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- ISSN: 1385-2728
- E-ISSN: 1875-5348
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Recent Progress Towards the Total Synthesis and Biological Studies of Calothrixin A and B
- Source: Current Organic Chemistry, Volume 20, Issue 8, Apr 2016, p. 839 - 855
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- 01 Apr 2016
Abstract
Calothrixin A and B are pentacyclic alkaloids isolated from Calothrix Cyanobacteria with unique structural features containing indolo[3,2-j]phenanthridine ring system. These alkaloids possess various biological activities including growth inhibitory effects on a chloroquine-resistant strain of the malarial parasite Plasmodium falciparum and activity against human cancer cells. In this review, various synthetic approaches developed so far for calothrixin A & B and their bioactivities are described.
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