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Volume 28, Issue 20
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins alcohol dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman-4-one amino ligands () using standard analytical techniques. These ligands, in combination with MnCl‧4HO and CoCl, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes () and other intermediates ( and ) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of the catalytic system, evidenced by the evolution of H gas.

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2024-12-01
2025-01-10

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Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands
Current Organic Chemistry 28, 1593 (2024); https://doi.org/10.2174/0113852728304957240628180342
/content/journals/coc/10.2174/0113852728304957240628180342
/content/journals/coc/10.2174/0113852728304957240628180342
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  • Article Type:     Research Article
Keyword(s): Betti base; catalysis; chroman-4-one; dehydrogenative coupling; heterocycles; pyridine; pyrrole

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