Current Organic Synthesis - Volume 17, Issue 8, 2020

In recent years, hybrid systems are gaining considerable attention owing to their various biological applications in drug development. Generally, hybrid molecules are constructed from different molecular entities to generate a new functional molecule with improved biological activities. There already exist a large number of naturally occurring hybrid molecules based on both non-steroid and steroid frameworks synthesized by Read More

Rose Oxide is a monoterpene along with cyclic ether used in fragrance to produce rosy notes, in general, there are 4 stereoisomeric structures of the Rose Oxide, which the cis-configured Rose Oxide has a very unique and strong note in perfumery. In this review, several approaches were reported on account of the Rose Oxide applied in perfumery from 1864 to 2019 via quantitative and qualitative approaches.

Polycyclic aromatic hydrocarbons (PAHs) are aromatic compounds with two or more fused benzene rings in their structural configurations. PAHs do not contain heteroatoms and substituents on the ring system. PAHs containing up to four rings are called light PAHs while those that contain more than four rings are considered as heavy PAHs. Heavy PAHs are more stable and more toxic than the light PAHs. Generally, the increase i Read More

Background: Aza-steroids are an important class of compounds because of their numerous biological activities. The hetero steroids have different hydrogen bonding ability and hydrophobicity in comparison to steroids. Materials and Methods: Microwave-induced synthesis of a novel type of hybrid hetero-steroid amine conjugates, following Ugi-four component reactions of steroidal amines with alanine and valine methyl este Read More

Aims: synthesis of pyrano[c-2,3]chromens with Ionic Liquid catalyst with simple method. Background: Synthesis of pyrano[c]coumarins has a special place in the structure due to two bioactive compounds in its structure and attracts a great deal of attention in this research work, it has been attempted to attach chromatically valuable skeletons to them and synthesize the pyrano [c] coumarines, which can potentially have hig Read More

Introduction: We developed a simple, fast and new method for the Fries rearrangement of aryl esters. Materials and Methods: 4-Hydroxy pyridinium triflate functionalized silica is a very efficient, reusable and economically available catalyst for the Fries rearrangement in solvent-free condition and under microwave irradiation. Results and Discussion: Also, a notable selectivity was observed in the presence of 4-hydroxy pyridinium tri Read More

Aim and Objective: According to the literature survey, pyrazole is a unique template that is associated with several biological activities. This article highlighted the research work of many researchers reported in the literature for synthesis and different pharmacological activities of the pyrazole nucleus. In the present work, pyrazol- 3-one 1 was reacted with cyanoacetic acid hydrazide and elemental sulfur to afford the correspon Read More

Aim and objective: Isoxazole is an active core found in many drugs. The aim of this work was to synthesize bis-isoxazoline compounds and to analyze the effect of linker chain length on biological activities. Material and Methods: A simple, convenient, and efficient method for the conversion of bischalcones to new bis(4,5-dihydroisoxazole) derivatives was developed by using hydroxylamine hydrochloride under basic medium. Read More

Thiamine hydrochloride is reported to be a highly competent promoter for the synthesis of bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst. Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of thiamine Read More

A novel process for the preparation of acetone is reported by gas-phase oxidation of propylene in the presence of H2 and O2 with Au supported TS-1 catalyst (Au/TS-1). By elevating the reaction temperature to 280 oC, Au/TS-1 catalyzes 11.6% propylene generating acetone with 70.6% selectivity, and 8.2% acetone in onepass yield. Acetone is originated from propylene oxide isomerization, which is mainly attributed to th Read More