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Volume 29, Issue 10
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Coumarins are a vital class of compounds recognized for their significant therapeutic potential, both in their natural forms and as synthetic derivatives. Characterized by a benzene ring fused to an α-pyranose ring, coumarins have garnered considerable attention from the scientific community due to their diverse pharmacological activities. This review article highlights the importance of coumarin hybrids, showcasing their enhanced biological properties and reactivity compared to traditional coumarin structures. We explore the pharmacological profiles of various coumarin derivatives, including their anti-cancer, anti-inflammatory, antiviral, antioxidant, antibacterial, and anti-tuberculosis activities, among others. The review examines how the incorporation of different functional groups on the coumarin scaffold can modulate its effectiveness against various diseases, particularly cancer. Furthermore, we discuss promising results from coumarin-based hybrids, such as coumarin-pyridine, coumarin-uracil, and coumarin-quinoline derivatives, demonstrating their efficacy against a range of pathogens. This comprehensive overview serves as a valuable resource for researchers interested in the potential of coumarin derivatives in therapeutic applications.

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2025-05-03

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/content/journals/coc/10.2174/0113852728340045240930075523
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Coumarin Derivatives: Pioneering New Frontiers in Biological Applications
Current Organic Chemistry 29, 794 (2025); https://doi.org/10.2174/0113852728340045240930075523
/content/journals/coc/10.2174/0113852728340045240930075523
/content/journals/coc/10.2174/0113852728340045240930075523
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  • Article Type:     Review Article
Keyword(s): Bioactive compounds; coumarin derivatives; drug development; heterocyclic compounds; innovative synthesis; pharmacological effects; therapeutic potential

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