Current Organic Synthesis - Volume 18, Issue 2, 2021

In this review, authors focus mostly on the various synthetic strategies developed so far for 1,2,3- triazole scaffold and its derivatives via different approaches such as metal-free, metal assisted or bimetallic. A brief overview of applications of the very important 1,2,3-triazole scaffold along with pharmacological activity is also discussed. Synthetic strategies are updated until June 2020.

Dess–Martin periodinane (DMP), a commercially available chemical, is frequently utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several merits over other common oxidative agents such as chromiumand DMSO-based oxidants; thus, it is habitually employed in the total synthesis of natural products. In Read More

Pyrazole and its derivatives have gained wide attention in pharmaceutical, agrochemical and biological fields as well as in industry. They exhibit various biological activities such as anti-pyretic, anti-microbial, anti- inflammatory, anti-tumor, anti-viral, anti-histaminic, anti-convulsant, fungicidal, insecticidal, etc. In this review, we summarise the recent advances in the synthesis of pyrazole derivatives using various methodologies Read More

Aims and Objective: Synthesis of novel bis-spirooxindoles was carried out from isatins, two equivalents of malononitrile, and various derivatives of cyclohexanones. Background: A facile one-pot and four-component reaction was investigated for the synthesis of novel bisspirooxindoles from different derivatives of isatins, two equivalents of malononitrile and various derivatives of cyclohexanone in the presence of magnetic C Read More

Aims: In this article, we have developed an eco-friendly one-pot multi-component reaction methodology employed for the green synthesis of functionalized pyrazole derivatives viz cyclo-condensation of aromatic aldehydes, ethyl acetoacetate and phenyl hydrazine and/or hydrazine hydrate in the presence of cetyltrimethylammoniumbromide (CTAB) at 90°C temperature in an aqueous medium. Materials and Method Read More