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Volume 30, Issue 33
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background and Aims

The recurrence rate of Colorectal Cancer (CRC) after cure is always high. The purpose of this study was to investigate whether green tea extract (-)-Epigallocatechin gallate (EGCG) has an effective preventive effect on the recurrence of CRC.

Methods

We conducted a systematic literature review and meta-analysis of the effects of taking EGCG or placebo on disease recurrence in patients after colon polyp removal.

Results

Five Randomized Controlled Trials (RCTs) were included in this review. A double-blind drug trial involving 1389 participants involved EGCG and placebo. The results showed no significant publication bias or heterogeneity in the five studies (I2 = 38%; = 0.17). Patients taking EGCG had a lower recurrence rate of CRC than those in the placebo group. The results were statistically significant (Z=2.83, < 0.05).

Conclusion

This study demonstrated that long-term EGCG can prevent CRC recurrence to a certain extent.

© 2024 Bentham Science Publishers
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2024-11-14

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/content/journals/cpd/10.2174/0113816128319678240612114820
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Chemoprophylaxis Effect of EGCG on the Recurrence of Colorectal Cancer: A Systematic Review and Meta-Analysis
Curr. Pharm. Des. 30, 2643 (2024); https://doi.org/10.2174/0113816128319678240612114820
/content/journals/cpd/10.2174/0113816128319678240612114820
/content/journals/cpd/10.2174/0113816128319678240612114820
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  • Article Type:     Research Article
Keyword(s): chemoprophylaxis; Colorectal cancer; EGCG; green tea extract, malignant tumour; recrudescence

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