Current Organic Synthesis - Volume 3, Issue 4, 2006

There has been significant progress in application of pyranoses and related compounds towards drug discovery and development. This review focuses on strategies for grafting of pharmacophore groups at selected positions on pyranoside and related iminosugar scaffolds. Recent developments in the solid phase synthesis of prospecting combinatorial libraries, syntheses of pyranose based sugar amino acids (SAAs) Read More

This review provides a comprehensive survey of the recent progress in the various preparative methods and the application as catalyst of the thiourea and selenourea, their application in the preparation of heterocycles and their biological significances.

This review will present recent achievements in the use of novel reactants and synthetic procedures for the transformation of substrates into epoxide derivatives. This will include both classical chemical methods using novel catalysts and/or cleaner methodologies, and enzymatic preparations using enzymes or cells. Special attention is paid to the preparation of chiral compounds. A comparison of the advantages a Read More

Indoles are extremely important and basic skeletons in many biologically active natural products with specific structures. The development of effective methods for the construction of the indole moiety is one of the most important aims that synthetic chemistry has pursued. Over the past decade, palladium-catalyzed indole synthesis is arguably one of the most successful and straight forward methods for the construction o Read More

The rhodium(II)-carbenoid mediated transformation of diazocarbonyl compounds is well recognized as a useful process for the facile formation of carbon-carbon and carbon-heteroatom bonds under mild reaction conditions. In this review, the incorporation of rhodium(II)-carbenoid transformations in the synthetic planning and the eventual application of rhodium(II) carbenoid reactions in the synthesis of natural prod Read More