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Volume 29, Issue 4
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Concerning polycyclic heterocyclic compounds, fused triazolopyrimidines and their substituted analogs have been studied recently from a chemical and biological point of view. Triazolopyrimidines have eight different positional isomers based on their structural arrangement and nitrogen atom positions. The present review concerns synthesizing 1,2,4-triazolo[4,3-c]pyrimidines and 1,2,4-triazolo[1,5-c]pyrimidines fused with a five-membered ring containing one heteroatom. The 1,2,4-triazolo[4,3-c]pyrimidines can be prepared by closing the triazole ring on the 4-hydrazinopyrimidine ring, and the 1,2,4-triazolo[1,5-c]pyrimidines can be prepared by closing the triazole ring on the 4-iminopyrimidine-3-amine ring. The transformation of 1,2,4-triazolo[4,3-c]pyrimidine to the more thermodynamically stable isomer triazolo[1,5-c]pyrimidine derivatives Dimroth rearrangement under different reaction conditions is also discussed. Moreover, the biological activity of both series is presented.

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2024-09-20
2025-01-18

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/content/journals/coc/10.2174/0113852728331504240820050800
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The Chemistry and Biological Effects of Fused 1,2,4-triazolo[4,3-c]pyrimidines and their Isomeric 1,2,4-triazolo[1,5-c]pyrimidines
Current Organic Chemistry 29, 259 (2025); https://doi.org/10.2174/0113852728331504240820050800
/content/journals/coc/10.2174/0113852728331504240820050800
/content/journals/coc/10.2174/0113852728331504240820050800
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  • Article Type:     Review Article
Keyword(s): biological activity; furotriazolopyrimidine; isomers; pyrrolotriazolopyrimidine; thienotriazolopyrimidine; Triazolopyrimidine

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