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- Volume 9, Issue 1, 2020
Current Psychopharmacology - Volume 9, Issue 1, 2020
Volume 9, Issue 1, 2020
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In Search of Reward Deficiency Syndrome (RDS)-Free Controls: The “Holy Grail” in Genetic Addiction Risk Testing
Background: The search for an accurate, gene-based test to identify heritable risk factors for Reward Deficiency Syndrome (RDS) was conducted based on hundreds of published studies about the role of dopamine in addictive behaviors, including risk for drug dependence and compulsive/impulsive behavior disorders. The term RDS was first coined by Blum’s group in 1995 to identify a group of behaviors with a Read More
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Oxidative Stress Targeting Amyloid Beta Accumulation and Clearance in Alzheimer’s Disease: Insight into Pathological Mechanisms and Therapeutic Strategies
Authors: Sunpreet Kaur, Puneet Kumar and Shamsher SinghBackground: Alzheimer’s disease is the most common neurodegenerative disorder affecting the elderly population and emerges as a leading challenge for the scientific research community. The wide pathological aspects of AD made it a multifactorial disorder and even after long time it’s difficult to treat due to unexplored etiological factors. Methods: The etiogenesis of AD includes mitochondrial failure, gut dysbiosis, bioch Read More
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Amelioration of Dementia and Antioxidant Activity of Holarrhena antidysenterica Bark in Mice
Authors: Jasleen Kaur, Manish Kumar and Nitin BansalBackground: Holarrhena antidysenterica is a deciduous shrub/small-tree having bioactive alkaloids such as conessine, known for astringent, antidysenteric, anthelmintic, stomachic, febrifugal, tonic and anti-acetylcholinesterase properties. Dementia is an age related neurodegenerative syndrome with Alzheimer’s disease, the most prominent cause, which has limited therapeutic options available. Objective: The present s Read More
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Evaluation of the Antidepressant Like Activity of Ethanolic Extract of Calendula officinalis using Rodent Models (Wistar Rat) of Depression
Authors: Kaur Rajwinder, Rajmeet Singh, Lalit, Kaur Jaswinder and RajatBackground: Depression disorder has been considered to be the global common psychological CNS disorder affecting about 121 million people worldwide and is among the leading causes of disability that not only inflicts suffering but also carries a high economic burden. Calendula officinalis L. (Marigold) is globally known for its medicinal importance containing various phytochemicals including terpenoids, quinones, coumarins Read More
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Nitrous Oxide-induced Impairment of Spatial Working Memory Requires Activation of GABAergic Pathways
Background: Previous research from our laboratory implicated opioid and benzodiazepine- GABA mechanisms in other effects of N2O (antinociception and anxiolysis), so a decision was made to study these as potential mechanisms of N2O-induced dysfunction of spatial working memory. Objective: to explore potential mechanisms of N2O in reducing spatial working memory in mice. Methods: we monitored spont Read More
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