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Volume 29, Issue 9
  • ISSN: 1385-2728
  • E-ISSN: 1875-5348

Abstract

Imidazopyridine holds significance as a crucial fused bicyclic heterocycle within the realm of medicinal chemistry, being acknowledged as a “privileged scaffold” owing to its extensive utility. Numerous methodologies for the synthesis of imidazo[1,2-a]pyridines have been documented, with a considerable focus on strategies aimed at functionalizing these compounds. This study aimed to explore the potential of novel imidazo[1,2-a] pyridine derivatives as agents against drug-resistant , which poses significant challenges in tuberculosis (TB) treatment. The research involved the synthesis of substituted imidazo[1,2-a]pyridine derivatives using site identification and molecular docking techniques. Characterization of the synthesized compounds was carried out using FT-IR, LC-MS, 1H NMR, and 13C NMR analysis. Compounds and showed good anti-TB activity against the HRv strain of , with MIC values of 0.6 μM and 0.9 μM, respectively, which were comparable with the standard drug isoniazid. These findings suggest that imidazo[1,2-a]pyridine derivatives, especially compounds and , have potential as agents against drug-resistant TB, providing valuable insights for ongoing efforts in developing effective TB treatments.

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2024-09-24
2025-05-23

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Synthesis and InhA Inhibition of Imidazo[1,2-a]pyridine Derivatives as Anti-tuberculosis Agents
Current Organic Chemistry 29, 749 (2025); https://doi.org/10.2174/0113852728308259240905051613
/content/journals/coc/10.2174/0113852728308259240905051613
/content/journals/coc/10.2174/0113852728308259240905051613
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  • Article Type:     Research Article
Keyword(s): COVID-19; imidazo[1,2-a]pyridine; InhA inhibition; medicinal chemistry; molecular docking; Mycobacterium tuberculosis

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