stress may alter behaviour, cognition, biochemistry, and gut flora. Gut bacteria may impact the brain and body by communicating with the host through the microbiota- gut-brain axis (mostly immunological, neuroendocrine, and neurological pathways). It is thought that taking probiotics might help with persistent stress-induced depression. Lactobacillus helveticus is a commonly used industrial thermophilic starter in manufacturing a variety of cheeses by fermenting milk. An increasing amount of scientific data suggests that strains of L. helveticus exhibit health-promoting qualities and their technical significance. In this review, we summarize the findings of several main literature publications on the capacity of L. helveticus strains to affect human health favourably.