Current Signal Transduction Therapy - Volume 9, Issue 1, 2014

Aims: We investigated whether bortezomib synergizes with arsenious acid in killing promyelocytic leukemia HL-60 cells in vitro and in vivo. Main Methods: Cell culture, MTT assay, Hoechest 33324 staining, flow cytometry assay, determination of DNA fragmentation, immunoblotting analysis, HL60 xenograft mice models and animal experiments. Key Findings: Bortezomib inhibited proliferation of HL-60 cells in a time- and dose Read More

Background: Glioblastoma is the most aggressive and common primary tumor of the central nervous system. Resistance to temozolomide, the first-line chemotherapy for glioblastoma, always leads to treatment failure. Further understanding of the molecular mechanisms of temozolomide resistance in glioblastoma is desperately needed. The purpose of this study was to identify miRNAs correlated with temozolomide treat Read More

Growth factor signaling via receptor tyrosine kinases plays a central role in initiating and maintaining a malignant phenotype. Fibroblast growth factors (FGF) and their receptor family (FGFR1-4) are key players in various human solid and hematological tumors and have been linked to tumor cell proliferation, resistance to chemotherapy and apoptosis, angiogenesis, invasion and metastasis. FGFRs are commonly activated by Read More

Pancreatic cancer is one of the most common human cancers with very low survival rate. So far, the difficulties to make early diagnosis and find curative therapy for this malignant disease remain challenging. Considering Chinese medicine with a long history of clinical application in treating various human diseases, it has been now introduced into the anti-cancer treatment and begun to attract attentions of researchers world Read More

Pioneer works have identified some microRNAs (miRNAs) with oncogenic or tumor-suppressive properties in glioblastoma multiforme (GBM), an aggressive brain tumor with dismal prognosis. Differential expression of these noncoding small RNA in cancers positions them as attractive biomarkers for diagnosis, prognosis and therapeutic decision in GBMs. In addition, abnormal miRNAs provide new interesting therapeutic Read More

Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate Read More

We analyzed the clinicopathological characteristics of 1,425 primary breast cancer patients admitted to the Cancer Hospital of Shantou University Medical College from 1995 to 2008. The peak age group was 45-49 years old and median age was 49 years old. Sixty-two percent of the patients were pre-menopausal, while the remaining was postmenopausal. In the present study, 53% of the patients were in stage I-II of TNM stag Read More

7-Difluoromethyl-5, 4’-dimethoxygenistein (DFMG), prepared by the difluoromethylation and alkylation of Genistein, is a new active chemical entity. In this study, we investigated the inhibitory effect of DFMG on Lysophosphatidyl choline (LPC)-induced apoptosis of human umbilical vein endothelial cells-12 (HUVEC-12) through mitochondrial apoptosis pathway. Lysophosphatidyl choline (LPC) was used to build apoptosis model in HUV Read More