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Volume 31, Issue 11
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Introduction

The COVID-19 pandemic represents a significant challenge across scientific, medical, and societal dimensions. The unpredictability of the disease progression, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underscores the urgent need for identifying compounds that target multiple aspects of the virus to ensure swift and effective treatment. L., a delicate, perennial, deciduous shrub found across various Asian regions, has been recognized for its wide range of pharmacological benefits, including hepatoprotective, antimalarial, antibacterial, anti-inflammatory, antioxidant, and antiviral properties.

Methods

Various studies revealed the therapeutic significance of against COVID-19. However, the exact molecular mechanism remains unclarified. In the present study, a network pharmacology approach was employed to uncover the active ingredients, their potential targets, and signaling pathways in for the treatment of COVID-19. In the framework of this study, we explored the active ingredient–target–pathway network and figured out that naringetol, ursolic acid, beta-sitosterol, and daucosterol decisively contributed to the development of COVID-19 by affecting IL6, MAPK3, and MDM2 genes.

Results

The results of molecular docking analysis indicated that exerted effective binding capacity in COVID-19. Further, we disclosed the targets, biological functions, and signaling pathways of in COVID-19. The analysis indicated that could help treat COVID-19 through the enhancement of immunologic functions, inhibition of inflammatory reactions and regulation of the cellular microenvironment. In short, the current study used a series of network pharmacology-based and computational analyses to understand and characterize the binding capacity, biological functions, pharmacological targets and therapeutic mechanisms of in COVID-19.

Conclusion

However, the findings were not validated in actual COVID-19 patients, so further investigation is needed to confirm the potential use of for treating COVID-19.

© 2025 Bentham Science Publishers
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2024-06-11
2025-04-01

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/content/journals/cpd/10.2174/0113816128298950240428013723
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An Integrative Network Pharmacology and Bioinformatics Approach for Deciphering the Multi-target Effect of Nyctanthes arbortristis L. against COVID-19
Curr. Pharm. Des. 31, 855 (2025); https://doi.org/10.2174/0113816128298950240428013723
/content/journals/cpd/10.2174/0113816128298950240428013723
/content/journals/cpd/10.2174/0113816128298950240428013723
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  • Article Type:     Research Article
Keyword(s): active compounds; COVID-19; molecular docking simulation; multi-target approach; network pharmacology; Nyctanthes arbortristis

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