Recent Advances in Ester Synthesis by Multi-Component Reactions (MCRs): A Review

The synthesis of ester-containing heterocyclic compounds via multicomponent reaction is one of the preferable processes in synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range of biological applications in the pharmaceutical field. Therefore, many methods have been developed for the synthesis of these types of derivatives. However, some of them are carried out in the presence of toxic solvents and catalysts, with lower yields, longer reaction times, low selectivities, and byproducts. Thus, the development of new synthetic methods for ester synthesis is required in medicinal chemistry. As we know, multicomponent reactions (MCRs) are a powerful tool for the one-pot ester synthesis, so in this article, we have reviewed the recent developments in ester synthesis. This work covers a selected explanation of methods via multicomponent reactions to explore the methodological development in ester synthesis.