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2000
Volume 28, Issue 20
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

A modified solid-liquid halex reaction was developed in the presence of a robust phase transfer catalyst under microwave conditions. A fast, mild, and practical microwave-assisted synthesis of 2,3-difluoro-5-chloropyridine starting from 2,3,5-trichlorpyridine and spray-dried KF in polar aprotic solvent was developed. The addition of Tetrakis (piperidino) phosphonium chloride as phase transfer catalyst was studied under microwave irritation (450W) and increased the yield and significantly reduced the reaction time in contrast to the conventional heating procedure. The highest reaction rate was observed at 5 wt% phase transfer phosphonium salt catalyst to 2,3,5-trichloropyridine .

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