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- Volume 16, Issue 4, 2019
Current Organic Synthesis - Volume 16, Issue 4, 2019
Volume 16, Issue 4, 2019
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s Recent Advances in Transition Metal-Catalyzed Reactions of Oxabenzonorbornadiene
Authors: Rebecca Boutin, Samuel Koh and William TamBackground: Oxabenzonorbornadiene (OBD) is a useful synthetic intermediate capable of undergoing multiple types of transformations due to three key structural features: a free alkene, a bridged oxygen atom, and a highly strained ring system. Most notably, ring-opening reactions of OBD using transition metal catalysts and nucleophiles produce multiple stereocenters in a single step. The resulting dihydronaphthalene fram Read More
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s Small-molecule Bifunctional Fluorescent Probes for the Differential Detection of Multiple Guests
Authors: Pei-Pei Jia, Shu-Ting Jiang and Lin XuDuring the last few years, the preparation of bifunctional fluorescent probes, which exhibit differential response towards multiple analytes, has attracted considerable attention since they are cost-effective and highly desirable for real-time applications. This review focuses on the recent advances in the design principles, recognition mechanisms, and applications of multifunctional fluorescent probes for the differential det Read More
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s The History of the Glycosidase Inhibiting Hyacinthacine C-type Alkaloids: From Discovery to Synthesis.
Authors: Anthony W. Carroll and Stephen G. PyneBackground: The inherent glycosidase inhibitory activity and potentially therapeutic value of the polyhydroxylated pyrrolizidine alkaloids containing a hydroxymethyl substituent at the C-3 position have been well documented. Belonging to this class, the naturally occurring hyacinthacine C-type alkaloids are of general interest among iminosugar researchers. Their selective micromolar α -glycosidase inhibitory ranges (10 – 100 μ Read More
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s New Developments on the Hirao Reactions, Especially from “Green” Point of View
Authors: Réka Henyecz and György KeglevichBackground: The Hirao reaction discovered ca. 35 years ago is an important P–C coupling protocol between dialkyl phosphites and aryl halides in the presence of Pd(PPh3)4 as the catalyst and a base to provide aryl phosphonates. Then, the reaction was extended to other Preagents, such as secondary phosphine oxides and H-phosphinates and to other aryl and hetaryl derivatives to afford also phosphinic esters and tertiary p Read More
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s Transition Metal-Catalyzed Reactions of Alkynyl Halides
Authors: Dina Petko, Samuel Koh and William TamBackground: Transition metal-catalyzed reactions of alkynyl halides are a versatile means of synthesizing a wide array of products. Their use is of particular interest in cycloaddition reactions and in constructing new carbon-carbon and carbon-heteroatom bonds. Transition metal-catalyzed reactions of alkynyl halides have successfully been used in [4+2], [2+2], [2+2+2] and [3+2] cycloaddition reactions. Many carbon-carbo Read More
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s 5-Hydroxymethylfurfural (HMF) in Organic Synthesis: A Review of its Recent Applications Towards Fine Chemicals
Authors: Weigang Fan, Charlie Verrier, Yves Queneau and Florence PopowyczBackground: 5-Hydroxymethylfurfural (5-HMF) is a biomass-derived platform chemical, which can be produced from carbohydrates. In the past decades, 5- HMF has received tremendous attention because of its wide applications in the production of various value-added chemicals, materials and biofuels. The manufacture and the catalytic conversion of 5-HMF to simple industrially-important bulk chemicals have been well revi Read More
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s Organic Synthesis Using Environmentally Benign Acid Catalysis
Authors: Anne Kokel, Christian Schäfer and Béla TörökRecent advances in the application of environmentally benign acid catalysts in organic synthesis are reviewed. The work includes three main parts; (i) description of environmentally benign acid catalysts, (ii) synthesis with heterogeneous and (iii) homogeneous catalysts. The first part provides a brief overview of acid catalysts, both solid acids (metal oxides, zeolites, clays, ion-exchange resins, metal-organic framework based cata Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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