Current Pharmaceutical Analysis - Volume 19, Issue 10, 2023

Cervical cancer is one of the most prevalent forms of cancer occurring across the world and it has been observed that about 99.7% of cervical cancer cases occur due to infections with the Human papillomavirus (HPV). Over prolonged durations, cervical cancer can lead to complications such as vaginal bleeding, itching, and in more severe instances, even the fatality of the individual. Cervical cancer is an essential cause Read More

Veterinary drug residues in foods pose risks to consumers and promote antimicrobial resistance. Effective detection methods are needed to monitor and control residues. Recent advancements in analytical techniques for veterinary drug residue detection were reviewed. Key sample preparation methods, including QuEChERS, SPE, ASE, and LLE, were summarized. Instrumental analysis techniques including LC-MS/MS, Read More

Background: N-nitrosodimethylamine (NDMA) are a sort of genotoxic impurities (GTIs) having strong carcinogenic effects and obvious hepatotoxicity. To monitor the NDMA content of metformin hydrochloride sustained-release tablets and enteric capsules in China from 2018 to 2022, a GC-MS/MS method was established and validated.Materials and Methods: The chromatographic column was Agilent VF-WAXms c Read More

Background: A high-performance liquid chromatography (HPLC) method was developed for the determination of Pantoprazole Sodium (PPZ) in the presence of its degradation products. The degradation of PPZ was studied in simulated intestinal fluid (SIF) and simulated gastric fluids (SGF) in various temperature conditions.Aim: This study aimed to establish a simple, sensitive, and rapid RP HPLC method for in-vitro determinati Read More

Background: Recently, a combination prescription with the main ingredients sitagliptin and dapagliflozin as dipeptidyl peptidase-4 andsodium–glucose cotransporter-2 inhibitors, respectively, for the treatment of type 2 diabetes has widely been issued in hospitals. However, the development of double-layered tablets requires simultaneous quantitative dissolution tests that are significantly efficient and cost-effective.Objective: Read More

Background: The liver perfusion method is frequently used in drug pharmacokinetic studies and the various effects of drugs on liver tissue. The aim of this study was to establish and validate an analytical method using high-performance liquid chromatography to determine the simultaneous concentration of losartan and its active metabolite, EXP-3174, in an isolated perfused rat liver study.Method: An HPLC system with isocra Read More