
Full text loading...
We use cookies to track usage and preferences.I Understand
Effective and “green” synthesis of tetraketone derivatives was elaborated. The last compounds developed prominent bactericide activity against both MIC and MBC S. aureus (ATCC-6538P) bacteria. The novelty of this approach is concluded in the application of Al(OH)3 catalyst for the Knoevenagel-Michael cascade reaction of aromatic aldehydes and 1,3-cyclic diketones in water. The process is chemoselective and affords high yield of tetraketones under benign conditions. The catalyst maintained 80% of initial activity within four cycles. The proposed method can be regarded as an alternative to the existing syntheses of biologically active tetraketones that utilize homogeneous and expensive heterogeneous catalysts.
Article metrics loading...
Full text loading...
References
Data & Media loading...
Supplements