- Home
- A-Z Publications
- Current Proteomics
- Previous Issues
- Volume 8, Issue 3, 2011
Current Proteomics - Volume 8, Issue 3, 2011
Volume 8, Issue 3, 2011
-
-
Editorial [Hot Topic: Platelet Proteomics in Health and Disease (Guest Editor: Wadie F. Bahou)]
More LessThis Special Edition of Current Proteomics is devoted to recent advances in blood platelets that have adapted proteomic or genomic technologies to dissect platelet function. The contents are relevant to the broad audience of biomedical researchers, clinicians, and biotechnology companies interested in novel approaches related to platelet biology. Platelets are fundamentally important in regulating normal hemostasis and pa Read More
-
-
-
Platelet Biomarkers in Tumor Growth
More LessAs the clinical use of biologic response modifiers continues to increase, the old way of estimating effective doses in oncology, i.e. reaching dose-limiting toxicities, is becoming obsolete. Biologic response modifiers and targeted therapies are less toxic and their effective dose is often left shifted on the dose response curve. This is why the majority of pharmaceutical companies have opened new programs seeking biomark Read More
-
-
-
Subcellular Analysis of the Platelet Proteome
Authors: Thomas Premsler, Urs Lewandrowski, Rene Peiman Zahedi and Albert SickmannBlood platelets are key players mainly involved in physiological thrombus formation as well as pathological events, such as atherosclerosis, coronary artery disease, or myocardial infarction. Consequently, numerous studies have focused on gaining insight into the platelet proteome, with biomolecular mass spectrometry providing an efficient technology to cope with this task as it nowadays enables both protein identificati Read More
-
-
-
MicroRNAs as Modulators of the Platelet Proteome
Authors: Patricia Landry and Patrick ProvostMicroRNAs are short 21- to 24-nucleotide (nt) RNA species that act as key regulators of gene expression. Known primarily to modulate mRNA translation through recognition of specific binding sites located in the 3'untranslated region (UTR) of messenger RNA (mRNA) targets, microRNAs may regulate between 30% to 92% of the genes in human, thereby controlling a plethora of biological processes. Although devoid of a n Read More
-
-
-
Platelet Protein Synthesis and Translational Control
Authors: Robert A. Campbell, Neal D. Tolley, Hansjorg Schwertz and Andrew S. WeyrichHuman platelets are released from the cytoplasm of megakaryocytes and average 2-3 μm in diameter. In response to vascular injury, platelets stick together like glue, seal the wounded area, and dispense their contents into the nearby milieu. Taken at face value, these features and functions seem simplistic and unrefined. As one digs deeper, however, it becomes apparent that platelets are intricately wired and creat Read More
-
-
-
Novel Platelet Signalling Pathways Identified via Proteomics
Authors: Patricia B. Maguire, Brian M. Steele and Desmond J. FitzgeraldUnbiased proteomic analyses of cell fractions, interactomes and protein modifications coupled with more targeted approaches are adding to an impressive database of the signalling pathways in platelets. In addition to the well characterised receptors that are known to exist on the platelet surface, platelet proteomic studies continue to expose novel transmembrane proteins including CD148, CLEC-2, Eph kinases and Ephrins Read More
-
-
-
Abundance- and Activity-Based Proteomics in Platelet Biology
Authors: Stephen P. Holly, Xian Chen and Leslie V. PariseHuman platelets are thought to express approximately 2000-3000 proteins, but post-translational modifications, alternatively spliced variants and a rich diversity of vertebrate domain architectures likely make this a conservative estimate. Even though rapidly advancing proteomic techniques have catalyzed the identification of roughly one third of the platelet proteome, a combination of abundance-based and activity-based pr Read More
-
-
-
Integrated Platelet Networks for the Analysis of Different System States
Authors: Marcus Dittrich, Ingvild Birschmann and Thomas DandekarHuman platelets are anucleate cells or rather cellular fragments derived from megakaryocytes. With a life span of just a few days they are nevertheless central components of the haemostatic system and, apart from being the major players in haemostatic processes, they are also involved in the pathophysiology of many cardiovascular diseases and are engaged in inflammatory processes like sepsis. To achieve this, Read More
-
-
-
Proteomics for Transthyretin (TTR) Related Amyloidosis
Authors: Yukio Ando and Mitsuharu UedaOf systemic type of amyloidosis, transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP) is a fatal hereditary amyloidosis with autosomal dominant trait. As of today, reports of 121 different points of mutations or a deletion in the TTR gene have been identified. In addition, senile systemic amyloidosis induced by wild type TTR has been focused in the recent attention. Early diagnosis of FAP is absolutely imper Read More
-
Volumes & issues
-
Volume 21 (2024)
-
Volume 20 (2023)
-
Volume 19 (2022)
-
Volume 18 (2021)
-
Volume 17 (2020)
-
Volume 16 (2019)
-
Volume 15 (2018)
-
Volume 14 (2017)
-
Volume 13 (2016)
-
Volume 12 (2015)
-
Volume 11 (2014)
-
Volume 10 (2013)
-
Volume 9 (2012)
-
Volume 8 (2011)
-
Volume 7 (2010)
-
Volume 6 (2009)
-
Volume 5 (2008)
-
Volume 4 (2007)
-
Volume 3 (2006)
-
Volume 2 (2005)
-
Volume 1 (2004)
Most Read This Month
Article
content/journals/cp
Journal
10
5
false
en
