Current Respiratory Medicine Reviews - Volume 20, Issue 1, 2024

Code 35, the cystic fibrosis transmembrane conductance regulator (CFTR) causes respiratory failure, inflammation, and decreased airway mucociliary clearance. The absence of trustworthy preclinical models that replicate the anatomical, immunological, and bioelectrical characteristics of human CF lungs restricts the discovery of new therapies for the disease. Alternative carriers to liposomes, polymeric nanoparticles, a Read More

Background: This study aimed to assess the relationship between COVID-19 severity and the plasma levels of vascular endothelial growth factor. Methods: This cross-sectional study was conducted on 86 patients with COVID-19. A 5 ml venous blood sample was taken on the first day of hospitalization. VEGF was measured with the ELISA method using the Hangzhou East biopharm VEGF ELIZA Kit. Results: The mean age o Read More

Objective: The study aimed to determine the critical gaps in the care of drug-resistant tuberculosis to implement strategies for its elimination. Material and Methods: Cases with various resistance profiles that were presented to the National Advisory Group for Drug Resistance during the years 2019-2022 have been described. Results and Discussion: 104 cases were included in this study. 41% of the patients had diabetes ( Read More

Objective: This study aimed to explore the impact of various COVID-19 vaccines on the menstrual cycle of Jordanian women. Materials and Methods: We conducted a retrospective analysis of tracked menstrual changes using an anonymous questionnaire written in the local language. We received 732 responses, and after exclusions, 617 responses were analyzed. The questionnaire covered six sectors: demographics, med Read More

Introduction: Acute exacerbations of COPD are responsible for 60% of health costs, reduce patients' quality of life, and accelerate disease progression. COPD endotypes are expected to provide new insights about clinical phenotypic variability and therapeutic response between individuals through certain biomarker approaches. Objective: Our study aims to identify the relationship between COPD endotypes and e Read More

Background: Understanding immunoreactivity against SARS-CoV-2 provides a basis for the pathophysiology of COVID-19 while also providing a means to confirm the disease and reduce its transmission. Methods: The present cross-sectional study was conducted from February 1st, 2020 to December 30th, 2022. The patients’ characteristics, clinical and laboratory data, Polymerase Chain Reaction (PCR) results, and the pres Read More

Background: CT findings and Ground glass opacity (GGO) volumes may differ between SARS CoV-2 non-variant, alpha, delta, and omicron variants. Objective: To compare the thoracic CT findings, GGO volumes, and GGOs’ lung uptake rates among patients with COVID-19 variants. Methods: Thoracic CT images of 83 patients with non-variant, 78 patients with alpha variant, 93 patients with delta variant, and 73 patients with o Read More

Background and Objective: Respiratory complications of COVID-19 should be considered as critical concerns that require prompt medical intervention. The aim of this study was to examine the impact of COVID-19 on pulmonary function and quality of life among recovered patients through a three-month follow-up period. Methods: This pilot study aimed to assess the pulmonary functions and quality of life in 32 COVI Read More

Background: Previous studies indicate a close relationship between the severity of COVID-19 and oxidative stress. N-acetyltransferase 2 (NAT2) is an enzyme that metabolizes a wide range of xenobiotics and plays an important role in the regulation of reactive oxygen species, consequently contributing to the development of oxidative stress. Aim: To determine the impact of NAT2 gene variants on the risk of developing and t Read More

Background and Objective: Pulmonary involvement is a common extra-articular manifestation of rheumatoid arthritis (RA). The present study attempts to highlight the extent of involvement by assessing lung function using pulmonary function tests (PFTs) in patients with RA. Methods: This pilot study involved 30 patients with RA and an equal number of age- and sexmatched healthy controls. All the study participants were s Read More

Introduction: Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a peripheral polyneuropathy. Chronic damage to neuronal myelin by the immune system results in inflammation and demyelination of the peripheral nervous system. Several side effects have been reported with Coronavirus disease 2019 (COVID-19) vaccines. There are some reports of vaccineinduced- CIDP. In this study, we described the occurre Read More