Introduction of Honeycomb (Nidus Vespae) and Some of Its Most Important Pharmacological Benefits

Background: Nidus Vespae (honeycomb), which is a well-known traditional Chinese medicine, is the honey-comb of Polistes japonicus Saussure, Parapolybia varia Fabricius, or Polistes olivaceus (De Geer), and it is usually harvest in winter and autumn. Methods: Its chemical component is completely complex combining honey, pollen, royal jelly, and propolis and consequently has a significant number of bioactive components such as nitro compounds, flavonoids, and polyphenols. It has shown various pharmacological impacts, such as anti-inflammatory, anti-viral, anti-microbial, and anti-tumor effects. Results: In this review article, all relevant papers from various scholars and researchers were searched in Science Direct, Google Scholar, PubMed, and Scopus. Honeycomb has various activities and numerous pharmacological benefits and health advantages, and it can be considered a valuable source of nutraceuticals, and an effective natural medicine and organic product. Conclusion: In this review, we have decided to discuss the importance of traditional treatment, and the pharmacological properties of Nidus Vespae.