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Volume 30, Issue 33
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background

Chronic Myeloid Leukemia (CML) is a rare myeloproliferative disease in childhood. Treatment in CML includes Tyrosine Kinase Inhibitors (TKIs), which inhibit the cytoplasmic kinase BCR/ABL. Tyrosine kinases play a key role in the secretion of growth hormone and insulin-like growth factor 1 (IGF-1).

Objective

The aim of this systematic review was to study the effect of TKIs on the growth of children and adolescents with CML.

Methods

English-language publications were searched in the PubMed/Cochrane library/Google Scholar databases (2002-2023), and retrieved studies were assessed according to PRISMA-Statement and Newcastle-Ottawa-scale.

Results

The search strategy yielded 1066 articles. After applying the inclusion/exclusion criteria, 941 were excluded based on title screening and 111 on abstract review. The systematic review included 14 articles (11 retrospective observational studies/3 clinical trials). Twelve studies reported data on the prevalence of growth disorders after the administration of 1st generation TKIs (imatinib). Two studies reported a negative effect of 2nd generation TKIs (dasatinib/nilotinib) on physical growth. Four studies recorded a decrease in height z-score after treatment compared to baseline. Two 1st-generation TKIs studies reported data on children's final height; one reported restoration of final height to normal after the onset of puberty, despite initial slowing, and the final height was lower than mid-parental target height. Serum IGF-1 levels were reported in 2 studies to be within normal range, while in 3 studies, a significant decrease was documented. Considerable study heterogeneity was observed related to dosage/duration of treatment/disease phase/stage of puberty/ethnicity.

Conclusion

A negative effect of TKIs on the growth and final height of children was noted.

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References

  1. MinciacchiV.R. KumarR. KrauseD.S. Chronic myeloid leukemia: A model disease of the past, present and future.Cells202110111710.3390/cells1001011733435150
     [Google Scholar]
  2. FordM. MauroM. AftandilianC. SakamotoK.M. HijiyaN. Management of chronic myeloid leukemia in children and young adults.Curr. Hematol. Malig. Rep.202217512112610.1007/s11899‑022‑00673‑535920965
     [Google Scholar]
  3. RobertsonH.F. ApperleyJ.F. Treatment of CML in pregnancy.Hematology20222022112312810.1182/hematology.202200033036485083
     [Google Scholar]
  4. WangY. JiangL. LiB. ZhaoY. Management of chronic myeloid leukemia and pregnancy: A bibliometric analysis (2000-2020).Front. Oncol.20221282670310.3389/fonc.2022.82670335321439
     [Google Scholar]
  5. ZhouT. MedeirosL.J. HuS. Chronic myeloid leukemia: Beyond BCR-ABL1.Curr. Hematol. Malig. Rep.201813643544510.1007/s11899‑018‑0474‑630370478
     [Google Scholar]
  6. AliM.A.M. chronic myeloid leukemia in the era of tyrosine kinase inhibitors: An evolving paradigm of molecularly targeted therapy.Mol. Diagn. Ther.201620431533310.1007/s40291‑016‑0208‑127220498
     [Google Scholar]
  7. KomorowskiL. FidytK. PatkowskaE. FirczukM. Philadelphia chromosome-positive leukemia in the lymphoid lineage similarities and differences with the myeloid lineage and specific vulnerabilities.Int. J. Mol. Sci.20202116577610.3390/ijms2116577632806528
     [Google Scholar]
  8. SattlermcM. GriffinJ.D. Molecular mechanisms of transformation by the BCR-ABL oncogene.Semin. Hematol.2003402Suppl. 241010.1053/shem.2003.5003412783368
     [Google Scholar]
  9. SmithS.M. HijiyaN. SakamotoK.M. Chronic myelogenous leukemia in childhood.Curr. Oncol. Rep.20212344010.1007/s11912‑021‑01025‑x33718985
     [Google Scholar]
  10. SuttorpM. ClaviezA. BaderP. PetersC. GadnerH. EbellW. DillooD. KremensB. KabischH. FührerM. ZintlF. GöbelU. KlingebielT. Allogeneic stem cell transplantation for pediatric and adolescent patients with CML: Results from the prospective trial CML-paed I.Klin. Padiatr.2009221635135710.1055/s‑0029‑123952919890786
     [Google Scholar]
  11. YangK. FuL. Mechanisms of resistance to BCR–ABL TKIs and the therapeutic strategies: A review.Crit. Rev. Oncol. Hematol.201593327729210.1016/j.critrevonc.2014.11.00125500000
     [Google Scholar]
  12. LiC. WenL. DongJ. LiL. HuangJ. YangJ. LiangT. LiT. XiaZ. ChenC. Alterations in cellular metabolisms after TKI therapy for Philadelphia chromosome-positive leukemia in children: A review.Front. Oncol.202212107280610.3389/fonc.2022.107280636561525
     [Google Scholar]
  13. CortesJ. PavlovskyC. SaußeleS. Chronic myeloid leukaemia.Lancet2021398103141914192610.1016/S0140‑6736(21)01204‑634425075
     [Google Scholar]
  14. ChenY. WangH. KantarjianH. CortesJ. Trends in chronic myeloid leukemia incidence and survival in the United States from 1975 to 2009.Leuk. Lymphoma20135471411141710.3109/10428194.2012.74552523121646
     [Google Scholar]
  15. HochhausA. BaccaraniM. SilverR.T. SchifferC. ApperleyJ.F. CervantesF. ClarkR.E. CortesJ.E. DeiningerM.W. GuilhotF. Hjorth-HansenH. HughesT.P. JanssenJ.J.W.M. KantarjianH.M. KimD.W. LarsonR.A. LiptonJ.H. MahonF.X. MayerJ. NicoliniF. NiederwieserD. PaneF. RadichJ.P. ReaD. RichterJ. RostiG. RousselotP. SaglioG. SaußeleS. SoveriniS. SteegmannJ.L. TurkinaA. ZaritskeyA. HehlmannR. European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.Leukemia202034496698410.1038/s41375‑020‑0776‑232127639
     [Google Scholar]
  16. SembillS. AmpatzidouM. ChaudhuryS. DworzakM. KalwakK. KarowA. KianiA. KrumbholzM. LuesinkM. Naumann-BartschN. De MoerlooseB. OsbornM. SchultzK.R. SedlacekP. GionaF. ZwaanC.M. ShimadaH. VersluijsB. MillotF. HijiyaN. SuttorpM. MetzlerM. Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations.Leukemia202337350551710.1038/s41375‑023‑01822‑236707619
     [Google Scholar]
  17. MuramatsuH. TakahashiY. SakaguchiH. ShimadaA. NishioN. HamaA. DoisakiS. YagasakiH. MatsumotoK. KatoK. KojimaS. Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era.Int. J. Hematol.201193218619110.1007/s12185‑010‑0764‑921234820
     [Google Scholar]
  18. US Food & Drug Administration (FDA). Glivec. Summary of product characteristics.Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021588s024lbl.pdf (2021 Jun 19).
  19. European Medicines Agency (EMEA)Glivec. Summary of product characteristics.2021Available from: https://www.ema.europa.eu/en/medicines/human/EPAR/glivec
  20. GoreL. KearnsP.R. de MartinoM.L. Lee De SouzaC.A. BertrandY. HijiyaN. StorkL.C. ChungN.G. CardosR.C. SaikiaT. FagioliF. SeoJ.J. Landman-ParkerJ. LancasterD. PlaceA.E. RabinK.R. SacchiM. SwaninkR. ZwaanC.M. Dasatinib in pediatric patients with chronic myeloid leukemia in chronic phase: Results from a phase II trial.J. Clin. Oncol.201836131330133810.1200/JCO.2017.75.959729498925
     [Google Scholar]
  21. LarsonR.A. YinO.Q.P. HochhausA. SaglioG. ClarkR.E. NakamaeH. GallagherN.J. DemirhanE. HughesT.P. KantarjianH.M. le CoutreP.D. Population pharmacokinetic and exposure-response analysis of nilotinib in patients with newly diagnosed Ph+ chronic myeloid leukemia in chronic phase.Eur. J. Clin. Pharmacol.201268572373310.1007/s00228‑011‑1200‑722207416
     [Google Scholar]
  22. LindauerM. HochhausA. Dasatinib.Recent Results Cancer Res.20101848310210.1007/978‑3‑642‑01222‑8_720072833
     [Google Scholar]
  23. McCaffertyE.H. DhillonS. DeeksE.D. Dasatinib: A review in pediatric chronic myeloid leukemia.Paediatr. Drugs201820659360010.1007/s40272‑018‑0319‑830465234
     [Google Scholar]
  24. US Food & Drug Administration (FDA). Tasigna. Summary of product characteristics.Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022068s004s005lbl.pdf 2021
  25. European Medicines Agency (EMEA)Tasigna. Summary of product characteristics.Available from: https://www.ema.europa.eu/en/documents/productinformation/tasignaeparproductinformation_en.pdf (2021 Apr 8.).
  26. KaradaşN. GöktepeŞ.Ş.Ö. Başİ. EceD. ÖzdemirH.H. BalkanC. KavaklıK. AydinokY. KarapinarD.Y. Current childhood chronic myeloid leukemia management under tyrosine kinase inhibitor treatment.Int. J. Hematol.2023117344645510.1007/s12185‑022‑03497‑436401784
     [Google Scholar]
  27. HijiyaN. MillotF. SuttorpM. Chronic myeloid leukemia in children: Clinical findings, management, and unanswered questions.Pediatr. Clin. North Am.201562110711910.1016/j.pcl.2014.09.00825435115
     [Google Scholar]
  28. SunL.R. WangL.Z. ZhongR. ZhaoY.X. SunY. Tyrosine kinase inhibitors for pediatric leukemia: History and current status.Discov. Med.202233169939936274227
     [Google Scholar]
  29. AmpatzidouM. PapadhimitriouS.I. GoussetisE. PanagiotouJ.P. PapadakisV. PolychronopoulouS. Chronic myeloid leukemia (CML) in children: Classical and newer therapeutic approaches.Pediatr. Hematol. Oncol.201229538939410.3109/08880018.2012.69194622690835
     [Google Scholar]
  30. MadabhaviI. PatelA. ModiG. AnandA. PanchalH. ParikhS. Pediatric chronic myeloid leukemia: A single-center experience.J. Cancer Res. Ther.202016111011510.4103/jcrt.JCRT_833_1532362619
     [Google Scholar]
  31. MillotF. TraoreP. GuilhotJ. NelkenB. LeblancT. LevergerG. PlantazD. BertrandY. BordigoniP. GuilhotF. Clinical and biological features at diagnosis in 40 children with chronic myeloid leukemia.Pediatrics2005116114014310.1542/peds.2004‑247315995044
     [Google Scholar]
  32. HijiyaN. SchultzK.R. MetzlerM. MillotF. SuttorpM. Pediatric chronic myeloid leukemia is a unique disease that requires a different approach.Blood2016127439239910.1182/blood‑2015‑06‑64866726511135
     [Google Scholar]
  33. CastagnettiF. GugliottaG. BaccaraniM. BrecciaM. SpecchiaG. LevatoL. AbruzzeseE. RossiG. IurloA. MartinoB. PregnoP. StagnoF. CuneoA. BonifacioM. GobbiM. RussoD. GozziniA. TiribelliM. de VivoA. AlimenaG. CavoM. MartinelliG. PaneF. SaglioG. RostiG. SalviF. PiniM. LeoniP. RupoliS. GalieniP. BigazziC. CantoreN. PalmieriF. AlbanoF. Russo RossiA. RambaldiA. IntermesoliT. PalandriF. TestoniN. LuattiS. SoveriniS. IacobucciI. BochicchioM.T. ApolinariM. FogliM. CervelloI. CapucciA. MalagolaM. MalpignanoA. GirasoliM. AngelucciE. UsalaE. StortiS. De BiasiE. TagarielloG. SartoriR. Di RaimondoF. VigneriP. ImperaS. MolicaS. LanzaF. ViganòC. GrassoM. RapezziD. CavazziniF. BosiA. SantiniV. CapalboS.F. SpinosaG. PierriI. BergamaschiM. CarellaA.M. BacigalupoA. De BlasioA. CicconeF. Di RenzoN. MusolinoC. RussoS. CortelezziA. MorraE. PungolinoE.M. LuppiM. MarascaR. PoglianiE.M. Gambacorti-PasseriniC. LucianoL. FerraraF. AnnunziataM. LatteG. NoliD. Rege-CambrinG. FavaC. SemenzatoG. BinottoG. FabbianoF. TurriD. SiragusaS. CaraccioloC. MussoM. PorrettoF. AversaF. CrugnolaM. CazzolaM. OrlandiE. FaliniB. FalzettiF. VisaniG. IsidoriA. FioritoniG. Di LorenzoR. VallisaD. TrabacchiE. PetriniM. GalimbertiS. PizzutiM. ZaccariaA. SalvucciM. RoncoF. IeloD. MerliF. AvanziniP. TosiP. MerliA. MustoP. De StefanoV. SicaS. LatagliataR. De FabritiisP. TrawiskaM. MajolinoI. PacilliL. RonciB. CedroneM. PettiM.C. PisaniF. TafuriA. MontefuscoE. IulianoF. DoreF. PardiniS. BocchiaM. DefinaM. LiberatiA.M. LuzziD. BoccadoroM. FerreroD. VitoloU. GherlinzoniF. CalistriE. FaninR. PizzoloG. MeneghiniV. RodighieroF. D’EmilioA. Differences among young adults, adults and elderly chronic myeloid leukemia patients.Ann. Oncol.201526118519210.1093/annonc/mdu49025361995
     [Google Scholar]
  34. MoschoviM. KelaidiC. Chronic myeloid leukemia in children and adolescents: The achilles heel of oncogenesis and tyrosine kinase inhibitors.Int. J. Mol. Sci.20212215780610.3390/ijms2215780634360571
     [Google Scholar]
  35. BakhshiS. PushpamD. Paediatric chronic myeloid leukaemia: Is it really a different disease?Indian J. Med. Res.2019149560060910.4103/ijmr.IJMR_331_1931417027
     [Google Scholar]
  36. BarrR.D. Imatinib mesylate in children and adolescents with cancer.Pediatr. Blood Cancer2010551182510.1002/pbc.2248420486169
     [Google Scholar]
  37. ChampagneM.A. CapdevilleR. KrailoM. QuW. PengB. RosamiliaM. TherrienM. ZoellnerU. BlaneyS.M. BernsteinM. Imatinib mesylate (STI571) for treatment of children with Philadelphia chromosome-positive leukemia: Results from a Children’s Oncology Group phase 1 study.Blood200410492655266010.1182/blood‑2003‑09‑303215231574
     [Google Scholar]
  38. SuttorpM. SchulzeP. GlaucheI. GöhringG. von NeuhoffN. MetzlerM. SedlacekP. de BontE.S.J.M. BalduzziA. LausenB. AleinikovaO. SufliarskaS. HenzeG. StraussG. EggertA. KremensB. GrollA.H. BertholdF. KleinC. Groß-WieltschU. SykoraK.W. BorkhardtA. KulozikA.E. SchrappeM. NowaszC. KrumbholzM. TauerJ.T. ClaviezA. HarbottJ. KreipeH.H. SchlegelbergerB. ThiedeC. Front-line imatinib treatment in children and adolescents with chronic myeloid leukemia: Results from a phase III trial.Leukemia20183271657166910.1038/s41375‑018‑0179‑929925908
     [Google Scholar]
  39. European Medicines Agency (EMEA)Sprycel. Summary of product characteristics.Available from: https://www.ema.europa.eu/en/documents/productinformation/spryceleparproductinformation_en.pdf (2021 Apr 8).
  40. US Food & Drug Administration (FDA). Sprycel. Summary of product characteristics.Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021986s020lbl.pdf (2021 Jun 19).
  41. HochhausA. SaglioG. HughesT.P. LarsonR.A. KimD-W. IssaragrisilS. le CoutreP.D. EtienneG. Dorlhiac-LlacerP.E. ClarkR.E. FlinnI.W. NakamaeH. DonohueB. DengW. DalalD. MenssenH.D. KantarjianH.M. Long-term benefits and risks of frontline nilotinib vs. imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial.Leukemia20163051044105410.1038/leu.2016.526837842
     [Google Scholar]
  42. SuttorpM. YanivI. SchultzK.R. Controversies in the treatment of CML in children and adolescents: TKIs versus BMT?Biol. Blood Marrow Transplant.2011171Suppl.S115S12210.1016/j.bbmt.2010.09.00321195300
     [Google Scholar]
  43. HijiyaN. SuttorpM. How I treat chronic myeloid leukemia in children and adolescents.Blood2019133222374238410.1182/blood.201888223330917954
     [Google Scholar]
  44. HijiyaN. MaschanA. RizzariC. ShimadaH. DufourC. GotoH. KangH.J. GuiniperoT. KarakasZ. BautistaF. DucassouS. YooK.H. ZwaanC.M. MillotF. AimoneP. AllepuzA. QuenetS. Hourcade-PotelleretF. HertleS. SosothikulD. Phase 2 study of nilotinib in pediatric patients with Philadelphia chromosome–positive chronic myeloid leukemia.Blood2019134232036204510.1182/blood.201900006931511239
     [Google Scholar]
  45. CarofiglioF. LopalcoA. LopedotaA. CutrignelliA. NicolottiO. DenoraN. StefanachiA. LeonettiF. Bcr-Abl tyrosine kinase inhibitors in the treatment of pediatric CML.Int. J. Mol. Sci.20202112446910.3390/ijms2112446932586039
     [Google Scholar]
  46. ChemaitillyW. SklarC.A. Childhood cancer treatments and associated endocrine late effects: A concise guide for the pediatric endocrinologist.Horm. Res. Paediatr.2019912748210.1159/00049394330404091
     [Google Scholar]
  47. Sarkis-OnofreR. Catalá-LópezF. AromatarisE. LockwoodC. How to properly use the PRISMA Statement.Syst. Rev.202110111710.1186/s13643‑021‑01671‑z33875004
     [Google Scholar]
  48. RethlefsenM.L. KirtleyS. WaffenschmidtS. AyalaA.P. MoherD. PageM.J. KoffelJ.B. BluntH. BrighamT. ChangS. ClarkJ. ConwayA. CoubanR. de KockS. FarrahK. FehrmannP. FosterM. FowlerS.A. GlanvilleJ. HarrisE. HoffeckerL. IsojarviJ. KaunelisD. KetH. LevayP. LyonJ. McGowanJ. MuradM.H. NicholsonJ. PannabeckerV. PaynterR. PinottiR. Ross-WhiteA. SampsonM. ShieldsT. StevensA. SuttonA. WeinfurterE. WrightK. YoungS. PRISMA-S: An extension to the PRISMA statement for reporting literature searches in systematic reviews.Syst. Rev.20211013910.1186/s13643‑020‑01542‑z33499930
     [Google Scholar]
  49. HuttonB. SalantiG. CaldwellD.M. ChaimaniA. SchmidC.H. CameronC. IoannidisJ.P.A. StrausS. ThorlundK. JansenJ.P. MulrowC. Catalá-LópezF. GøtzscheP.C. DickersinK. BoutronI. AltmanD.G. MoherD. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: Checklist and explanations.Ann. Intern. Med.20151621177778410.7326/M14‑238526030634
     [Google Scholar]
  50. LiberatiA. AltmanD.G. TetzlaffJ. MulrowC. GøtzscheP.C. IoannidisJ.P.A. ClarkeM. DevereauxP.J. KleijnenJ. MoherD. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration.J. Clin. Epidemiol.20096210e1e3410.1016/j.jclinepi.2009.06.00619631507
     [Google Scholar]
  51. MoherD. LiberatiA. TetzlaffJ. AltmanD.G. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement.BMJ2009339jul21 1b253510.1136/bmj.b2535
     [Google Scholar]
  52. PageM.J. McKenzieJ.E. BossuytP.M. BoutronI. HoffmannT.C. MulrowC.D. ShamseerL. TetzlaffJ.M. AklE.A. BrennanS.E. ChouR. GlanvilleJ. GrimshawJ.M. HróbjartssonA. LaluM.M. LiT. LoderE.W. Mayo-WilsonE. McDonaldS. McGuinnessL.A. StewartL.A. ThomasJ. TriccoA.C. WelchV.A. WhitingP. MoherD. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews.J. Clin. Epidemiol.202113417818910.1016/j.jclinepi.2021.03.00133789819
     [Google Scholar]
  53. BansalD. ShavaU. VarmaN. TrehanA. MarwahaR.K. Imatinib has adverse effect on growth in children with chronic myeloid leukemia.Pediatr. Blood Cancer201259348148410.1002/pbc.2338922052850
     [Google Scholar]
  54. BodduD. ThankamonyP. GuruprasadC.S. NairM. RajeswariB. SeetharamS. Effect of imatinib on growth in children with chronic myeloid leukemia.Pediatr. Hematol. Oncol.201936418919710.1080/08880018.2019.161011931298597
     [Google Scholar]
  55. CaiY. LiuC. GuoY. ChenX. ZhangL. ChenY. ZouY. YangW. ZhuX. Long-term safety and efficacy of imatinib in pediatric patients with chronic myeloid leukemia: Single- center experience from China.Int. J. Hematol.2021113341342110.1007/s12185‑020‑03042‑133386594
     [Google Scholar]
  56. ChoeyprasertW. YansomdetT. NatesirinilkulR. WejaphikulK. CharoenkwanP. Adverse effects of imatinib in children with chronic myelogenous leukemia.Pediatr. Int.201759328629210.1111/ped.1313627541072
     [Google Scholar]
  57. MillotF. GuilhotJ. BaruchelA. PetitA. LeblancT. BertrandY. MazingueF. LutzP. VéritéC. BerthouC. GalambrunC. SirventN. YacoubenK. ChastagnerP. GandemerV. ReguerreY. CouillaultG. KhalifehT. RiallandF. Growth deceleration in children treated with imatinib for chronic myeloid leukaemia.Eur. J. Cancer201450183206321110.1016/j.ejca.2014.10.00725459396
     [Google Scholar]
  58. NarayananK.R. BansalD. WaliaR. SachdevaN. BhansaliA. VarmaN. MarwahaR.K. Growth failure in children with chronic myeloid leukemia receiving imatinib is due to disruption of GH/IGF-1 axis.Pediatr. Blood Cancer20136071148115310.1002/pbc.2439723322583
     [Google Scholar]
  59. RastogiM.V. StorkL. DrukerB. BlasdelC. NguyenT. BostonB.A. Imatinib mesylate causes growth deceleration in pediatric patients with chronic myelogenous leukemia.Pediatr. Blood Cancer201259584084510.1002/pbc.2412122378641
     [Google Scholar]
  60. ShimaH. TokuyamaM. TanizawaA. TonoC. HamamotoK. MuramatsuH. WatanabeA. HottaN. ItoM. KurosawaH. KatoK. TsurusawaM. HoribeK. ShimadaH. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia.J. Pediatr.2011159467668110.1016/j.jpeds.2011.03.04621592517
     [Google Scholar]
  61. UlmerA. Tabea TauerJ. GlaucheI. JungR. SuttorpM. TK inhibitor treatment disrupts growth hormone axis: Clinical observations in children with CML and experimental data from a juvenile animal model.Klin. Padiatr.2013225312012610.1055/s‑0033‑134348323716272
     [Google Scholar]
  62. WaliaR. AggarwalA. BhansaliA. AggarwalA. VarmaN. SachdevaN. KhandelwalN. BansalD. Acquired neuro-secretory defect in growth hormone secretion due to Imatinib mesylate and the efficacy of growth hormone therapy in children with chronic myeloid leukemia.Pediatr. Hematol. Oncol.20203729910810.1080/08880018.2019.168932031747806
     [Google Scholar]
  63. ZhengY.Z. LiJ. ChenC. ZhengH. FuD.H. HuJ.D. Long-term outcome of tyrosine kinase inhibitor treatment in children and adolescents with newly diagnosed chronic myeloid leukemia in chronic phase.Chin. Med. J.2021134243009301110.1097/CM9.000000000000165634310396
     [Google Scholar]
  64. HijiyaN. MaschanA. RizzariC. ShimadaH. DufourC. GotoH. KangH.J. GuiniperoT. KarakasZ. BautistaF. DucassouS. YooK.H. ZwaanC.M. MillotF. PattersonB. SamisJ. AimoneP. AllepuzA. TitorenkoK. SosothikulD. A phase 2 study of nilotinib in pediatric patients with CML: Long-term update on growth retardation and safety.Blood Adv.20215142925293410.1182/bloodadvances.202000375934309636
     [Google Scholar]
  65. KimotoT. InoueM. KawaK. Growth deceleration in a girl treated with imatinib.Int. J. Hematol.200989225125210.1007/s12185‑008‑0251‑819152100
     [Google Scholar]
  66. KebapcilarL. BilgirO. AlacaciogluI. PayzinB. BilgirF. OnerP. SariI. CalanM. BinicierO. Does imatinib mesylate therapy cause growth hormone deficiency?Med. Princ. Pract.200918536036310.1159/00022628819648757
     [Google Scholar]
  67. SchmidH. JaegerB.A.S. LohseJ. SuttorpM. Longitudinal growth retardation in a prepuberal girl with chronic myeloid leukemia on long-term treatment with imatinib.Haematologica20099481177117910.3324/haematol.2009.00835919546438
     [Google Scholar]
  68. WernerH. The IGF1 signaling pathway: From basic concepts to therapeutic opportunities.Int. J. Mol. Sci.202324191488210.3390/ijms24191488237834331
     [Google Scholar]
  69. BouillonR. Growth hormone and bone.Horm. Res.1991361495510.1159/0001821891806485
     [Google Scholar]
  70. NiwczykO. GrymowiczM. SzczęsnowiczA. HajbosM. KostrzakA. BudzikM. Maciejewska-JeskeM. BalaG. SmolarczykR. MęczekalskiB. Bones and hormones: Interaction between hormones of the hypothalamus, pituitary, adipose tissue and bone.Int. J. Mol. Sci.2023247684010.3390/ijms2407684037047811
     [Google Scholar]
  71. BrooksA.J. WatersM.J. The growth hormone receptor: Mechanism of activation and clinical implications.Nat. Rev. Endocrinol.20106951552510.1038/nrendo.2010.12320664532
     [Google Scholar]
  72. LodishM.B. Clinical review: Kinase inhibitors: Adverse effects related to the endocrine system.J. Clin. Endocrinol. Metab.20139841333134210.1210/jc.2012‑408523450053
     [Google Scholar]
  73. GuptaP. BanothuK.K. HaldarP. GuptaA.K. MeenaJ.P. Effect of imatinib mesylate on growth in pediatric chronic myeloid leukemia: A systematic review and meta-analysis.J. Pediatr. Hematol. Oncol.202345522723410.1097/MPH.000000000000266037027248
     [Google Scholar]
  74. ChulaniV.L. GordonL.P. Adolescent growth and development.Prim. Care201441346548710.1016/j.pop.2014.05.00225124201
     [Google Scholar]
  75. BerenbaumS.A. BeltzA.M. CorleyR. The importance of puberty for adolescent development: Conceptualization and measurement.Adv. Child Dev. Behav.201548539210.1016/bs.acdb.2014.11.00225735941
     [Google Scholar]
  76. CameronJ.L. Interrelationships between hormones, behavior, and affect during adolescence: Understanding hormonal, physical, and brain changes occurring in association with pubertal activation of the reproductive axis. Introduction to part III.Ann. N. Y. Acad. Sci.20041021111012310.1196/annals.1308.01215251880
     [Google Scholar]
  77. RemschmidtH. Psychosocial milestones in normal puberty and adolescence.Horm. Res.1994412192910.1159/0001839558088699
     [Google Scholar]
  78. CronauH. BrownR.T. Growth and development: Physical, mental, and social aspects.Prim. Care1998251234510.1016/S0095‑4543(05)70324‑99469915
     [Google Scholar]
  79. PinyerdB. ZipfW.B. Puberty-timing is everything!J. Pediatr. Nurs.2005202758210.1016/j.pedn.2004.12.01115815567
     [Google Scholar]
  80. GionaF. MarianiS. GnessiL. MoletiM.L. ReaM. De VellisA. MarzellaD. TestiA.M. FoàR. Bone metabolism, growth rate and pubertal development in children with chronic myeloid leukemia treated with imatinib during puberty.Haematologica2013983e25e2710.3324/haematol.2012.06744722983586
     [Google Scholar]
  81. HobernichtS.L. SchweigerB. ZeitlerP. WangM. HungerS.P. Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy.Pediatr. Blood Cancer201156467167310.1002/pbc.2294521298759
     [Google Scholar]
  82. MarianiS. GionaF. BascianiS. BramaM. GnessiL. Low bone density and decreased inhibin-B/FSH ratio in a boy treated with imatinib during puberty.Lancet2008372963311111210.1016/S0140‑6736(08)61023‑518620939
     [Google Scholar]
  83. IbbaA. LocheS. Diagnosis of GH deficiency without GH stimulation tests.Front. Endocrinol.20221385329010.3389/fendo.2022.85329035250894
     [Google Scholar]
  84. O’SullivanS. NaotD. CallonK. PorteousF. HorneA. WattieD. WatsonM. CornishJ. BrowettP. GreyA. Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms.J. Bone Miner. Res.200722111679168910.1359/jbmr.07071917663639
     [Google Scholar]
  85. VandykeK. FitterS. DewarA.L. HughesT.P. ZannettinoA.C.W. Dysregulation of bone remodeling by imatinib mesylate.Blood2010115476677410.1182/blood‑2009‑08‑23740419890095
     [Google Scholar]
  86. VandykeK. DewarA.L. FitterS. MenicaninD. ToL.B. HughesT.P. ZannettinoA.C.W. Imatinib mesylate causes growth plate closure in vivo.Leukemia200923112155215910.1038/leu.2009.15019626049
     [Google Scholar]
  87. SamisJ. LeeP. ZimmermanD. ArceciR.J. SuttorpM. HijiyaN. Recognizing endocrinopathies associated with tyrosine kinase inhibitor therapy in children with chronic myelogenous leukemia.Pediatr. Blood Cancer20166381332133810.1002/pbc.2602827100618
     [Google Scholar]
  88. ZatelliM.C. AmbrosioM.R. BondanelliM. degli UbertiE. Pituitary side effects of old and new drugs.J. Endocrinol. Invest.2014371091792310.1007/s40618‑014‑0133‑225070042
     [Google Scholar]
  89. SuttorpM. MillotF. Treatment of pediatric chronic myeloid leukemia in the year 2010: Use of tyrosine kinase inhibitors and stem-cell transplantation.Hematology20102010136837610.1182/asheducation‑2010.1.36821239821
     [Google Scholar]
  90. PushpamD. BakhshiS. Pharmacology of tyrosine kinase inhibitors in chronic myeloid leukemia; A clinician’s perspective.Daru202028137138510.1007/s40199‑019‑00321‑z31900888
     [Google Scholar]
  91. BrownR.L. Tyrosine kinase inhibitor-induced hypothyroidism: Incidence, etiology, and management.Target. Oncol.20116421722610.1007/s11523‑011‑0197‑222101606
     [Google Scholar]
  92. BasoloA. MatroneA. EliseiR. SantiniF. Effects of tyrosine kinase inhibitors on thyroid function and thyroid hormone metabolism.Semin. Cancer Biol.20227919720210.1016/j.semcancer.2020.12.00833476722
     [Google Scholar]
  93. PatelS. NayernamaA. JonesS.C. de ClaroR.A. WaldronP.E. BCR-ABL1 tyrosine kinase inhibitor-associated thyroid dysfunction: A review of cases reported to the FDA Adverse Event Reporting System and published in the literature.Am. J. Hematol.20209512E332E33510.1002/ajh.2599732918288
     [Google Scholar]
  94. TorinoF. CorselloS.M. LongoR. BarnabeiA. GaspariniG. Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy.Nat. Rev. Clin. Oncol.20096421922810.1038/nrclinonc.2009.419333228
     [Google Scholar]
  95. KimT.D. SchwarzM. NogaiH. GrilleP. WestermannJ. PlöckingerU. BraunD. SchweizerU. ArnoldR. DörkenB. le CoutreP. Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia.Thyroid201020111209121410.1089/thy.2010.025120929406
     [Google Scholar]
  96. BermanE. NicolaidesM. MakiR.G. FleisherM. ChanelS. ScheuK. WilsonB.A. HellerG. SauterN.P. Altered bone and mineral metabolism in patients receiving imatinib mesylate.N. Engl. J. Med.2006354192006201310.1056/NEJMoa05114016687713
     [Google Scholar]
  97. O’SullivanS. HorneA. WattieD. PorteousF. CallonK. GambleG. EbelingP. BrowettP. GreyA. Decreased bone turnover despite persistent secondary hyperparathyroidism during prolonged treatment with imatinib.J. Clin. Endocrinol. Metab.20099441131113610.1210/jc.2008‑232419174494
     [Google Scholar]
/content/journals/cpd/10.2174/0113816128309071240626114308
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Impact of Tyrosine Kinase Inhibitors (TKIs) on Growth in Children and Adolescents with Chronic Myeloid Leukemia: A Systematic Review
Curr. Pharm. Des. 30, 2631 (2024); https://doi.org/10.2174/0113816128309071240626114308
/content/journals/cpd/10.2174/0113816128309071240626114308
/content/journals/cpd/10.2174/0113816128309071240626114308
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  • Article Type:     Review Article
Keyword(s): adolescents; Chronic myeloid leukemia; dasatinib; growth failure; imatinib; nilotinib; tyrosine kinase inhibitors

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