Current Signal Transduction Therapy - Volume 18, Issue 2, 2023

Bilirubin is a yellow tetrapyrrole molecule found in the gastrointestinal system, and it is produced when hemoglobin (Hb) is degraded. For treating various liver disorders like jaundice, serum bilirubin in the body is a testing marker. Jaundice develops when the serum bilirubin level is more significant than 2.0 to 2.5 mg/dl. Examining different forms of bilirubin, i.e., conjugated (direct) bilirubin, unconjugated (indirect) bilirubin, Read More

Background: Probiotics exhibit significant activity in the immune system by activating multiple immune mechanisms. Resveratrol is a non-flavonoid polyphenol. It has various pharmacological effects, including anti-oxidative, anti-inflammatory, anti-proliferative, and anti-angiogenesis effects. Objectives: The present study investigates the potential immunomodulatory and antitumor activity of the combination treatment of prob Read More

According to the latest data, the cancer prevalence fraction has surged to the highest number. This is why cancer has become a prominent disease that must be seen as a serious issue. Inhibitory action and ideas become prominent and necessary because of the rising death incidence daily. The simplifying idea of inhibition of cancer is targeting the complex that forms between the tyrosine kinase and ATP, which ultimately provid Read More

Introduction: Janus kinase 2 (JAK2) is an intracellular signaling protein. JAK2 p. V617F is a common variant in normal karyotype myeloproliferative neoplasms (MPN). Highresolution melting (HRM) analysis is one of the essential methods for detecting the JAK2 p.V617F variant. In this study, we have investigated the effect of DNA concentration on detecting the JAK2 p.V617F variant using the HRM method. Methods: Genomic DN Read More

Background: Large datasets are logically common yet frequently difficult to interpret. Principal Component Analysis (PCA) is a technique to reduce the dimensionality of a dataset. Objective: The main objective of this work is to use principal component analysis to interpret and classify phonocardiogram signals. Methods: Finding new factors aids in the reduction of important components of an eigenvalue/ eigenvector pr Read More

Introduction: RET (Rearranged during transcription) kinase is one of the key targets for anticancer drug development. Understanding the real mechanism of pharmacological action is aided by the protein-ligand interaction. The purpose of this study is to find the most effective RET inhibitors. Methods: Firstly, through a literature survey, we understood that tetrazole is useful nuclei to provide anticancer activity. Hence Read More

Background: Deltamethrin is a class II synthetic pyrethroid pesticide extensively used to control pests and vectors in the agriculture sector and health management programme. Due to excessive applications of this pesticide in the environment, it is harming many organisms other than the target organisms. Higher organisms like human beings are also affected by this pesticide because it instigates the impairment of the cen Read More

Background: Bladder cancer is the 9th most prevalent malignancy worldwide. Fibroblast Growth Factor Receptor 3b (FGFR3b), involved in cell proliferation, differentiation, and migration, is a mutations hotspot for bladder cancer with the most prevalent aberration being S249C. Objective: Impact of S249C of FGFR3b on bladder tumorigenesis via immediate downstream adapter proteins, Fibroblast Growth Factor Receptor S Read More