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Volume 17, Issue 1
  • ISSN: 1874-4672
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Abstract

Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1’s biological roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-11-22

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Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations
Curr Mol Pharmacol 17, e18761429274883 (2024); https://doi.org/10.2174/0118761429274883231129103220
/content/journals/cmp/10.2174/0118761429274883231129103220
/content/journals/cmp/10.2174/0118761429274883231129103220
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  • Article Type:     Review Article
Keyword(s): ARHGEF2; Cancer; GEF-H1; Guanine nucleotide exchange factor; Rho GTPase; RhoA

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