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- Volume 11, Issue 1, 2014
Current Neurovascular Research - Volume 11, Issue 1, 2014
Volume 11, Issue 1, 2014
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LINE-1 Methylation is Associated with an Increased Risk of Ischemic Stroke in Men
Authors: Reuy-Tay Lin, Edward Hsi, Hsiu-Fen Lin, Yi-Chu Liao, Yung-Song Wang and Suh-Hang H. JuoThe level of global DNA methylation may be related to the cerebrovascular disease. The methylation level of Long Interspersed Nucleotide Element 1 (LINE-1) can represent the global methylation level. We investigated the association between the methylation levels of LINE-1 and ischemic stroke in Chinese. Two hundred and eighty patients of ischemic stroke and 280 age- and sex-matched controls were enrolled. The mean percen Read More
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Genetic Polymorphism of LDLR (rs688) is Associated with Primary Intracerebral Hemorrhage
Intracranial hemorrhage is the third most common cause of cerebrovascular disease. Some polymorphisms that affect clotting factors increase the risk of thrombosis. However, few reports have analyzed the effect of polymorphisms on the hemostatic state in bleeding disorders. The low-density lipoprotein receptor (LDLR) has been shown to contribute to factor VIII (FVIII) homeostasis, which represents a link between LDLR and h Read More
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Early Timing of Endovascular Treatment for Aneurysmal Subarachnoid Hemorrhage Achieves Improved Outcomes
Authors: Zenghui Qian, Tangming Peng, Aihua Liu, Youxiang Li, Chuhan Jiang, Hongchao Yang, Jing Wu, Huibin Kang and Zhongxue WuTiming of treatment of aneurysmal subarachnoid hemorrhage has been controversial. This retrospective study was designed to access the safety and efficacy among cohorts of different timing of endovascular treatment patients with aneurysmal subarachnoid hemorrhage. A database of patients with aneurysmal subarachnoid hemorrhage was analyzed who were confirmed by CT, and underwent endovascular treatment Read More
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Age-related Vascular Differences among Patients Suffering from Multiple Sclerosis
The aim of our study was to analyze morphological and functional aspects of cerebral veins by means of ecocolor- Doppler in young (i.e., ≤30 years old) and older (i.e., >30 years old) patients suffering from multiple sclerosis. 552 multiple sclerosis patients were evaluated by means of a dedicated Echo-Color-Doppler support (MyLab Vinco echocolor Doppler System, Esaote), in both supine and sitting positions. 458 (83%) s Read More
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Systemic Administration of Fluoro-Gold for the Histological Assessment of Vascular Structure, Integrity and Damage
Authors: John F.Bowyer, Karen M. Tranter, Sumit Sarkar, James Raymick, Joseph P. Hanig and Larry C. SchmuedFluoro-Gold (F-G) has been used extensively as a fluorescent retrograde neuronal-track tracer in the past. We now report that intraperitoneal administration of 10 to 30 mg/ kg of F-G from 30 min to 7 days prior to sacrifice labels vascular endothelial cells of the brain, choroid plexus and meninges and can be used to assess vascular integrity and damage. F-G vascular labeling co-localized with rat endothelial cell antigen ( Read More
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Neurovascular Changes in Acute, sub-Acute and Chronic Mouse Models of Parkinson’s Disease
Although selective neurodegeneration of nigro-striatal dopaminergic neurons is widely accepted as a cause of Parkinson’s disease (PD), the role of vascular components in the brain in PD pathology is not well understood. However, the neurodegeneration seen in PD is known to be associated with neuroinflammatory-like changes that can affect or be associated with brain vascular function. Thus, dysfunction of the capillary end Read More
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Low-dose Tissue Plasminogen Activator is as Effective as Standard Tissue Plasminogen Activator Administration for the Treatment of Acute Ischemic Stroke
Authors: Hui Chen, Guangming Zhu, Nan Liu and Weiwei ZhangWe compared the efficacy of intravenous (IV) combination of low-dose tissue plasminogen activator (tPA) and urokinase (UK) versus either classical IV tPA or UK alone for acute ischemic stroke (AIS) within 4.5 h of symptom onset. One-hundred fifty-three AIS patients were treated with 1 of 3 different IV thrombolytic therapies within a 4.5-h time window. Clinical data included age, gender, type of therapy, NIHSS score, time fro Read More
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Characterization of Lin-ve CD34 and CD117 Cell Population Reveals an Increased Expression in Bone Marrow Derived Stem Cells
Authors: Neeru Jindal, Gillipsie Minhas, Sudesh Prabhakar and Akshay AnandThe purpose of the study was to evaluate the expression of CD45, CD34, Sca-1 and CD117 in mouse bone marrow, Lin-ve and Lin+ve population. Bone marrow cells were isolated from C57/BL6J mouse and mononuclear population was separated from rest of the cell population. With the help of Magnetic associated cell sorter (MACS), Linve and Lin+ve cells were separated from the bone marrow. The expression of CD45, CD34 Read More
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Flow Volumes of Internal Jugular Veins are Significantly Reduced in Patients with Cerebral Venous Sinus Thrombosis
Authors: Ozkan Ozen, Ozkan Unal and Serhat AvcuThe aim of this study was to investigate the flow volumes of the internal jugular veins (IJVs) in patients with cerebral venous sinus thrombosis (CVST) using Doppler ultrasonography (DUS) and to compare the findings with the control group. Forty patients diagnosed with CVST between 2008 and 2010 were included in the study. The patients diagnosed with a thrombosis via MRV and MRI underwent a bilateral examination of th Read More
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Sepsis in the Central Nervous System and Antioxidant Strategies with Nacetylcysteine, Vitamins and Statins
More LessSepsis is the complex syndrome characterized by an imbalance between proinflammatory and antiinflammatory response to infection. The brain may be affected during the sepsis, and acute and long-term brain dysfunctions have been observed in both animal models and septic patients. Oxidative stress and antioxidant systems may prove the basis underling brain dysfunction in sepsis. The antioxidant therapy may be the Read More
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Volumes & issues
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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