Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Nutrition & Food Science
  4. Fast Track Articles
  5. Fast Track Article
image of Beyond Insulin: A Deeper Dive into Pancreatic Disease

Abstract

There are several different categories into which the etiology of pancreatic disease can be subdivided, including inflammation, neoplasia, endocrine dysfunction, and genetic disorders. A comprehensive understanding of the pathogenesis of pancreatitis is necessary for the development of appropriate management methods and therapies, as the disorder has a complicated underlying pathophysiology. Complications such as reduced digestive function, the formation of pseudocysts or abscesses, and ongoing pain are likely as the illness develops. The purpose of this review is to act as a knowledge base. This study aims to examine existing approaches to treating diabetes, including both cutting-edge and tried-and-true therapies. Based on the literature review, the authors discussed how pancreatic failure affected higher animals, explored how the pancreatic exocrine function affects adult and adolescent organism development, and gave an overview of all the conditions that directly affect pancreatic health. There was also a discussion of the link between obesity, lifestyle, nutrition, and pancreatic issues.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cnf/10.2174/0115734013307659240820060042
2024-09-02
2024-10-15

  • From This Site

    /content/journals/cnf/10.2174/0115734013307659240820060042
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Kaneto H. Nakatani Y. Miyatsuka T. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005 54 4 1009 1022 10.2337/diabetes.54.4.1009 15793239
    [Google Scholar]
  2. Takei Y. Loretz C.A. The gastrointestinal tract as an endocrine/neuroendocrine/paracrine organ: organization, chemical messengers and physiological targets. Fish physiology. Academic Press 2010
    [Google Scholar]
  3. Oldfield L.E. Connor A.A. Gallinger S. Molecular events in the natural history of pancreatic cancer. Trends Cancer 2017 3 5 336 346 10.1016/j.trecan.2017.04.005 28718411
    [Google Scholar]
  4. Keller J. Aghdassi A.A. Lerch M.M. Mayerle J.V. Layer P. Tests of pancreatic exocrine function – Clinical significance in pancreatic and non-pancreatic disorders. Best Pract. Res. Clin. Gastroenterol. 2009 23 3 425 439 10.1016/j.bpg.2009.02.013 19505669
    [Google Scholar]
  5. Levitt M.D. Eckfeldt J.H. Diagnosis of acute pancreatitis The Pancreas: Biology, Pathophysiology and Disease. 2nd ed NY Raven Press 1993 613 635
    [Google Scholar]
  6. Vignesvaran K.J. A Study of Etiological Analysis of Acute Pancreatitis and their Outcome in Patients Admitted at Rajiv Gandhi Government General Hospital.
    [Google Scholar]
  7. Goulden M.R. The pain of chronic pancreatitis: a persistent clinical challenge. Br. J. Pain 2013 7 1 8 22 10.1177/2049463713479230 26516493
    [Google Scholar]
  8. Lennon A.M. Wolfgang C.L. Canto M.I. The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia? Cancer Res. 2014 74 13 3381 3389 10.1158/0008‑5472.CAN‑14‑0734 24924775
    [Google Scholar]
  9. Powers A.C. D’Alessio D. Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th ed New York McGraw Hill Publishers 2011 1237 1274
    [Google Scholar]
  10. Dhankhar S. Chauhan S. Mehta D.K. Novel targets for potential therapeutic use in Diabetes mellitus. Diabetol. Metab. Syndr. 2023 15 1 17 10.1186/s13098‑023‑00983‑5 36782201
    [Google Scholar]
  11. Rohilla M Discussing pathologic mechanisms of Diabetic retinopathy & therapeutic potentials of curcumin and β-glucogallin in the management of Diabetic retinopathy. Biomed. Pharmacother. 2023 169 115881 10.1016/j.biopha.2023.115881 37989030
    [Google Scholar]
  12. Sharma P. Rani N. Gangwar A. Singh R. Kaur R. Upadhyaya K. Diabetic neuropathy: a repercussion of vitamin d deficiency. Curr. Diabetes Rev. 2023 19 6 e170822207592 10.2174/1573399819666220817121551 35980059
    [Google Scholar]
  13. Joshi S.K. Shrestha S. Diabetes mellitus: a review of its associations with different environmental factors. Kathmandu Univ. Med. J. 2010 8 29 109 115 21209519
    [Google Scholar]
  14. Rani N. Sharma P. Gangwar A. Dahiya R.S. Verma N. Chemical constituents based approach for the management of diabetes. Curr. Diabetes Rev. 2023 19 5 e220322202506 10.2174/1573399818666220322095033 35319377
    [Google Scholar]
  15. Radha V. Kanthimathi S. Amutha A. Monogenic diabetes reported in south asians: a systematic review. J. Indian Inst. Sci. 2023 103 1 309 334 10.1007/s41745‑023‑00399‑0
    [Google Scholar]
  16. Ying H. Dey P. Yao W. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2016 30 4 355 385 10.1101/gad.275776.115 26883357
    [Google Scholar]
  17. Ilonen J. Lempainen J. Veijola R. The heterogeneous pathogenesis of type 1 diabetes mellitus. Nat. Rev. Endocrinol. 2019 15 11 635 650 10.1038/s41574‑019‑0254‑y 31534209
    [Google Scholar]
  18. Bhattamisra S.K. Siang T.C. Rong C.Y. Type-3c diabetes mellitus, diabetes of exocrine pancreas-an update. Curr. Diabetes Rev. 2019 15 5 382 394 10.2174/1573399815666190115145702 30648511
    [Google Scholar]
  19. Russo P. Rand E.B. Loomes K.M. Diseases of the biliary tree. Pathology of pediatric gastrointestinal and liver disease. Berlin, Heidelberg Springer 2014 10.1007/978‑3‑642‑54053‑0_10
    [Google Scholar]
  20. Doneley B. Avian medicine and surgery in practice: companion and aviary birds. CRC press 2018 10.1201/9781315371047
    [Google Scholar]
  21. Abumrad N.A. Davidson N.O. Role of the gut in lipid homeostasis. Physiol. Rev. 2012 92 3 1061 1085 10.1152/physrev.00019.2011 22811425
    [Google Scholar]
  22. Mukherjee S. The emperor of all maladies: a biography of cancer. Simon and Schuster 2010
    [Google Scholar]
  23. Prado C.L. Pugh-Bernard A.E. Elghazi L. Sosa-Pineda B. Sussel L. Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development. Proc. Natl. Acad. Sci. USA 2004 101 9 2924 2929 10.1073/pnas.0308604100 14970313
    [Google Scholar]
  24. In’t Veld P. Marichal M. Microscopic anatomy of the human islet of Langerhans. The islets of Langerhans. Springer 2010 10.1007/978‑90‑481‑3271‑3_1
    [Google Scholar]
  25. Brereton M.F. Vergari E. Zhang Q. Clark A. Alpha-, delta-and PP-cells: are they the architectural cornerstones of islet structure and co-ordination? J. Histochem. Cytochem. 2015 63 8 575 591 10.1369/0022155415583535 26216135
    [Google Scholar]
  26. Frantz E. Souza-Mello V. Mandarim-de-Lacerda C. Pancreas: anatomy, diseases and health implications. pancreas anatomy. Dis Heal Implicat 2012 45 September 1 52
    [Google Scholar]
  27. Bergman R.N. Orchestration of glucose homeostasis: from a small acorn to the California oak. Diabetes 2007 56 6 1489 1501 10.2337/db07‑9903 17526912
    [Google Scholar]
  28. Guo L. Li Q. Wang W. Apelin inhibits insulin secretion in pancreatic β-cells by activation of PI3-kinase-phosphodiesterase 3B. Endocr. Res. 2009 34 4 142 154 10.3109/07435800903287079 19878074
    [Google Scholar]
  29. Corb Aron R.A. Abid A. Vesa C.M. Recognizing the benefits of pre-/probiotics in metabolic syndrome and type 2 diabetes mellitus considering the influence of Akkermansia muciniphila as a key gut bacterium. Microorganisms 2021 9 3 618 10.3390/microorganisms9030618 33802777
    [Google Scholar]
  30. Momi N. Kaur S. Krishn S.R. Batra S.K. Discovering the route from inflammation to pancreatic cancer. Minerva Gastroenterol. Dietol. 2012 58 4 283 297 23207606
    [Google Scholar]
  31. Lippman S.M. Abate-Shen C. Colbert Maresso K.L. AACR white paper: shaping the future of cancer prevention–a roadmap for advancing science and public health. Cancer Prev. Res. (Phila.) 2018 11 12 735 778 10.1158/1940‑6207.CAPR‑18‑0421 30530635
    [Google Scholar]
  32. Al Neimat K.S. Alserhany A.K. Alanazi M.E. Updates in prevalence, risk factors, management and outcome of treatment of acute pancreatitis. Pharmacophore 2022 13 4 1 7
    [Google Scholar]
  33. Chauhan S. Gupta S. Yasmin S. Saini M. Antihyperglycemic and Antioxidant Potential of Plant Extract of Litchi chinensis and Glycine max. Int. J. Nutr. Pharmacol. Neurol. Dis. 2021 11 3 225 233
    [Google Scholar]
  34. Dhankar S. Mujwar S. Garg N. Artificial Intelligence in The Management of Neurodegenerative Disorders. CNS Neurol. Disord. Drug Targets 2023 37861051
    [Google Scholar]
  35. Zhao Z. Liu W. Pancreatic cancer: a review of risk factors, diagnosis, and treatment. Technol. Cancer Res. Treat. 2020 ••• 19 10.1177/1533033820962117 33357065
    [Google Scholar]
  36. Bien E. Barthlen W. Brecht I.B. Sipos B. Pancreatic Tumors. Rare Tumors in Children and Adolescents. Springer International Publishing 2022 10.1007/978‑3‑030‑92071‑5_28
    [Google Scholar]
  37. Tabish S.A. Is diabetes becoming the biggest epidemic of the twenty-first century? Int. J. Health Sci. (Qassim) 2007 1 2 V VIII 21475425
    [Google Scholar]
  38. Feuchtbaum L. Carter J. Dowray S. Currier R.J. Lorey F. Birth prevalence of disorders detectable through newborn screening by race/ethnicity. Genet. Med. 2012 14 11 937 945 10.1038/gim.2012.76 22766612
    [Google Scholar]
  39. Papp V. Magyari M. Aktas O. Worldwide incidence and prevalence of neuromyelitis optica: a systematic review. Neurology 2021 96 2 59 77 10.1212/WNL.0000000000011153 33310876
    [Google Scholar]
  40. Mederos M.A. Reber H.A. Girgis M.D. Acute Pancreatitis. JAMA 2021 325 4 382 390 10.1001/jama.2020.20317 33496779
    [Google Scholar]
  41. Yadav D. Whitcomb D.C. The role of alcohol and smoking in pancreatitis. Nat. Rev. Gastroenterol. Hepatol. 2010 7 3 131 145 10.1038/nrgastro.2010.6 20125091
    [Google Scholar]
  42. Scherer J. Singh V.P. Pitchumoni C.S. Yadav D. Issues in hypertriglyceridemic pancreatitis: an update. J. Clin. Gastroenterol. 2014 48 3 195 203 10.1097/01.mcg.0000436438.60145.5a 24172179
    [Google Scholar]
  43. Singhi A.D. Pai R.K. Kant J.A. The histopathology of PRSS1 hereditary pancreatitis. Am. J. Surg. Pathol. 2014 38 3 346 353 10.1097/PAS.0000000000000164 24525505
    [Google Scholar]
  44. Banks P.A. Conwell D.L. Toskes P.P. The management of acute and chronic pancreatitis. Gastroenterol. Hepatol. (N. Y.) 2010 6 2 Suppl. 3 1 16 20567557
    [Google Scholar]
  45. Guidelines A.A. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 2013 13 4 Suppl. 2 e1 e15 10.1016/j.pan.2013.07.063 24054878
    [Google Scholar]
  46. Kylänpää L. Rakonczay Z. Jr O’Reilly D.A. The clinical course of acute pancreatitis and the inflammatory mediators that drive it. Int. J. Inflamm. 2012 2012 1 360685 23304633
    [Google Scholar]
  47. Lippi G. Valentino M. Cervellin G. Laboratory diagnosis of acute pancreatitis: in search of the Holy Grail. Crit. Rev. Clin. Lab. Sci. 2012 49 1 18 31 10.3109/10408363.2012.658354 22339380
    [Google Scholar]
  48. James W. Gastrointestinal Pathologies, Dysfunctions, and Disorders. Mosby’s Pathology for Massage Professionals-E-Book. Elsevier 2021
    [Google Scholar]
  49. Hines O.J. Pandol S.J. Management of severe acute pancreatitis. BMJ 2019 367 l6227 10.1136/bmj.l6227 31791953
    [Google Scholar]
  50. Beyer G. Hoffmeister A. Lorenz P. Lynen P. Lerch M.M. Mayerle J. Clinical practice guideline—acute and chronic pancreatitis. Dtsch. Arztebl. Int. 2022 119 29-30 495 501 35945698
    [Google Scholar]
  51. Campbell J. Is pancreatic exocrine insufficiency an under-recognised diagnosis?
    [Google Scholar]
  52. Ponikowski P. Anker S.D. AlHabib K.F. Heart failure: preventing disease and death worldwide. ESC Heart Fail. 2014 1 1 4 25 10.1002/ehf2.12005 28834669
    [Google Scholar]
  53. Langford R.M. Pain management today—what have we learned? Clin. Rheumatol. 2006 25 S1 Suppl. 1 2 8 10.1007/s10067‑006‑0311‑5 16741780
    [Google Scholar]
  54. Tomlin M. Intravenous fluid management. Pharm. J. 2018
    [Google Scholar]
  55. Larsen J.A. Enteral nutrition and tube feeding. Applied veterinary clinical nutrition. Wiley 2023 10.1002/9781119375241.ch20
    [Google Scholar]
  56. Wu G. Ma Y. Wei W. Ondansetron: recommended antiemetics for patients with acute pancreatitis? a population-based study. Front. Pharmacol. 2023 14 1155391 10.3389/fphar.2023.1155391 37234720
    [Google Scholar]
  57. Lammert F. Gurusamy K. Ko C.W. Gallstones. Nat. Rev. Dis. Primers 2016 2 1 16024 10.1038/nrdp.2016.24 27121416
    [Google Scholar]
  58. Meier R. Ockenga J. Pertkiewicz M. ESPEN guidelines on enteral nutrition: pancreas. Clin. Nutr. 2006 25 2 275 284 10.1016/j.clnu.2006.01.019 16678943
    [Google Scholar]
  59. Shyu J.Y. Sainani N.I. Sahni V.A. Necrotizing pancreatitis: diagnosis, imaging, and intervention. Radiographics 2014 34 5 1218 1239 10.1148/rg.345130012 25208277
    [Google Scholar]
  60. Hussain Z. Thu H.E. Amjad M.W. Hussain F. Ahmed T.A. Khan S. Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives. Mater. Sci. Eng. C 2017 77 1316 1326 10.1016/j.msec.2017.03.226 28532009
    [Google Scholar]
  61. Shahrajabian M.H. Sun W. Cheng Q. The power of natural Chinese medicine, ginger and ginseng root in an organic life. Middle East J. Sci. Res. 2019 27 1 64 71
    [Google Scholar]
  62. Mittal P. Dhankhar S. Chauhan S. A review on natural antioxidants for their role in the treatment of Parkinson’s disease. Pharmaceuticals (Basel) 2023 16 7 908 10.3390/ph16070908 37513820
    [Google Scholar]
  63. Merat S. Khalili S. Mostajabi P. Ghorbani A. Ansari R. Malekzadeh R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig. Dis. Sci. 2010 55 5 1385 1390 10.1007/s10620‑009‑0854‑9 19507027
    [Google Scholar]
  64. Sándor Z. Mottaghipisheh J. Veres K. Evidence supports tradition: The in vitro effects of roman chamomile on smooth muscles. Front. Pharmacol. 2018 9 323 10.3389/fphar.2018.00323 29681854
    [Google Scholar]
  65. Lalit K. Navpreet K. Samrat C. Randhir S. Phyto-pharmacological review of Coccinia indica. World J. Pharm. Pharm. Sci. 2014 3 2 1734 1745 [WJPPS
    [Google Scholar]
  66. Pistón M. Machado I. Branco C.S. Infusion, decoction and hydroalcoholic extracts of leaves from artichoke (Cynara cardunculus L. subsp. cardunculus) are effective scavengers of physiologically relevant ROS and RNS. Food Res. Int. 2014 64 150 156 10.1016/j.foodres.2014.05.078 30011634
    [Google Scholar]
  67. Murray M.T. Glycyrrhiza glabra (licorice). Textbook of Natural Medicine. Elsevier 2020
    [Google Scholar]
  68. Gardner TB Adler DG Forsmark CE Sauer BG Taylor JR Whitcomb DC ACG clinical guideline: chronic pancreatitis. 2020
    [Google Scholar]
  69. Etemad B. Whitcomb D.C. Chronic pancreatitis: Diagnosis, classification, and new genetic developments. Gastroenterology 2001 120 3 682 707 10.1053/gast.2001.22586 11179244
    [Google Scholar]
  70. Hardiman O. Al-Chalabi A. Chio A. Amyotrophic lateral sclerosis. Nat. Rev. Dis. Primers 2017 3 1 1 9
    [Google Scholar]
  71. Christodoulou D.K. Tsianos E.V. Role of endoscopic retrograde cholangiopancreatography in pancreatic diseases. World J. Gastroenterol. 2010 16 38 4755 4761 10.3748/wjg.v16.i38.4755 20939103
    [Google Scholar]
  72. Kovacheva-Slavova M.D. Getsov P.G. Vladimirov G.B. Vladimirov B.G. Up-to-date view on the clinical manifestations and complications of chronic pancreatitis. Pancreatitis. IntechOpen 2019 10.5772/intechopen.84738
    [Google Scholar]
  73. Mukherjee P.K. Quality control and evaluation of herbal drugs: Evaluating natural products and traditional medicine. Elsevier 2019
    [Google Scholar]
  74. Chauhan S. Kishore L. Kaur N. Singh R. Potential anti-arthritic agents from Indian medicinal plants. Res Rev 2015 4 3 10 22
    [Google Scholar]
  75. Ma R.H. Ni Z.J. Zhu Y.Y. A recent update on the multifaceted health benefits associated with ginger and its bioactive components. Food Funct. 2021 12 2 519 542 10.1039/D0FO02834G 33367423
    [Google Scholar]
  76. Valussi M. Functional foods with digestion-enhancing properties. 2012
    [Google Scholar]
  77. Matos L.C. Machado J.P. Monteiro F.J. Greten H.J. Understanding traditional Chinese medicine therapeutics: an overview of the basics and clinical applications. Healthcare. MDPI 2021 10.3390/healthcare9030257
    [Google Scholar]
  78. Giugliano D. Ceriello A. Esposito K. The effects of diet on inflammation: emphasis on the metabolic syndrome. J. Am. Coll. Cardiol. 2006 48 4 677 685 10.1016/j.jacc.2006.03.052 16904534
    [Google Scholar]
  79. Boyd J.E. Lanius R.A. McKinnon M.C. Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence. J. Psychiatry Neurosci. 2018 43 1 7 25 10.1503/jpn.170021 29252162
    [Google Scholar]
  80. Kleeff J. Korc M. Apte M. Pancreatic cancer. Nat. Rev. Dis. Primers 2016 2 1 16022 10.1038/nrdp.2016.22 27158978
    [Google Scholar]
  81. McGuigan A. Kelly P. Turkington R.C. Jones C. Coleman H.G. McCain R.S. Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes. World J. Gastroenterol. 2018 24 43 4846 4861 10.3748/wjg.v24.i43.4846 30487695
    [Google Scholar]
  82. Qian D. Zhang T. Zheng P. Comparison of oral antidiabetic drugs as add-on treatments in patients with type 2 diabetes uncontrolled on metformin: a network meta-analysis. Diabetes Ther. 2018 9 5 1945 1958 10.1007/s13300‑018‑0482‑5 30121726
    [Google Scholar]
  83. Rifshana F. Breheny M. Taylor J.E. Ross K. The parental experience of caring for a child with type 1 diabetes. J. Child Fam. Stud. 2017 26 11 3226 3236 10.1007/s10826‑017‑0806‑5
    [Google Scholar]
  84. Dubey K.G. The Indian cuisine. 2010
    [Google Scholar]
  85. Lambrinou E Hansen TB Beulens JWJ Lifestyle factors, self-management and patient empowerment in diabetes care. 2019
    [Google Scholar]
  86. Malpass A. Andrews R. Turner K.M. Patients with Type 2 Diabetes experiences of making multiple lifestyle changes: A qualitative study. Patient Educ. Couns. 2009 74 2 258 263 10.1016/j.pec.2008.08.018 18848413
    [Google Scholar]
  87. Hayward N.J. McDougall G.J. Farag S. Cinnamon shows antidiabetic properties that are species-specific: effects on enzyme activity inhibition and starch digestion. Plant Foods Hum. Nutr. 2019 74 4 544 552 10.1007/s11130‑019‑00760‑8 31372918
    [Google Scholar]
  88. Srinivasa U.M. Naidu M.M. Fenugreek (Trigonella foenum-graecum L.) seed: promising source of nutraceutical. Stud Nat Prod Chem 2021 71 141 184 10.1016/B978‑0‑323‑91095‑8.00014‑3
    [Google Scholar]
  89. Misra A.M. Lalan M.S. Singh V.K. Govil J.N. Role of natural polysaccharides in treatment and control of diabetes. Chemistry and medicinal value. Recent Progr Med Plants 2009 25 347 373
    [Google Scholar]
  90. Ratan Z.A. Haidere M.F. Hong Y.H. Pharmacological potential of ginseng and its major component ginsenosides. J. Ginseng Res. 2021 45 2 199 210 10.1016/j.jgr.2020.02.004 33841000
    [Google Scholar]
  91. Alnajjar M. Kumar Barik S. Bestwick C. Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin. J. Funct. Foods 2020 64 103597 10.1016/j.jff.2019.103597
    [Google Scholar]
  92. Kanmaz H. Gokce Y. Hayaloglu A.A. Volatiles, phenolic compounds and bioactive properties of essential oil and aqueous extract of purple basil (Ocimum basilicum L.) and antidiabetic activity in streptozotocin-induced diabetic Wistar rats. Food Chem. Adv. 2023 3 100429 10.1016/j.focha.2023.100429
    [Google Scholar]
  93. Witt H. Chronic pancreatitis and cystic fibrosis. 2003
    [Google Scholar]
  94. Hegyi P. Wilschanski M. Muallem S. CFTR: a new horizon in the pathomechanism and treatment of pancreatitis. Rev. Physiol. Biochem. Pharmacol. 2016 170 37 66 10.1007/112_2015_5002 26856995
    [Google Scholar]
  95. Lopes-Pacheco M. CFTR modulators: the changing face of cystic fibrosis in the era of precision medicine. Front. Pharmacol. 2020 10 1662 10.3389/fphar.2019.01662 32153386
    [Google Scholar]
  96. Patel L. Assessing self efficacy in caregivers of children with cystic fibrosis.
    [Google Scholar]
  97. Hart P.A. Zen Y. Chari S.T. Recent advances in autoimmune pancreatitis. Gastroenterology 2015 149 1 39 51 10.1053/j.gastro.2015.03.010 25770706
    [Google Scholar]
  98. Abraham M. Khosroshahi A. Diagnostic and treatment workup for IgG4-related disease. Expert Rev. Clin. Immunol. 2017 13 9 867 875 10.1080/1744666X.2017.1354698 28701054
    [Google Scholar]
  99. Okazaki K. Kawa S. Kamisawa T. Shimosegawa T. Tanaka M. Japanese consensus guidelines for management of autoimmune pancreatitis: I. Concept and diagnosis of autoimmune pancreatitis. J. Gastroenterol. 2010 45 3 249 265 10.1007/s00535‑009‑0184‑x 20084528
    [Google Scholar]
  100. Ven Murthy M.R. Ranjekar P. Ramassamy C. Deshpande M. Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: 1. Ashwagandha. Cent. Nerv. Syst. Agents Med. Chem. 2010 10 3 238 246
    [Google Scholar]
  101. Lamba A. Oakes A. Roberts L. Deprele S. Nogaj L. Correlating Indigenous Peruvian Women’s Distance to Cusco and Their Access to Healthcare, and Investigating the Effect of Cat’s Claw Extracts on HeLa Cells. FASEB J. 2019 33 S1 491 493 10.1096/fasebj.2019.33.1_supplement.491.3
    [Google Scholar]
  102. Aggarwal B.B. Yuan W. Li S. Gupta S.C. Curcumin‐free turmeric exhibits anti‐inflammatory and anticancer activities: Identification of novel components of turmeric. Mol. Nutr. Food Res. 2013 57 9 1529 1542 10.1002/mnfr.201200838 23847105
    [Google Scholar]
  103. Shen P. Jiao Y. Miao L. Chen J. Momtazi-Borojeni A.A. Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management. J. Cell. Mol. Med. 2020 24 21 12234 12245 10.1111/jcmm.15803 32969153
    [Google Scholar]
  104. Mehta S. Sharma A.K. Singh R.K. Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update. Phytomed. Plus 2021 1 4 100085 10.1016/j.phyplu.2021.100085
    [Google Scholar]
  105. Hannan M.A. Rahman M.A. Sohag A.A.M. Black cumin (Nigella sativa L.): A comprehensive review on phytochemistry, health benefits, molecular pharmacology, and safety. Nutrients 2021 13 6 1784 10.3390/nu13061784 34073784
    [Google Scholar]
  106. Parasuraman S. Anand David A.V. Arulmoli R. Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacogn. Rev. 2016 10 20 84 89 10.4103/0973‑7847.194044 28082789
    [Google Scholar]
  107. Hafner A. Lovrić J. Lakoš G.P. Pepić I. Nanotherapeutics in the EU: an overview on current state and future directions. Int. J. Nanomedicine 2014 9 1005 1023 24600222
    [Google Scholar]
  108. Sharma S. Kumari N. Garg D. Chauhan S. A Compendium of Bioavailability Enhancement via Niosome Technology. Pharm. Nanotechnol. 2023 11 4 324 338 10.2174/2211738511666230309104323 36892113
    [Google Scholar]
  109. Kenner B. Chari S.T. Kelsen D. Artificial intelligence and early detection of pancreatic cancer: 2020 summative review. Pancreas 2021 50 3 251 279 10.1097/MPA.0000000000001762 33835956
    [Google Scholar]
/content/journals/cnf/10.2174/0115734013307659240820060042
Loading
Beyond Insulin: A Deeper Dive into Pancreatic Disease
Bentham Science Publishers ; https://doi.org/10.2174/0115734013307659240820060042
/content/journals/cnf/10.2174/0115734013307659240820060042
/content/journals/cnf/10.2174/0115734013307659240820060042
Loading

Data & Media loading...

  • Article Type: Review Article
Keywords: treatment ; glandular organ ; pancreas ; herbal ; Pancreatic Neoplasms ; Pancreatic diseases

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test