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- Volume 6, Issue 3, 2013
Current Radiopharmaceuticals - Volume 6, Issue 3, 2013
Volume 6, Issue 3, 2013
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New Issues for Copper-64: from Precursor to Innovative Pet Tracers in Clinical Oncology
Authors: Laura Evangelista, Mansi Luigi and Giuseppe Lucio CasciniThe role of copper in the metabolism of human cancer cells has been largely investigated in the last 20 years and a strong relationship between copper levels and cancer progression has been demonstrated. Moreover copper is involved in tumor angiogenesis as well as in non-neoplastic conditions like neurodegenerative diseases. The main mechanism of action is related to a cellular transporter (CTR1) that plays a pivotal Read More
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Gadolinium-Deferasirox-D-Glucosamine: Novel Anti-Tumor and MR Molecular (Theranostic) Imaging Agent
Target and purpose: Cancer and heart disease are hard maladies in human communities. To recognize these kinds of diseases in primary states can help for remission and decreasing the expenses. One of the best techniques for recognizing is imaging of the tissue. Methods: The main reason of this study is to survey the design of molecules Gd3+ - Defrasirox - DG as a type of glucose labeled with gadolinium to capture more spec Read More
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Mixed Tridentate π -Donor and Monodentate π -Acceptor Ligands as Chelating Systems for Rhenium-188 and Technetium-99m Nitrido Radiopharmaceuticals
A new molecular metallic fragment for labeling biologically active molecules with 99mTc and 188Re is described. This system is composed of a combination of tridentate π-donor and monodentate π-acceptor ligands bound to a [M≡ N]2+ group (M = 99mTc, 188Re) in a pseudo square-pyramidal geometry. A simple structural model of the new metallic fragment was obtained by reacting the ligand 2, 2’-iminodiethanethi Read More
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Cellular Toxicity and Apoptosis Studies in Osteocarcinoma Cells, a Comparison of 177Lu-EDTMP and Lu-EDTMP
Authors: Chandan Kumar, Aruna Korde, Kusum V. Kumari, Tapas Das and Grace SamuelObjective: The most promising bone pain palliative agent such as 177Lu-EDTMP emerges as a newer radiopharmaceutical for cancer management. Thus, it was of interest to study the cell uptake of this agent in osteocarcinoma cell line and investigate the underlying mechanism of cellular toxicity. Methods: The cell binding studies of 177Lu-EDTMP were carried out in osteocarcinoma cells (MG63) after induction of bone mine Read More
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Targeted Radionuclide Therapy - An Overview
Authors: Ashutosh Dash, F. F. (Russ) Knapp and M. R.A. PillaiRadionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional external beam therapy, RNT targets diseases at the cellular level rather than on a gross anatomical level. This concept is a blend of a tracer moiety that mediates a site specific accumulation followed by induction of cytotoxicity with the short-r Read More
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