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The present work contains a comprehensive overview of methods published in the period 2005-2011 for the preparation of polyheterocycles containing isoindole-fused ring(s). New synthetic routes are described for the construction of heterocycle-condensed isoindole derivatives with regard to the ring positions and types of these annelated ring systems. On the occasion of the 60th birthday of Prof. Dr. Ferenc Fulop academician.