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Volume 29, Issue 2
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

A practical and novel approach for the regioselective synthesis of 3-arylthioindole derivatives has been accomplished using a combination of indole substrates with toluene sulfonyl hydrazide. This methodology employs NIS as the oxidant and PPh as the reductant to give the desired 3-arylthioindoles in good to excellent yields. This method offers several advantages, including simplicity, operational ease, and broad substrate scope.

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2024-08-19
2024-12-26

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/content/journals/coc/10.2174/0113852728313866240807175713
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Regioselective Thiolation of Indole to Construct 3-Arylthioindoles
Current Organic Chemistry 29, 108 (2025); https://doi.org/10.2174/0113852728313866240807175713
/content/journals/coc/10.2174/0113852728313866240807175713
/content/journals/coc/10.2174/0113852728313866240807175713
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Supplementary material is available on the publisher’s website along with the published article. The characterization results, including spectral data (1H, 13C NMR, and HRMS) of some synthesized compounds, are discussed in the supplementary material.

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  • Article Type:     Research Article
Keyword(s): 3-arylthioindoles; Indole; indole thioether; regioselective; sulfonyl hydrazide; thiolation

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