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Volume 21, Issue 1
  • ISSN: 1573-3963
  • E-ISSN: 1875-6336

Abstract

Background

Omega-3 fatty acids (FAs) are essential long-chain polyunsaturated fatty acids (LCPUFAs) that are essential for optimal health and development.

Objective

The present study aimed to evaluate the effectiveness of maternal fish oil (containing omega-3 LCPUFA) intake from 21th week of pregnancy to 30 days postpartum for neurodevelopment and growth of infants at 9 and 12 months.

Methods

This was a follow-up study of a triple-blinded clinical trial. The study population was 9- month-old infants. Their mothers were randomly divided into two groups of 75 people with a 1:1 ratio to take one fish oil supplement or a placebo daily. The anthropometric indicators of infants at months 9 and 12 and neurodevelopment at month 12 by the ASQ questionnaire were measured. In the fish oil and placebo groups, respectively, 73 and 71 infants at nine months, as well as 71 and 69 at 12 months, were analyzed.

Results

No statistically significant impact was observed following consuming omega-3 capsules on the neurodevelopmental domains, growth parameters, and the profile of maternal serum FAs ( > 0.05) except DHA. Neurodevelopmental problems were illustrated in one case in the intervention group and two cases in the placebo group.

Conclusion

Perinatal relatively low-dose omega-3 LCPUFAs supplements indicated no statistically significant impacts on the growth and neurodevelopment of 9- and 12-month-old infants in a population with low consumption of marine products. Further studies investigating the effect of higher doses of omega-3 LCPUFAs are suggested.

Clinical Trial Registration Number

IRCT2013100914957N1

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2025-01-01
2024-11-01

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References

  1. AndersonL.M. ShinnC. FulliloveM.T. ScrimshawS.C. FieldingJ.E. NormandJ. Carande-KulisV.G. Task Force on Community Preventive Services The effectiveness of early childhood development programs.Am. J. Prev. Med.2003243Suppl.324610.1016/S0749‑3797(02)00655‑412668197
     [Google Scholar]
  2. OlangB. FarivarK. HeidarzadehA. StrandvikB. YngveA. Breastfeeding in Iran: Prevalence, duration and current recommendations.Int. Breastfeed. J.200941810.1186/1746‑4358‑4‑819656361
     [Google Scholar]
  3. JasaniB. SimmerK. PatoleS.K. RaoS.C. Long chain polyunsaturated fatty acid supplementation in infants born at term.Cochrane Libr.201720173CD00037610.1002/14651858.CD000376.pub428281303
     [Google Scholar]
  4. RogersL.K. ValentineC.J. KeimS.A. DHA supplementation: Current implications in pregnancy and childhood.Pharmacol. Res.2013701131910.1016/j.phrs.2012.12.00323266567
     [Google Scholar]
  5. TahaeiH. GignacF. PinarA. Fernandez-BarrésS. RomagueraD. VioqueJ. Santa-MarinaL. Subiza-PérezM. LlopS. Soler-BlascoR. ArijaV. Salas-SalvadóJ. TardónA. Riaño-GalánI. SunyerJ. GuxensM. JulvezJ. Omega-3 fatty acid intake during pregnancy and child neuropsychological development: A multi-centre population-based birth cohort study in spain.Nutrients202214351810.3390/nu1403051835276877
     [Google Scholar]
  6. DiauG.Y. HsiehA.T. Sarkadi-NagyE.A. WijendranV. NathanielszP.W. BrennaJ.T. The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system.BMC Med.2005311110.1186/1741‑7015‑3‑1115975147
     [Google Scholar]
  7. FirouzabadiF.D. Shab-BidarS. JayediA. The effects of omega-3 polyunsaturated fatty acids supplementation in pregnancy, lactation, and infancy: An umbrella review of meta-analyses of randomized trials.Pharmacol. Res.202217710610010.1016/j.phrs.2022.10610035104631
     [Google Scholar]
  8. ChowdhuryM.H. GhoshS. KabirM.R. MamunM.A.A. IslamM.S. Effect of supplementary omega-3 fatty acids on pregnant women with complications and pregnancy outcomes: Review from literature.J. Matern. Fetal Neonatal Med.202235132564258010.1080/14767058.2020.178652232643471
     [Google Scholar]
  9. MorgeseM. TrabaceL. Maternal malnutrition in the etiopathogenesis of psychiatric diseases: Role of polyunsaturated fatty acids.Brain Sci.2016632410.3390/brainsci603002427472366
     [Google Scholar]
  10. Delgado-NogueraM.F. CalvacheJ.A. Bonfill CospX. KotanidouE.P. Galli-TsinopoulouA. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development.Cochrane Libr.201520157CD00790110.1002/14651858.CD007901.pub326171898
     [Google Scholar]
  11. MartinezM. Restoring the DHA levels in the brains of Zellweger patients.J. Mol. Neurosci.2001162-330931610.1385/JMN:16:2‑3:30911478386
     [Google Scholar]
  12. ColettaJ.M. BellS.J. RomanA.S. Omega-3 Fatty acids and pregnancy.Rev. Obstet. Gynecol.20103416317121364848
     [Google Scholar]
  13. HellandI.B. SmithL. SaaremK. SaugstadO.D. DrevonC.A. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age.Pediatrics20031111e39e4410.1542/peds.111.1.e3912509593
     [Google Scholar]
  14. MakridesM. DuleyL. OlsenS.F. Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction.Cochrane Libr.20063CD00340210.1002/14651858.CD003402.pub216856006
     [Google Scholar]
  15. MeldrumS.J. D’VazN. SimmerK. DunstanJ.A. HirdK. PrescottS.L. Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: A randomised controlled trial.Br. J. Nutr.201210881443145410.1017/S000711451100687822348468
     [Google Scholar]
  16. MiddletonP. GomersallJ.C. GouldJ.F. ShepherdE. OlsenS.F. MakridesM. Omega-3 fatty acid addition during pregnancy.Cochrane Libr.2018201811CD00340210.1002/14651858.CD003402.pub330480773
     [Google Scholar]
  17. OstadrahimiA. Salehi-pourmehrH. Mohammad-Alizadeh-CharandabiS. HeidarabadyS. Farshbaf-KhaliliA. The effect of perinatal fish oil supplementation on neurodevelopment and growth of infants: A randomized controlled trial.Eur. J. Nutr.20185772387239710.1007/s00394‑017‑1512‑128752418
     [Google Scholar]
  18. SamimiM. JamilianM. AsemiZ. EsmaillzadehA. Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial.Clin. Nutr.201534338839310.1016/j.clnu.2014.06.00524973862
     [Google Scholar]
  19. MeyliaK.N. SiswatiT. ParamashantiB.A. HatiF.S. Fine motor, gross motor, and social independence skills among stunted and non-stunted children.Early Child Dev. Care202219219510210.1080/03004430.2020.1739028
     [Google Scholar]
  20. GonzalezS.L. AlvarezV. NelsonE.L. Do gross and fine motor skills differentially contribute to language outcomes? A systematic review.Front. Psychol.201910267010.3389/fpsyg.2019.0267031849775
     [Google Scholar]
  21. ElbersJ. MacnabA. McLeodE. GagnonF. The ages and stages questionnaires: Feasibility of use as a screening tool for children in Canada.Can. J. Rural Med.200813191418208647
     [Google Scholar]
  22. BradleyR.H. CorwynR.F. Socioeconomic status and child development.Annu. Rev. Psychol.200253137139910.1146/annurev.psych.53.100901.13523311752490
     [Google Scholar]
  23. WierengaK.A. PestkaJ.J. Omega-3 fatty acids and inflammation - you are what you eat!Front. Young Minds2021960106810.3389/frym.2021.60106835174177
     [Google Scholar]
  24. RegaladoM. HalfonN. Primary care services promoting optimal child development from birth to age 3 years: Review of the literature.Arch. Pediatr. Adolesc. Med.2001155121311132210.1001/archpedi.155.12.131111732949
     [Google Scholar]
  25. LvS. QinR. JiangY. LvH. LuQ. TaoS. HuangL. LiuC. XuX. WangQ. LiM. LiZ. DingY. SongC. JiangT. MaH. JinG. XiaY. WangZ. GengS. DuJ. LinY. HuZ. Association of maternal dietary patterns during gestation and offspring neurodevelopment.Nutrients202214473010.3390/nu1404073035215380
     [Google Scholar]
  26. MartinsB.P. BandarraN.M. Figueiredo-BragaM. The role of marine omega-3 in human neurodevelopment, including autism spectrum disorders and attention-deficit/hyperactivity disorder – A review.Crit. Rev. Food Sci. Nutr.20206091431144610.1080/10408398.2019.157380030880398
     [Google Scholar]
  27. BravemanP.A. EgerterS.A. WoolfS.H. MarksJ.S. When do we know enough to recommend action on the social determinants of health?Am. J. Prev. Med.2011401Suppl. 1S58S6610.1016/j.amepre.2010.09.02621146780
     [Google Scholar]
  28. Grantham-McGregorS. CheungY.B. CuetoS. GlewweP. RichterL. StruppB. International Child Development Steering Group Developmental potential in the first 5 years for children in developing countries.Lancet20073699555607010.1016/S0140‑6736(07)60032‑417208643
     [Google Scholar]
  29. TorabiF. Amir Ali AkbariS. AmiriS. SoleimaniF. Alavi MajdH. Correlation between high-risk pregnancy and developmental delay in children aged 4–60 months.Libyan J. Med.2012711881110.3402/ljm.v7i0.1881123008747
     [Google Scholar]
  30. CalderonF. KimH.Y. Docosahexaenoic acid promotes neurite growth in hippocampal neurons.J. Neurochem.200490497998810.1111/j.1471‑4159.2004.02520.x15287904
     [Google Scholar]
  31. NiuS.L. MitchellD.C. LimS.Y. WenZ.M. KimH.Y. SalemN.Jr LitmanB.J. Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency.J. Biol. Chem.200427930310983110410.1074/jbc.M40437620015145938
     [Google Scholar]
  32. Heras-MolinaA. Pesantez-PachecoJ.L. AstizS. Garcia-ContrerasC. Vazquez-GomezM. EncinasT. ÓviloC. IsabelB. Gonzalez-BulnesA. Maternal supplementation with polyphenols and omega-3 fatty acids during pregnancy: Effects on growth, metabolism, and body composition of the offspring.Animals20201011194610.3390/ani1011194633105758
     [Google Scholar]
  33. ghavamzadeh NazeriN. Determining the effect of maternal omega-3 supplementation during lactation on growth and development of infants.Majallah-i Pizishki-i Urumiyyah201727121048105710.18869/acadpub.umj.27.12.1048
     [Google Scholar]
  34. SacconeG. BerghellaV. MaruottiG.M. SarnoL. MartinelliP. Omega-3 supplementation during pregnancy to prevent recurrent intrauterine growth restriction: Systematic review and meta-analysis of randomized controlled trials.Ultrasound Obstet. Gynecol.201546665966410.1002/uog.1491026033362
     [Google Scholar]
  35. GouldJ.F. TreyvaudK. YellandL.N. AndersonP.J. SmithersL.G. GibsonR.A. McPheeA.J. MakridesM. Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial.BMJ Open201665e01146510.1136/bmjopen‑2016‑01146527188814
     [Google Scholar]
  36. GaleC.R. RobinsonS.M. GodfreyK.M. LawC.M. SchlotzW. O’CallaghanF.J. Oily fish intake during pregnancy – association with lower hyperactivity but not with higher full-scale IQ in offspring.J. Child Psychol. Psychiatry200849101061106810.1111/j.1469‑7610.2008.01908.x18422546
     [Google Scholar]
  37. CarlsonS.E. ColomboJ. GajewskiB.J. GustafsonK.M. MundyD. YeastJ. GeorgieffM.K. MarkleyL.A. KerlingE.H. ShaddyD.J. DHA supplementation and pregnancy outcomes.Am. J. Clin. Nutr.201397480881510.3945/ajcn.112.05002123426033
     [Google Scholar]
  38. van GoorS.A. Janneke Dijck-BrouwerD.A. DoornbosB. ErwichJ.J.H.M. SchaafsmaA. MuskietF.A.J. Hadders-AlgraM. Supplementation of DHA but not DHA with arachidonic acid during pregnancy and lactation influences general movement quality in 12-week-old term infants.Br. J. Nutr.2010103223524210.1017/S000711450999152819703327
     [Google Scholar]
  39. HibbelnJ.R. DavisJ.M. SteerC. EmmettP. RogersI. WilliamsC. GoldingJ. Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): An observational cohort study.Lancet2007369956157858510.1016/S0140‑6736(07)60277‑317307104
     [Google Scholar]
  40. JensenC.L. Effects of n−3 fatty acids during pregnancy and lactation.Am. J. Clin. Nutr.2006836Suppl.1452S1457S10.1093/ajcn/83.6.1452S16841854
     [Google Scholar]
/content/journals/cpr/10.2174/0115733963273591231214112617
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The Effectiveness of Perinatal Omega-3 Supplements in Neurodevelopment and Physical Growth of 9- and 12-month-old Infants: A Follow-up of a Clinical Trial
Curr Pediatr Rev 21, 91 (2025); https://doi.org/10.2174/0115733963273591231214112617
/content/journals/cpr/10.2174/0115733963273591231214112617
/content/journals/cpr/10.2174/0115733963273591231214112617
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  • Article Type: Research Article
Keyword(s): Docosahexaenoic acid; eicosapentaenoic acid; future generation; health care; pregnancy outcomes; supplementation

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