Skip to content
2000
image of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19-PIMS-grade 3: A Case Report

Abstract

Background

In the face of the rise of COVID-19, the multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19 has been reported, and an increase in MIS-C cases has been observed throughout the world. The majority of these cases were similar to Kawasaki disease concerning clinical presentation.

Case Presentation

Despite similarities, MIS-C cases present clinical and laboratory differentiation, which makes it essential to portray similar cases worldwide to have a better consensus in the future. A 7-year-old male child visited the hospital with the chief complaints of fever associated with chills, rigors, and excessive myalgia for 3 days. He had a history of elevated high C-reactive protein (CRP) of 42.7 mg/L. He was diagnosed with Paediatric inflammatory multisystem syndrome (PIMS)-grade 3. Here, for the first time, we bring an Indian MIS-C case with COVID-19-associated Paediatric inflammatory multisystem syndrome (PIMS)-grade 3.

Conclusion

PIMS-TS infection in paediatrics is associated with a wider range of complications, and the importance of musculoskeletal complications in PIMS-TS has been discussed.

Loading

Article metrics loading...

/content/journals/covid/10.2174/0126667975327652240925113837
2024-10-08
2024-11-22
Loading full text...

Full text loading...

References

  1. Rao G.S.N.K. Gowthami B. Naveen N.R. Samudrala P.K. An updated review on potential therapeutic drug candidates, vaccines and an insight on patents filed for COVID-19. Curr. Res. Pharmacol. Drug Discov. 2021 2 100063 10.1016/j.crphar.2021.100063 34870158
    [Google Scholar]
  2. Nakra N. Blumberg D. Herrera-Guerra A. Lakshminrusimha S. Multi-system inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection: Review of clinical presentation, hypothetical pathogenesis, and proposed management. Children (Basel) 2020 7 7 69 10.3390/children7070069 32630212
    [Google Scholar]
  3. Loke Y.H. Berul C.I. Harahsheh A.S. Multisystem inflammatory syndrome in children: Is there a linkage to Kawasaki disease? Trends Cardiovasc. Med. 2020 30 7 389 396 10.1016/j.tcm.2020.07.004 32702413
    [Google Scholar]
  4. Abrams J.Y. Godfred-Cato S.E. Oster M.E. Chow E.J. Koumans E.H. Bryant B. Leung J.W. Belay E.D. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review. J. Pediatr. 2020 226 45 54.e1 10.1016/j.jpeds.2020.08.003 32768466
    [Google Scholar]
  5. McCrindle B.W. Rowley A.H. Newburger J.W. Burns J.C. Bolger A.F. Gewitz M. Baker A.L. Jackson M.A. Takahashi M. Shah P.B. Kobayashi T. Wu M.H. Saji T.T. Pahl E. Diagnosis, treatment, and long-term management of kawasaki disease: A scientific statement for health professionals from the american heart association. Circulation 2017 135 17 e927 e999 10.1161/CIR.0000000000000484 28356445
    [Google Scholar]
  6. Singh-Grewal D. Lucas R. Macartney K. Cheng A.C. Wood N. Ostring G. Britton P. Crawford N. Burgner D. Update on the COVID‐19‐associated inflammatory syndrome in children and adolescents; paediatric inflammatory multisystem syndrome‐temporally associated with SARS‐CoV‐2. J. Paediatr. Child Health 2020 56 8 1173 1177 10.1111/jpc.15049 32735721
    [Google Scholar]
  7. Whittaker E. Bamford A. Kenny J. Kaforou M. Jones C.E. Shah P. Ramnarayan P. Fraisse A. Miller O. Davies P. Kucera F. Brierley J. McDougall M. Carter M. Tremoulet A. Shimizu C. Herberg J. Burns J.C. Lyall H. Levin M. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA 2020 324 3 259 269 10.1001/jama.2020.10369 32511692
    [Google Scholar]
  8. Opoka-Winiarska V. Grywalska E. Roliński J. PIMS-TS, the new paediatric systemic inflammatory disease related to previous exposure to SARS-CoV-2 Infection—“Rheumatic Fever” of the 21st Century? Int. J. Mol. Sci. 2021 22 9 4488 10.3390/ijms22094488
    [Google Scholar]
  9. Fernández-Sarmiento J. De Souza D. Jabornisky R. Gonzalez G.A. Arias López M.P. Palacio G. Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): a narrative review and the viewpoint of the Latin American Society of Pediatric Intensive Care (SLACIP) Sepsis Committee. BMJ Paediatr. Open 2021 5 1 e000894 10.1136/bmjpo‑2020‑000894 34192188
    [Google Scholar]
  10. Lacina L. Brábek J. Fingerhutová Š. Zeman J. Smetana K. Jr Pediatric Inflammatory Multisystem Syndrome (PIMS) – Potential role for cytokines such Is IL-6. Physiol. Res. 2021 70 2 153 159 10.33549/physiolres.934673 33992044
    [Google Scholar]
  11. Venkataraman A. Kumar N.P. Plasma biomarker profiling of PIMS-TS, COVID-19 and SARS-CoV2 seropositive children - a cross-sectional observational study from southern India. EBioMedicine 2021 66 103317 10.1016/j.ebiom.2021.103317
    [Google Scholar]
/content/journals/covid/10.2174/0126667975327652240925113837
Loading
/content/journals/covid/10.2174/0126667975327652240925113837
Loading

Data & Media loading...


  • Article Type:
    Case Report
Keywords: Coronavirus ; kawasaki disease ; COVID-19 ; PIMS-grade 3 ; MIS-C ; C-reactive protein
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test