Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Reviews in Clinical and Experimental Pharmacology
  4. Fast Track Articles
  5. Fast Track Article
image of Nonopioid Drugs for Postoperative Pain: A Selection Governed by Choices of the Authors of Academic Articles

Abstract

The opioid crisis has profoundly changed the interest in using nonopioid analgesics. This review identified nonopioid drugs receiving the most interest in the treatment of postoperative pain. Publication-based interest, which reflects the authors’ choices of subjects for academic articles, was used to show the shifts in their interest. The authors’ choices of a particular drug for an article’s subject were regarded as reflective of the collective opinion of experts most knowledgeable on the subject. The frequency with which a drug was the topic of an article was measured with the use of specific bibliometric indices. They were employed to select nonopioid drugs for this review. These included acetaminophen, dexmedetomidine, dexamethasone, ketamine, gabapentin, ibuprofen, ketorolac, diclofenac, magnesium sulfate, clonidine, intravenous lidocaine, and meloxicam (in order of most to least bibliometric interest). Individual reviews on these agents described how the bibliometric indices characterized a drug. They also addressed the question of whether a nonopioid analgesic produced a marked opioid-sparing effect. Information relative to this question was presented the results of meta-analyses with emphasis on the possible reduction of opioid-related side effects. Overall, nonopioid drugs demonstrating the largest popularity among authors and continuous interest growth in 2018-2022 include acetaminophen, dexmedetomidine, dexamethasone, and ibuprofen. The relevant meta-analyses show that nonopioids, administered as components of multimodal analgesia, provided the opioid-sparing effect; they also show that the most common change in the opioid-related side effects was a lower incidence of postoperative nausea and vomiting.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/crcep/10.2174/0127724328327509240919102209
2024-10-01
2024-11-26

  • From This Site

    /content/journals/crcep/10.2174/0127724328327509240919102209
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Kharasch E.D. Avram M.J. Clark J.D. Rational perioperative opioid management in the era of the opioid crisis: Reply. Anesthesiology 2020 133 4 942 943 10.1097/ALN.0000000000003497 32773694
    [Google Scholar]
  2. Okie S. A flood of opioids, a rising tide of deaths [published correction appears in N Engl. J. Med. 2010 363 21 1981 1985
    [Google Scholar]
  3. Kehlet H. Dahl J.B. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth. Analg. 1993 77 5 1048 1056 10.1213/00000539‑199311000‑00030 8105724
    [Google Scholar]
  4. Joshi G.P. Rational multimodal analgesia for perioperative pain management. Curr. Pain Headache Rep. 2023 27 8 227 237 10.1007/s11916‑023‑01137‑y 37405552
    [Google Scholar]
  5. Kissin I. Can a bibliometric indicator predict the success of an analgesic? Scientometrics 2011 86 3 785 795 10.1007/s11192‑010‑0320‑7
    [Google Scholar]
  6. Kissin I. Bradley E.L. Jr Top journals selectivity index and “me-too” drugs. Scientometrics 2012 91 1 131 142 10.1007/s11192‑011‑0556‑x
    [Google Scholar]
  7. Vlassakov KV Kissin I Drug Des Devel Ther. 2014;8:2463-2473. Published 2013 2014 Dec 9 10.2147/DDDT.S73862 25525336
    [Google Scholar]
  8. Kissin I. What can big data on academic interest reveal about a drug? Reflections in three major us databases. Trends Pharmacol. Sci. 2018 39 3 248 257 10.1016/j.tips.2017.12.005 29358009
    [Google Scholar]
  9. Kumar K. Kirksey M.A. Duong S. Wu C.L. A review of opioid-sparing modalities in perioperative pain management: Methods to decrease opioid use postoperatively. Anesth. Analg. 2017 125 5 1749 1760 10.1213/ANE.0000000000002497 29049119
    [Google Scholar]
  10. Fiore J. F. Oilek G. El-Kefraoui C. Preventing opioid prescription after major surgery: A scoping review of opioid-free analgesia. Br. J. Anaesth. 2019 123 5 627 636 10.1016/j.bja.2019.08.014
    [Google Scholar]
  11. Shanthanna H. Ladha K.S. Kehlet H. Joshi G.P. Perioperative Opioid Administration. Anesthesiology 2021 134 4 645 659 10.1097/ALN.0000000000003572 32991672
    [Google Scholar]
  12. Hurley R.W. Elkassabany N.M. Wu C.L. Acute postoperative pain. Miller’s Anesthesia 9th ed Elsevier Philadelphia 2020 2614 2638
    [Google Scholar]
  13. Paulozzi L.J. Budnitz D.S. Xi Y. Increasing deaths from opioid analgesics in the United States. Pharmacoepidemiol. Drug Saf. 2006 15 9 618 627 10.1002/pds.1276 16862602
    [Google Scholar]
  14. Grosser T. Smyth E. Fitzgerald G.A. Anti-inflammatory, antipyretic, and analgesic agents. In: Goodman and Gilman’s The Pharmacological Basis of Therapeutics 12 th ed McGrow Hill New York 2011
    [Google Scholar]
  15. Elia N. Lysakowski C. Tramèr M.R. Does multimodal analgesia with acetaminophen, nonsteroidal anti-inflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Anesthesiology 2005 103 6 1296 1304 10.1097/00000542‑200512000‑00025 16306743
    [Google Scholar]
  16. Doleman B. Read D. Lund J.N. Williams J.P. Preventive acetaminophen reduces postoperative opioid consumption, vomiting, and pain scores after surgery. Reg. Anesth. Pain Med. 2015 40 6 706 712 10.1097/AAP.0000000000000311 26469366
    [Google Scholar]
  17. Martinez V. Beloeil H. Marret E. Fletcher D. Ravaud P. Trinquart L. Non-opioid analgesics in adults after major surgery: Systematic review with network meta-analysis of randomized trials. Br. J. Anaesth. 2017 118 1 22 31 10.1093/bja/aew391 28039239
    [Google Scholar]
  18. Guo H. Wang C. He Y. A meta-analysis evaluates the efficacy of intravenous acetaminophen for pain management in knee or hip arthroplasty. J. Orthop. Sci. 2018 23 5 793 800 10.1016/j.jos.2018.04.008 29910098
    [Google Scholar]
  19. Fillingham Y.A. Hannon C.P. Erens G.A. Mullen K. Casambre F. Visvabharathy V. Hamilton W.G. Della Valle C.J. The efficacy and safety of acetaminophen in total joint arthroplasty: Systematic review and direct meta-analysis. J. Arthroplasty 2020 35 10 2715 2729 10.1016/j.arth.2020.05.037 32563592
    [Google Scholar]
  20. Bae S. Alboog A. Esquivel K.S. Abbasi A. Zhou J. Chui J. Efficacy of perioperative pharmacological and regional pain interventions in adult spine surgery: A network meta-analysis and systematic review of randomised controlled trials. Br. J. Anaesth. 2022 128 1 98 117 10.1016/j.bja.2021.08.034 34774296
    [Google Scholar]
  21. Kamibayashi T. Maze M. Weiskopf R.B. Weiskopf R.B. Todd M.M. Clinical uses of alpha2 -adrenergic agonists. Anesthesiology 2000 93 5 1345 1349 10.1097/00000542‑200011000‑00030 11046225
    [Google Scholar]
  22. Weerink M.A.S. Struys M.M.R.F. Hannivoort L.N. Barends C.R.M. Absalom A.R. Colin P. Clinical pharmacokinetics and pharmacodynamics of dexmedetomidine. Clin. Pharmacokinet. 2017 56 8 893 913 10.1007/s40262‑017‑0507‑7 28105598
    [Google Scholar]
  23. Esmaoglu A. Yegenoglu F. Akin A. Turk C.Y. Dexmedetomidine added to levobupivacaine prolongs axillary brachial plexus block. Anesth. Analg. 2010 111 6 1548 1551 10.1213/ANE.0b013e3181fa3095 20889939
    [Google Scholar]
  24. Vorobeichik L. Brull R. Abdallah F.W. Evidence basis for using perineural dexmedetomidine to enhance the quality of brachial plexus nerve blocks: A systematic review and meta-analysis of randomized controlled trials. Br. J. Anaesth. 2017 118 2 167 181 10.1093/bja/aew411 28100520
    [Google Scholar]
  25. Brummett C.M. Hong E.K. Janda A.M. Amodeo F.S. Lydic R. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the duration of analgesia by blocking the hyperpolarization-activated cation current. Anesthesiology 2011 115 4 836 843 10.1097/ALN.0b013e318221fcc9 21666435
    [Google Scholar]
  26. Blaudszun G. Lysakowski C. Elia N. Tramèr M.R. Effect of perioperative systemic α2 agonists on postoperative morphine consumption and pain intensity: Systematic review and meta-analysis of randomized controlled trials. Anesthesiology 2012 116 6 1312 1322 10.1097/ALN.0b013e31825681cb 22546966
    [Google Scholar]
  27. Zhao W. Li J. Wang N. Wang Z. Zhang M. Zhang H. Liu M. He J. Yu D. Effect of dexmedetomidine on postoperative nausea and vomiting in patients under general anaesthesia: An updated meta-analysis of randomised controlled trials. BMJ Open 2023 13 8 e067102 10.1136/bmjopen‑2022‑067102 37527891
    [Google Scholar]
  28. Watcha M.F. White P.F. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992 77 1 162 184 10.1097/00000542‑199207000‑00023 1609990
    [Google Scholar]
  29. Turan A. Sessler D.I. Steroids to ameliorate postoperative pain. Anesthesiology 2011 115 3 457 459 10.1097/ALN.0b013e31822a2871 21792052
    [Google Scholar]
  30. Gan T.J. Meyer T.A. Apfel C.C. Chung F. Davis P.J. Habib A.S. Hooper V.D. Kovac A.L. Kranke P. Myles P. Philip B.K. Samsa G. Sessler D.I. Temo J. Tramèr M.R. Vander Kolk C. Watcha M. Society for Ambulatory Anesthesia Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth. Analg. 2007 105 6 1615 1628 10.1213/01.ane.0000295230.55439.f4 18042859
    [Google Scholar]
  31. Albrecht E. Kern C. Kirkham K.R. A systematic review and meta‐analysis of perineural dexamethasone for peripheral nerve blocks. Anaesthesia 2015 70 1 71 83 10.1111/anae.12823 25123271
    [Google Scholar]
  32. De Oliveira G.S. Jr Almeida M.D. Benzon H.T. McCarthy R.J. Perioperative single dose systemic dexamethasone for postoperative pain: A meta-analysis of randomized controlled trials. Anesthesiology 2011 115 3 575 588 10.1097/ALN.0b013e31822a24c2 21799397
    [Google Scholar]
  33. Waldron N.H. Jones C.A. Gan T.J. Allen T.K. Habib A.S. Impact of perioperative dexamethasone on postoperative analgesia and side-effects: Systematic review and meta-analysis. Br. J. Anaesth. 2013 110 2 191 200 10.1093/bja/aes431 23220857
    [Google Scholar]
  34. Hannon C.P. Fillingham Y.A. Mason J.B. Sterling R.S. Casambre F.D. Verity T.J. Woznica A. Nelson N. Hamilton W.G. Della Valle C.J. The efficacy and safety of corticosteroids in total joint arthroplasty: A direct meta-analysis. J. Arthroplasty 2022 37 10 1898 1905.e7 10.1016/j.arth.2022.03.084 36162922
    [Google Scholar]
  35. Ormseth C.H. LaHue S.C. Oldham M.A. Josephson S.A. Whitaker E. Douglas V.C. Predisposing and precipitating factors associated with delirium. JAMA Netw. Open 2023 6 1 e2249950 10.1001/jamanetworkopen.2022.49950 36607634
    [Google Scholar]
  36. Huizenga N.A.T.M. Koper J.W. de Lange P. Pols H.A.P. Stolk R.P. Grobbee D.E. de Jong F.H. Lamberts S.W.J. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. J. Clin. Endocrinol. Metab. 1998 83 1 47 54 10.1210/jcem.83.1.4498 9435415
    [Google Scholar]
  37. Schmid R.L. Sandler A.N. Katz J. Use and efficacy of low-dose ketamine in the management of acute postoperative pain: A review of current techniques and outcomes. Pain 1999 82 2 111 125 10.1016/S0304‑3959(99)00044‑5 10467917
    [Google Scholar]
  38. Bell R.F. Kalso E.A. Ketamine for pain management. Pain Rep. 2018 3 5 e674 10.1097/PR9.0000000000000674 30534625
    [Google Scholar]
  39. Laskowski K. Stirling A. McKay W.P. Lim H.J. A systematic review of intravenous ketamine for postoperative analgesia. Can. J. Anaesth. 2011 58 10 911 923 10.1007/s12630‑011‑9560‑0 21773855
    [Google Scholar]
  40. Wang L. Johnston B. Kaushal A. Cheng D. Zhu F. Martin J. Ketamine added to morphine or hydromorphone patient-controlled analgesia for acute postoperative pain in adults: A systematic review and meta-analysis of randomized trials. Can. J. Anaesth. 2016 63 3 311 325 10.1007/s12630‑015‑0551‑4 26659198
    [Google Scholar]
  41. Xu B. Wang Y. Zeng C. Analgesic efficacy and safety of ketamine after total knee or hip arthroplasty: a meta-analysis of randomised placebo-controlled studies. BMJ Open 2019 9 9 e028337
    [Google Scholar]
  42. Hurley R.W. Cohen S.P. Williams K.A. Rowlingson A.J. Wu C.L. The analgesic effects of perioperative gabapentin on postoperative pain: A meta-analysis. Reg. Anesth. Pain Med. 2006 31 3 237 247 10.1097/00115550‑200605000‑00011 16701190
    [Google Scholar]
  43. Peng P.W.H. Wijeysundera D.N. Li C.C.F. Use of gabapentin for perioperative pain control -- A meta-analysis. Pain Res. Manag. 2007 12 2 85 92 10.1155/2007/840572 17505569
    [Google Scholar]
  44. Verret M. Lauzier F. Zarychanski R. Perron C. Savard X. Pinard A.M. Leblanc G. Cossi M.J. Neveu X. Turgeon A.F. Canadian Perioperative Anesthesia Clinical Trials (PACT) Group Perioperative use of gabapentinoids for the management of postoperative acute pain. Anesthesiology 2020 133 2 265 279 10.1097/ALN.0000000000003428 32667154
    [Google Scholar]
  45. Xuan C. Yan W. Wang D. Li C. Ma H. Mueller A. Chin V. Houle T.T. Wang J. Efficacy of preemptive analgesia treatments for the management of postoperative pain: A network meta-analysis. Br. J. Anaesth. 2022 129 6 946 958 10.1016/j.bja.2022.08.038 36404458
    [Google Scholar]
  46. Zhang J. Ho K.Y. Wang Y. Efficacy of pregabalin in acute postoperative pain: A meta-analysis. Br. J. Anaesth. 2011 106 4 454 462 10.1093/bja/aer027 21357616
    [Google Scholar]
  47. Tsai S.H.L. Hu C.W. El Sammak S. Durrani S. Ghaith A.K. Lin C.C.J. Krzyż E.Z. Bydon M. Fu T.S. Lin T.Y. Different gabapentin and pregabalin dosages for perioperative pain control in patients undergoing spine surgery. JAMA Netw. Open 2023 6 8 e2328121 10.1001/jamanetworkopen.2023.28121 37556139
    [Google Scholar]
  48. Kim S.Y. Lee S. Lee Y. Kim H. Kim K.M. Effect of single dose preoperative intravenous ibuprofen on postoperative pain and opioid consumption: A systematic review and meta-analysis. Korean J. Anesthesiol. 2021 74 5 409 421 10.4097/kja.21050 33611881
    [Google Scholar]
  49. De Oliveira G.S. Jr Agarwal D. Benzon H.T. Perioperative single dose ketorolac to prevent postoperative pain: A meta-analysis of randomized trials. Anesth. Analg. 2012 114 2 424 433 10.1213/ANE.0b013e3182334d68 21965355
    [Google Scholar]
  50. de Baaij J.H.F. Hoenderop J.G.J. Bindels R.J.M. Magnesium in man: Implications for health and disease. Physiol. Rev. 2015 95 1 1 46 10.1152/physrev.00012.2014 25540137
    [Google Scholar]
  51. Kirksey M.A. Haskins S.C. Cheng J. Liu S.S. Local anesthetic peripheral nerve block adjuvants for prolongation of analgesia: A systematic qualitative review. PLoS One 2015 10 9 e0137312 10.1371/journal.pone.0137312 26355598
    [Google Scholar]
  52. De Oliveira G.S. Jr Castro-Alves L.J. Khan J.H. McCarthy R.J. Perioperative systemic magnesium to minimize postoperative pain: A meta-analysis of randomized controlled trials. Anesthesiology 2013 119 1 178 190 10.1097/ALN.0b013e318297630d 23669270
    [Google Scholar]
  53. Albrecht E. Kirkham K.R. Liu S.S. Brull R. Peri‐operative intravenous administration of magnesium sulphate and postoperative pain: A meta‐analysis. Anaesthesia 2013 68 1 79 90 10.1111/j.1365‑2044.2012.07335.x 23121612
    [Google Scholar]
  54. Ng K.T. Yap J.L.L. Izham I.N. Teoh W.Y. Kwok P.E. Koh W.J. The effect of intravenous magnesium on postoperative morphine consumption in noncardiac surgery. Eur. J. Anaesthesiol. 2020 37 3 212 223 10.1097/EJA.0000000000001164 31977626
    [Google Scholar]
  55. Heybati K. Zhou F. Baltazar M. Poudel K. Ochal D. Ellythy L. Deng J. Chelf C.J. Welker C. Ramakrishna H. Appraisal of postoperative outcomes of volatile and intravenous anesthetics: A network meta-analysis of patients undergoing cardiac surgery. J. Cardiothorac. Vasc. Anesth. 2023 37 11 2215 2222 10.1053/j.jvca.2023.07.011 37573213
    [Google Scholar]
  56. Schubert A.K. Seneviratne V. Stolz J. Wiesmann T. Wulf H. Eberhart L. Dinges H.C. The effect of adjuvants added to local anaesthetics for single-injection upper extremity peripheral regional anaesthesia. Eur. J. Anaesthesiol. 2023 40 9 672 690 10.1097/EJA.0000000000001860 37337656
    [Google Scholar]
  57. Correll D.J. Vlassakov K.V. Kissin I. No evidence of real progress in treatment of acute pain, 1993-2012: Scientometric analysis. J. Pain Res. 2014 7 199 210 24748816
    [Google Scholar]
  58. Gan T.J. Poorly controlled postoperative pain: Prevalence, consequences, and prevention. J. Pain Res. 2017 10 2287 2298 10.2147/JPR.S144066 29026331
    [Google Scholar]
  59. Mills E.J. Thorlund K. Ioannidis J.P.A. Demystifying trial networks and network meta-analysis. BMJ 2013 346 f2914 10.1136/bmj.f2914 23674332
    [Google Scholar]
  60. lngrande J. Opioid-free anesthesia. Comment Anesthesiology. 2021 135 4 753 755 10.1097/ALN.0000000000003909 34388825
    [Google Scholar]
  61. Bongiovanni T. Lancaster E. Ledesma Y. Whitaker E. Steinman M.A. Allen I.E. Auerbach A. Wick E. Systematic review and meta–analysis of the association between non–steroidal anti–inflammatory drugs and operative bleeding in the perioperative period. J. Am. Coll. Surg. 2021 232 5 765 790e1 10.1016/j.jamcollsurg.2021.01.005 33515678
    [Google Scholar]
  62. Kissin I. Patient-controlled-analgesia analgesimetry and its problems. Anesth. Analg. 2009 108 6 1945 1949 10.1213/ane.0b013e3181a1a481 19448227
    [Google Scholar]
  63. Austin K.L. Stapleton J.V. Mather L.E. Relationship between blood meperidine concentrations and analgesic response: A preliminary report. Anesthesiology 1980 53 6 460 466 10.1097/00000542‑198012000‑00005 7457961
    [Google Scholar]
  64. Kissin I. Bright C.A. Bradley E.L. Jr The effect of ketamine on opioid-induced acute tolerance: Can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations? Anesth. Analg. 2000 91 6 1483 1488 10.1097/00000539‑200012000‑00035 11094005
    [Google Scholar]
  65. Bingham A.E. Fu R. Horn J.L. Abrahams M.S. Continuous peripheral nerve block compared with single-injection peripheral nerve block: A systematic review and meta-analysis of randomized controlled trials. Reg. Anesth. Pain Med. 2012 37 6 583 594 10.1097/AAP.0b013e31826c351b 23080349
    [Google Scholar]
  66. Borgeat A. Single-shot interscalene block. Anesth. Analg. 2015 120 5 995 996 10.1213/ANE.0000000000000660 25899266
    [Google Scholar]
  67. Singh N.P. Makkar J.K. Kuberan A. Guffey R. Uppal V. Efficacy of regional anesthesia techniques for postoperative analgesia in patients undergoing major oncologic breast surgeries: A systematic review and network meta-analysis of randomized controlled trials. Can. J. Anaesth. 2022 69 4 527 549 10.1007/s12630‑021‑02183‑z 35102494
    [Google Scholar]
  68. Barry G. Sehmbi H. Retter S. Bailey J.G. Tablante R. Uppal V. Comparative efficacy and safety of non-neuraxial analgesic techniques for midline laparotomy: A systematic review and frequentist network meta-analysis of randomised controlled trials. Br. J. Anaesth. 2023 131 6 1053 1071 10.1016/j.bja.2023.08.024 37770254
    [Google Scholar]
  69. Kissin I. Scientometric assessment of drugs for chronic pain, 1979–2013: Rapid growth of publications, paucity of successful drugs. J. Pain Res. 2014 7 505 514 10.2147/JPR.S67479 25187736
    [Google Scholar]
/content/journals/crcep/10.2174/0127724328327509240919102209
Loading
Nonopioid Drugs for Postoperative Pain: A Selection Governed by Choices of the Authors of Academic Articles
Bentham Science Publishers ; https://doi.org/10.2174/0127724328327509240919102209
/content/journals/crcep/10.2174/0127724328327509240919102209
/content/journals/crcep/10.2174/0127724328327509240919102209
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: nonopioid analgesics ; postoperative pain ; Nonopioid ; opioid crisis ; academic articles

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test