Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) - Volume 9, Issue 2, 2011

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Over evolutionary time, human mitochondrial DNA (mtDNA) has accumulated many mutations. Because mtDNA is exclusively inherited from the maternal lineage, these mtDNA mutations have given rise to different mtDNA genetic backgrounds, or haplogroups. Human mtDNA codes subunits of the oxidative phosphorylation system and the RNAs required for the expression of these subunits. As this cell pathway is significant in Read More

Tardive dyskinesia (TD) is a serious adverse effect often associated with the first generation antipsychotic medications used in the management of mental health disorders such as schizophrenia. Pharmacogenomics is the study of human genomic variation in relation to individual and population variability in medication response and side effects. Neuropsychiatry is one of the clinical domains in which pharmacogenomic approache Read More

Although target-based approach has yielded novel drugs in many therapeutic fields, this approach remains suboptimal and slows the pace of innovations for drug discovery in central nervous system (CNS) disorders. This is because the target identification requires a hierarchical integration from in vitro cellular and functional tissue studies to animal models that reasonably predict drug effects in humans. Because the majorit Read More

Hepatitis C virus (HCV) has emerged as a major viral pandemic over the past two decades, infecting 170 million individuals worldwide. Egypt has the highest prevalence of hepatitis C in the world with prevalence rates of 13%- 15% of the population. Hepatitis C is characterized with its high tendency to induce chronic progressive liver damage in the form of hepatic fibrosis, cirrhosis or liver cancer. There is no vaccine against Read More

One of the most significant barriers to personalized medicine is effective linkage of scientific discoveries from bench to improved therapeutic outcomes at the bedside, and at the level of health systems and services more broadly. Translational bioinformatics is an emerging field that provides powerful new methods to bridge the gaps between biomedical sciences, clinical practice and population sciences. These objecti Read More