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image of Changes of Unit Cell Parameters in Lactose Saturated by Substances Technologically Processed by Dilution

Abstract

Background

Our research investigates how the structure of a lactose matrix can be altered by the specific drugs used to saturate it. In particular, we examine whether ultra-high dilutions of substances, such as antibodies, can change the crystal structure of lactose.

Methods

We employed methods including X-ray diffractometry, Raman spectroscopy, and granulometric content analysis.

Results

Our findings suggest that once saturated with highly diluted substances, lactose does indeed gain and retain changes in its crystalline structures [particularly cell parameters a, b, c, β]. These changes are most pronounced between intact and saturated lactose samples, and there are also differences observed when using different solutions for saturation.

Conclusion

The results support the idea that ultra-high dilutions can irreversibly change the structure of lactose, potentially due to differences in solution wetting and subsequent recrystallization of the lactose matrix.

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2024-10-07
2025-04-25

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/content/journals/cnano/10.2174/0115734137309344240926051154
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Changes of Unit Cell Parameters in Lactose Saturated by Substances Technologically Processed by Dilution
Bentham Science Publishers ; https://doi.org/10.2174/0115734137309344240926051154
/content/journals/cnano/10.2174/0115734137309344240926051154
/content/journals/cnano/10.2174/0115734137309344240926051154
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  • Article Type:     Research Article
Keywords: TPA ; drug-delivery ; technologically processed antibodies ; Crystallography ; lactose

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