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- Volume 23, Issue 10, 2023
Current Molecular Medicine - Volume 23, Issue 10, 2023
Volume 23, Issue 10, 2023
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FoxO3 Regulates the Progress and Development of Aging and Aging-Related Diseases
Authors: Zao-Shang Chang, Zhi-Ming He and Jing-Bo XiaAging is an inevitable risk factor for many diseases, including cardiovascular diseases, neurodegenerative diseases, cancer, and diabetes. Investigation into the molecular mechanisms involved in aging and longevity will benefit the treatment of age-dependent diseases and the development of preventative medicine for agingrelated diseases. Current evidence has revealed that FoxO3, encoding the transcription Read More
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Neuroprotective Role of MiRNA-9 in Neurological Diseases: A Mini Review
Authors: Shenglin Wang, Guohui Jiang and Shunxian WangMicroRNAs (miRNAs) are a class of non-coding small RNAs with about 22 nucleotides in eukaryotes. They regulate gene expression at the post-transcriptional level and play a key role in physiological and pathological processes. As one of the most abundant miRNAs in the human brain, miRNA-9 (miR-9) has attracted extensive attention due to its important role in the maintenance of normal function of the nervous syste Read More
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The Role of Vitamins in DNA Methylation as Dietary Supplements or Neutraceuticals: A Systematic Review
Authors: Muhammad M. Fareed, Sana Ullah, Maryam Qasmi and Sergey ShityakovEpigenetic modifications play a vital role in gene regulation associated with different pathologies. Various nutrients in our diet, such as vitamins can modulate these epigenetic mechanism. They also can regulatenderlying pathophysiological factors and processes that directly or indirectly. Most importantly, A, B, C, and D vitamins have recently been shown to be involved in this type of regulation together with vitamins E and K. D Read More
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Cell Adhesion Molecule CD99 in Cancer Immunotherapy
Authors: Feng Yu, Guodong Liu, Hailing Zhang, Xiaoyan Wang, Zhi Wu, Qinggang Xu, Yan Wu and Dongfeng ChenThe CD99 antigen is a transmembrane protein expressed in a broad variety of tissues, particularly in hematopoietic cells, thymus, endothelial cells, etc. It participates in several crucial biological processes, including cell adhesion, migration, death, differentiation, and inflammation. CD99 has shown oncogenic or tumor suppressor roles in different types of cancer. Therefore, it has been used as a biomarker and therapeutic tar Read More
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Targeting ADAM10 in Renal Diseases
Authors: Jie-Na Wang and Xiao-Jing CaoADAM10 is part of the ADAM superfamily containing cell surface proteins with special structures and potential adhesion and protease domains. This paper provides a review of the specific effects of ADAM10 in kidney development as well as its relations with renal diseases. ADAM10 plays an important role in developing tissues and organs and the pathogenesis of multiple diseases. The catalytic mechanism of ADAM10 on kidn Read More
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Bone Marrow Stromal Stem Cell Fate Decision: A Potential Mechanism For Bone Marrow Adipose Increase with Aging-related Osteoporosis
Authors: Li Tian, Lingyun Lu and Yang MengObjective: Osteoporosis is a systemic bone disease that seriously threatens the health and quality of life in middle-aged and older adults. In this review, we describe the relationship between bone marrow adipose tissue and aging osteoporosis and mainly focus on bone marrow mesenchymal stem cell osteogenic-adipose differentiation fate with aging along with the relevant mechanisms responsible for these changes. Methods Read More
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MicroRNAs in the Pathogenesis of Ankylosing Spondylitis and their Clinical Implication
Authors: Lanqing Fu, Guobo Wang, Wei Deng and Yu LuAnkylosing spondylitis (AS) is a chronic and progressive immunoinflammatory disease, which mainly affects the spine and sacroiliac joints and shows a high rate of late disability. Inflammation, bone destruction, and new bone formation are typical pathological changes of AS. AS is dominated by inflammation at the early stage. While bone destruction and heterotopic ossification, the two contradictory manifestations Read More
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Novel Insights into the Important Role of Leptin in Modulating the Pathological Development of Fibrotic-related Diseases
Authors: Huiyuan Kang, Min Lai, Yan´er Yao, Bin Wang, Xin Su and Ye ChengLeptin, as one of the most important cytokines within the circulation, has been confirmed to play a vital role in the hypothalamus of the central nervous system (CNS), which could modulate energy homeostasis by suppressing food intake. Furthermore, leptin could also influence cell metabolism by acting directly on the leptin receptor, which is a relatively small peptide and is mainly produced and released by fat tissu Read More
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Current Progress on Neuroinflammation-mediated Postoperative Cognitive Dysfunction: An Update
Authors: Wenyong Peng, Wei Lu, Xiaofeng Jiang, Chang Xiong, Hua Chai, Libin Cai and Zhijian LanPostoperative cognitive dysfunction (POCD) is a common complication of the central nervous system (CNS) in elderly patients after surgery, showing cognitive changes such as decreased learning and memory ability, impaired concentration, and even personality changes and decreased social behavior ability in severe cases. POCD may appear days or weeks after surgery and persist or even evolve into Alzheimer's diseas Read More
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Protein Phosphorylation Mechanism of Mesenchymal Stem Cells in the Treatment of Sepsis: A Systematic Review and Meta-analysis
Authors: Hongwu Wang, Junlin Luo, Yong Zhong and Lian MaBackground: The severity and mortality of sepsis are related to excessive inflammation and cytokine storm. Nevertheless, little is known about why sepsis has a significant increase in proinflammatory cytokine production, which leads to more severe inflammatory damage. Methods: Mesenchymal stem cells have achieved certain results in the treatment of sepsis, but the specific mechanism remains to be further clari Read More
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Procyanidin B2 Protects TR-iBRB2 Cells Against Hyperglyc emia Stress by Attenuating Oxidative Stress and Inflammasome Activation via Regulation of Redoxosomes/NF-kB Signaling
More LessBackground: Microvascular dysfunction is a hallmark of diabetic retinopathy (DR), which may lead to visual impairment and blindness. Procyanidin B2 (PB2) is a subclass of flavonoids and is widely known due to its anti-oxidant and antiinflammatory effects. However, little is known about the effect of PB2 on hyperglycemia stress-induced retinal microvascular dysfunction. Objective: The purpose of this study was to investigate Read More
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Protein PDK4 Interacts with HMGCS2 to Facilitate High Glucoseinduced Myocardial Injuries
Authors: Wenliang Tan, Huogeng Bao, Ziming Liu, Yuanyuan Liu, Lang Hong and Liang ShaoObjectives: As a distinct type of cardiomyopathy, diabetic cardiomyopathy (DCM) is featured as diastolic or systolic cardiac dysfunction in diabetic patients. In order to broaden the understanding of molecular mechanisms in DCM, we intended to explore the mechanism of the interaction between PDK4 protein and Hmgcs2 in high glucose (HG)-induced myocardial damage. Methods: PDK4 and Hmgcs2 expression in the my Read More
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Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53/Bcl-2/Caspase-3 Signaling Pathway
Authors: Zhenwen Liang, Yu Chen, Rifang Gu, Qi Guo and Xuqiang NieBackground: Asiaticoside (AC) is a triterpenoid saponin found in Centella asiatica (L.) urban extract that has a wide range of pharmacological properties. Our previous study demonstrated that AC could promote angiogenesis in diabetic wounds, but the specific mechanisms remain unknown. Objective: This study aimed to examine the effectiveness and mechanism of AC on human umbilical vein endothelial cells (HU Read More
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Role of Mitophagy in Cigarette Smoke-induced Lung Epithelial Cell Injury In Vitro
Authors: Suwen Wang, Xiaomin Song, Liangyu Wei, Qi Liu, Chenfei Li and Jiong WangBackground: Mitochondria mediate airway inflammatory responses to cigarette smoke (CS). Removal of damaged or defective mitochondrial (mitophagy) may prevent the detrimental impact of CS extract (CSE) on airway and lung epithelial cells. Methods: We studied the effect of a mitophagy activator (Urolithin A, UA) and a mitophagy inhibitor (Liensinine diperchlorate, Ld) on CSE-exposed alveolar (A549) and airwa Read More
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Volumes & issues
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Volume 25 (2025)
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Volume 24 (2024)
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Volume 23 (2023)
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Volume 22 (2022)
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Volume 21 (2021)
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Volume 20 (2020)
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Volume 19 (2019)
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Volume 18 (2018)
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Volume 17 (2017)
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Volume 16 (2016)
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Volume 15 (2015)
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Volume 14 (2014)
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Volume 13 (2013)
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Volume 12 (2012)
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Volume 11 (2011)
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Volume 10 (2010)
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Volume 9 (2009)
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Volume 8 (2008)
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Volume 7 (2007)
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Volume 6 (2006)
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Volume 5 (2005)
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Volume 4 (2004)
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Volume 3 (2003)
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Volume 2 (2002)
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Volume 1 (2001)
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