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Volume 17, Issue 1
  • ISSN: 1874-4672
  • E-ISSN: 1874-4702
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Abstract

Background

This study was performed to evaluate the protective effects of chrysin (CH) on metabolic impairment and pancreatic injury caused by sub-chronic chlorpyrifos (CPF) intoxication in male rats.

Methods

Forty male Wistar rats were randomly allocated into five groups (n=8). Intraperitoneal injections of chrysin (12.5, 25 and 50 mg/kg for 45 days) and CPF (10 mg/kg for 45 days) gavage were performed. Present findings indicated that the serum levels of glucose, total cholesterol, and low-density lipoprotein-cholesterol, as well as body weight, were increased in the CPF-exposed group.

Results

It was also found that CPF decreased superoxide dismutase activity as well as increased malondialdehyde and nitric oxide levels in the pancreatic tissue of exposed animals. Histopathological examination also confirmed the toxic effects of CPF on pancreatic tissue as mostly evidenced by infiltration of inflammatory cells and necrosis. CH (50 mg/kg) decreased blood glucose concentration (p < 0.05), TG (p < 0.05), and LDL-C in CPF-exposed animals. CH decreased the pancreas levels of MDA in all treated CPF-exposed groups the non-treated CPF-exposed group (p < 0.05, p < 0.001, p < 0.001, respectively). A significant difference was not seen in the NO and MDA levels and SOD activity between CH-treated (50 mg/kg) animals exposed to CPF and controls. A significant difference was not seen in the NO and MDA levels and SOD activity between CH-treated (50 mg/kg) animals exposed to CPF and controls.

Conclusion

A significant difference was not seen in the NO and MDA levels and SOD activity between CH-treated (50 mg/kg) animals exposed to CPF and controls. In conclusion, CH could prevent initiate and progress of CPF-induced metabolic impairment by modulating oxidative stress in pancreatic tissue as a target organ of organophosphorus pesticides.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2023-04-14
2024-11-23

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References

  1. KacemI. MaouaM. HasniY. KalboussiH. HafsiaM. SouguirS. Evaluation of the risk of metabolic syndrome among shift workers in Tunisia.Eastern Medit. Health J.2019251067785
     [Google Scholar]
  2. LuoK. ZhangR. AimuziR. WangY. NianM. ZhangJ. Exposure to Organophosphate esters and metabolic syndrome in adults.Environ. Int.202014310594110.1016/j.envint.2020.10594132679393
     [Google Scholar]
  3. JayarajR. MeghaP. SreedevP. Review Article. Organochlorine pesticides, their toxic effects on living organisms and their fate in the environment.Interdiscip. Toxicol.201693-49010010.1515/intox‑2016‑001228652852
     [Google Scholar]
  4. WangH. YuS. LiaoJ. QingX. SunD. JiF. SongW. WangL. LiT. A robot platform for highly efficient pollutant purification.Front. Bioeng. Biotechnol.20221090321910.3389/fbioe.2022.90321935782505
     [Google Scholar]
  5. HuangX. CuiH. DuanW. Ecotoxicity of chlorpyrifos to aquatic organisms: A review.Ecotoxicol. Environ. Saf.202020011073110.1016/j.ecoenv.2020.11073132450436
     [Google Scholar]
  6. MuH. LiuC. ZhangQ. MengH. YuS. ZengK. HanJ. JinX. ShiS. YuP. LiT. XuJ. HuaY. Magnetic-Driven Hydrogel Microrobots Selectively Enhance Synthetic Lethality in MTAP-Deleted Osteosarcoma.Front. Bioeng. Biotechnol.20221091145510.3389/fbioe.2022.91145535875497
     [Google Scholar]
  7. GregetR. DadakS. BarbierL. LaugaF. Linossier-PierreS. PernotF. LegendreA. AmbertN. BouteillerJ.M. DorandeuF. BischoffS. BaudryM. FagniL. MoussaouiS. Modeling and simulation of organophosphate-induced neurotoxicity: Prediction and validation by experimental studies.Neurotoxicology20165414015210.1016/j.neuro.2016.04.01327108687
     [Google Scholar]
  8. JiF. LiT. YuS. WuZ. ZhangL. Propulsion gait analysis and fluidic trapping of swinging flexible nanomotors.ACS Nano20211535118512810.1021/acsnano.0c1026933687190
     [Google Scholar]
  9. LiJ. RenF. LiY. LuoJ. PangG. Chlorpyrifos induces metabolic disruption by altering levels of reproductive hormones.J. Agric. Food Chem.20196738105531056210.1021/acs.jafc.9b0360231490076
     [Google Scholar]
  10. SamarghandianS. SaminiF. Azimi-NezhadM. FarkhondehT. Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain.Neurosci Lett.2017659263210.1016/j.neulet.2017.08.065
     [Google Scholar]
  11. Leonel JaveresM.N. HabibR. Judith LaureN. Abbas ShahS.T. ValisM. KucaK. Muhammad NurulainS. Chronic exposure to organophosphates pesticides and risk of metabolic disorder in cohort from pakistan and cameroon.Int. J. Environ. Res. Public Health2021185231010.3390/ijerph1805231033652791
     [Google Scholar]
  12. FarkhondehT. MehrpourO. SadeghiM. AschnerM. AramjooH. RoshanravanB. SamarghandianS. A systematic review on the metabolic effects of chlorpyrifos.Rev. Environ. Health202237113715110.1515/reveh‑2020‑015033962508
     [Google Scholar]
  13. SamarghandianS. Azimi-NezhadM. Mehrad-MajdH. MirhafezS.R. Thymoquinone ameliorates acute renal failure in gentamicin-treated adult male rats.Pharmacology2020963-4112710.1159/000436975
     [Google Scholar]
  14. ZeinaliM. MeybodiN.T. RezaeeS.A. RafatpanahH. HosseinzadehH. Protective effects of chrysin on sub-acute diazinon-induced biochemical, hematological, histopathological alterations, and genotoxicity indices in male BALB/c mice.Drug Chem. Toxicol.201841327028010.1080/01480545.2017.138483429092670
     [Google Scholar]
  15. YeoH. LeeY.H. KohD. LimY. ShinS.Y. Chrysin inhibits NF-κB-dependent CCL5 Transcription by targeting IκB kinase in the atopic dermatitis-like inflammatory microenvironment.Int. J. Mol. Sci.20202119734810.3390/ijms2119734833027922
     [Google Scholar]
  16. Abdel-DaimM.M. DawoodM.A. ElbadawyM. AleyaL. AlkahtaniS.J.A. Spirulina platensis reduced oxidative damage induced by chlorpyrifos toxicity in nile tilapia (oreochromis niloticus).Animals2020103473
     [Google Scholar]
  17. ElsharkawyE.E. YahiaD. Sub-chronic exposure to chlorpyrifos induces hematological, metabolic disorders and oxidative stress in rat: Attenuation by glutathione.Environ Toxicol Pharmacol201335221827
     [Google Scholar]
  18. El-TawilMF Toxicological effects of short-term feeding with chlorpyrifos and chlorpyrifos-methyl insecticides on adult albino rats.Middle East J. Agri. Res.20143220820
     [Google Scholar]
  19. FangB. LiJ.W. ZhangM. RenF.Z. PangG.F. Chronic chlorpyrifos exposure elicits diet-specific effects on metabolism and the gut microbiome in rats.Food Chem. Toxicol.201811114415210.1016/j.fct.2017.11.00129109040
     [Google Scholar]
  20. AckerC.I. NogueiraC.W. Chlorpyrifos acute exposure induces hyperglycemia and hyperlipidemia in rats.Chemosphere201289560260810.1016/j.chemosphere.2012.05.05922832337
     [Google Scholar]
  21. CelikI SuzekHJE Effects of subacute exposure of dichlorvos at sublethal dosages on erythrocyte and tissue antioxidant defense systems and lipid peroxidation in rats.Ecotoxicol Environ Saf20097239058
     [Google Scholar]
  22. AmbaliS.F. AbubakarA.T. KawuM.U. UchenduC. ShittuM. SalamiS.O. Biochemical alterations induced by subchronic chlorpyrifos exposure in Wistar rats: Ameliorative effect of zinc.Biopsy (I)20111996510073
     [Google Scholar]
  23. AmbaliSF OnukakC IdrisSB YaqubLS Vitamin C attenuates short-term hematological and biochemical alterations induced by acute chlorpyrifos exposure in Wistar rats.J. Medi. Medi. Sci.2010110465477
     [Google Scholar]
  24. AlpH. PinarN. DokuyucuR. SahanM. OrucC. KaplanI. SenolS. CeyranA.B. Protective effects of intralipid and caffeic acid phenethyl ester (CAPE) on hepatotoxicity and pancreatic injury caused by dichlorvos in rats.Biochem. Genet.201654680381510.1007/s10528‑016‑9757‑627365043
     [Google Scholar]
  25. GokalpO. BuyukvanlıB. CicekE. OzerM.K. KoyuA. AltuntasI. KoyluH. The effects of diazinon on pancreatic damage and ameliorating role of vitamin E and vitamin C.Pestic. Biochem. Physiol.200581212312810.1016/j.pestbp.2004.11.001
     [Google Scholar]
  26. TuzcuK. AlpH. OzgurT. KarciogluM. DavarciI. EvliyaogluO. KarakusA. HakimogluS. Oral intralipid emulsion use: a novel therapeutic approach to pancreatic β-cell injury caused by malathion toxicity in rats.Drug Chem. Toxicol.201437326126710.3109/01480545.2013.83878024180244
     [Google Scholar]
  27. MansourS.A. MossaA.-THJPB Oxidative damage, biochemical and histopathological alterations in rats exposed to chlorpyrifos and the antioxidant role of zinc.Pesti. Biochem. Physiolo.20109611423
     [Google Scholar]
  28. ZhengT. GaoY. Relationship between blood lipid profiles and pancreatic islet β cell function in Chinese men and women with normal glucose tolerance: A cross-sectional study.BMC Public Health201212634
     [Google Scholar]
  29. ChoiJ.H. YunJ.W. Chrysin induces brown fat-like phenotype and enhances lipid metabolism in 3T3-L1 adipocytes.Nutrition2016329100210
     [Google Scholar]
  30. XiaY. LianS. KhoiP.N. YoonH.J. HanJ.Y. ChayK.O. KimK.K. JungY.D. Chrysin inhibits cell invasion by inhibition of Recepteur d’origine Nantais via suppressing early growth response-1 and NF-κB transcription factor activities in gastric cancer cells.Int. J. Oncol.20154641835184310.3892/ijo.2015.284725625479
     [Google Scholar]
  31. ShoiebS.M. EsmatA. KhalifaA.E. Abdel-NaimA.B. Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats.Food Chem. Toxicol.201811165065910.1016/j.fct.2017.12.01729247772
     [Google Scholar]
/content/journals/cmp/10.2174/1874467216666230220094827
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Protective Effect of Chrysin against Chlorpyrifos-Induced Metabolic Impairment and Pancreatitis in Male Rats
Curr Mol Pharmacol 17, E200223213784 (2024); https://doi.org/10.2174/1874467216666230220094827
/content/journals/cmp/10.2174/1874467216666230220094827
/content/journals/cmp/10.2174/1874467216666230220094827
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  • Article Type:     Research Article
Keyword(s): Chlorpyrifos; Chrysin; Metabolic; Pancreas; Rat; Syndrome

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